Research holds promise for herpes vaccine


October 13, 2006
Blog Entry, Health

A study by a Montana State University researcher suggests a new avenue for developing a vaccine against genital herpes and other diseases caused by herpes simplex viruses. In a study published earlier this year in the Virology Journal, MSU virologist William Halford showed that mice vaccinated with a live, genetically-modified herpes simplex virus type 1 (HSV-1) showed no signs of disease 30 days after being exposed to a particularly lethal “wild-type” strain of the virus.A study by a Montana State University researcher suggests a new avenue for developing a vaccine against genital herpes and other diseases caused by herpes simplex viruses.

In a study published earlier this year in the Virology Journal, MSU virologist William Halford showed that mice vaccinated with a live, genetically-modified herpes simplex virus type 1 (HSV-1) showed no signs of disease 30 days after being exposed to a particularly lethal “wild-type” strain of the virus.

In contrast, a second group of mice that received a more conventional vaccine died within six days of being exposed to the same “wild-type” strain.

“We have a clear roadmap for producing an effective live vaccine against genital herpes,” said Halford, who works in MSU’s Department of Veterinary Molecular Biology. “Although my studies were performed with HSV-1, the implications for HSV-2-induced genital herpes are clear. Overall the two viruses are about 99 percent genetically identical.”

An estimated 55 million Americans carry herpes simplex virus type 2 (HSV-2), which causes genital herpes. Infection is life-long. Approximately 5 percent of those with genital herpes – 2 million to 3 million Americans – suffer outbreaks one to four times annually. A vaccine offering life-long protection does not exist.

The key to Halford’s research was understanding how the herpes simplex virus overcame the body’s natural defenses.

A cell infected with the herpes simplex virus sends a warning to neighboring cells. This warning — an interferon response — causes neighboring cells to enter “an anti-viral state” akin to putting on a suit of armor, Halford said.

However, herpes produces a protein, ICP0, that tricks every infected cell into destroying its own armor. Once the cell’s armor is gone, the virus can propagate itself and spread to other cells, which are in turn tricked into lowering their defenses.

In his research, Halford created a vaccine where the genetic instructions that make ICP0 were disrupted. Without instructions on how to do its clever ICP0 trick, the virus can still establish an infection in animals, but the spread of the virus is stopped long before disease can occur.

“In short, we can disarm the virus such that it is absolutely unable to cause disease, but is still remarkably potent as a vaccine,” Halford said.

In a human vaccine, the genetic instructions for ICP0 would actually be removed, creating an “attenuated,” or weakened virus. The rest of the herpes simplex virus’ genetic code would remain intact. Measles, mumps, rubella, polio and yellow fever vaccines are all made from attenuated viruses.

Research in recent decades has focused on subunit vaccines, which are made from one piece of a virus (a protein subunit). Subunit vaccines are safer than attenuated virus vaccines because the subunit cannot replicate or cause disease. However, subunit vaccines have proven ineffective in protecting people against persistent infections like genital herpes and AIDS, Halford said.

“From a theoretical standpoint, subunit vaccines are poor mimics of a natural virus infection,” Halford said. “There’s not enough there for our immune systems to build a protective response against the actual virus.”

Halford, 38, is aware that his approach is controversial.

“This is where I’m young enough that I don’t know how long it can take to swing popular opinion among scientists and clinicians,” he said. “I would hope that in five to six years the scientific community would be willing to seriously consider these proposals.”

Halford hopes to find a commercial partner or secure government funding to advance his research toward a human vaccine.

“I’d like to take this concept from the chalkboard to the clinics,” he said.

From Montana State University

 


259 Responses to Research holds promise for herpes vaccine

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  4. genital herpes February 13, 2013 at 8:59 am #

    A vaccine is over due. We must have something at least.

    http://genitalherpescures.blogspot.in/2012/09/a-vaccine-for-herpes.html

  5. Scott F October 17, 2012 at 5:56 am #

    Developing a vaacccine would be excellent!! Would not have had to go through the hell of realizing that I would have to live with this for life. I had contracted it about 2 years ago. After trying a bunch of ointments, tinctures, etc…I came across this herb called Hypericum mysorense while looking for herbal remedies. I ffinished the course about 6 months ago, and have not had an outbreak since. Definitely worth checking out..

  6. I CARE October 17, 2012 at 4:34 am #

    You are just crazy and really dont care about herpes victims

  7. Please Stop Looking for The Herpes Cure and Just Support it Release June 6, 2012 at 8:27 pm #

    Please Stop Looking for The Herpes Cure and Just Support it Release
    Please Read!!!
    Proof is Provide Wthin
    Many Americas are living with HSV-2 and by signing this petition; you are saying that you will vote against any government official that does not the necessary action to support this petition and turn it in bill. In order to get what we want we must be willing to stand up and fight for it through voting for public officials that support the release of these inventions and voting against the public official that do not support this petition.
    This petition is demanding the immediate release of patents 7,935,235 and 8,067,010 to the public.
    The reason why we are demanding the release of these two inventions is because both inventions where made possible with Government Grants and because it is duty of the United State government to protect the people from threats foreign and domestic and HSV family is a domestic threat
    (Patent 7,935,235) Belief Description of what the invention does
    This invention relates to a method for systemic immune activation which is effective for eliciting both a systemic, non-antigen specific immune response and a strong antigen-specific immune response in a mammal. The method is particularly effective for protecting a mammal from herpes simplex virus. Also disclosed are therapeutic compositions useful in such a method.
    You are a mammal if you didn’t know that.
    Funding information This invention was made with government support under Grant No. 1 R41 AI065015-01 awarded by National Institutes of Health, National Institute of Allergy and Infectious Diseases and Grant No. AI50132 awarded by National Institutes of Health. The government has certain rights in the invention.
    Like to take it if the people demands by voting for it.
    (Patent 8,067,010) ) Belief Description of what the invention does
    The pharmaceutical compositions can be used both prophylactically and therapeutically. The antigens of the invention are recognized by T cells recovered from herpetic lesions. The invention additionally provides methods, including methods for preventing and treating HSV infection, for killing HSV-infected cells, for inhibiting viral replication, for enhancing secretion of antiviral and/or immunomodulatory lymphokines, and for enhancing production of HSV-specific antibody.
    Funding information
    The invention was made with government support under grant numbers AI34616 and AI30731, awarded by the National Institutes of Health. The government has certain rights in the invention.
    Like to take it if the people demands by voting for it.
    The Proof
    Click on the following links
    1. Vaccinating against HSV-1&2 http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=7,935,352.PN.&OS=PN/7,935,352&RS=PN/
    2. The method for CURING HSV-1&2: http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=8067010.PN.&OS=PN/8067010&RS=PN/8067010
    If knowledge is power then you have just received a whole a lot of power. Now exercise your new found strengthen and power and demand the release of the cure from you state Reps and congress. By threating to vote for some that will. So when your children’s or when your children’s children ask you Mom or Dad or Grandma or Grandpapa. What is Genital Herpes you can look them in the eyes and say something you will never have you to worry about ?
    Sign petition below
    http://www.change.org/petitions/50-million-against-hsv-2

  8. ashley June 3, 2012 at 5:46 pm #

    I think all of you are right on. I used to spend a lot to treat my herpes but I recently found a cure that has pretty much stopped my outbreaks. It has been 8 months since my last outbreak so I can say this cure really does work. See more proof at

    https://twitter.com/#!/1minherpescure

  9. Ty May 12, 2012 at 10:53 am #

    Ok, that’s understandable. I’ll do what I can (especially once we know what the options are after this next election). I don’t have any of these diseases but I’m still afraid of the reality this could become in the lives of my children in this new age they’re growing up in and anything I can do to improve this life & place we’ve brought them to I will try…

  10. reanne May 8, 2012 at 9:51 pm #

    I was just trying to get the word out…i couldn’t sign in because i live in canada…no Zip code. If you live in the States you should start it back up again to show the amount of people who are effected by this nasty virus.

  11. reanne May 7, 2012 at 11:03 am #

    I cant really do anything about it, I live in Canada and that petition was for the States. I was trying to get people on board and help out the cause. I even put it on FB and Pinterest. No one was doing.

  12. TY May 6, 2012 at 7:52 am #

    Do You HAVE Herpes 1 &/or 2?

  13. TY May 6, 2012 at 7:49 am #

    “They” can’t stop us all forever.. Somewhere a Genius is concieved every hour of the day and every minute of the night…

  14. TY May 6, 2012 at 7:39 am #

    “The petition you are trying to access has expired, because it failed to meet the signature threshold.”

    PERHAPS YOU SHOULD GET THE AMOUNT OF SIGNATURES YOU NEED ON BOARD (MAYBE IN A MAILING LIST) BEFORE CREATING AND PROMOTING THIS LINK SO THAT YOU COULD ALREADY HAVE WHAT IS REQUIRED PRIOR TO THE FIRST TICK OF THE CLOCK…

  15. TY May 6, 2012 at 7:30 am #

    PETITION EXPIRED! IF YOU GO FOR IT AGAIN I’LL SIGN, PROMOTE AND SUPPORT IT!

  16. Jessi April 12, 2012 at 9:22 pm #

    Agreed. I just recently got hsv and it does affect you mentally. I wish I could reverse time and think twice about my actions.

  17. reanne April 10, 2012 at 10:27 pm #

    HEY EVERYONE PLEASE SIGN THE PETITION TO INCREASE FUNDING FOR HERPES AND HIV RESEARCH!!!!!! PPPLLLEEEEEAAASSSSSEEEEE. AND SPREAD THE WORD TO EVERYONE, ANYONE WE NEED 25000 SIGNATURES, HELP PEOPLE!

    https://wwws.whitehouse.gov/petitions/%21/petition/fund-research-draco-mit-developed-drug-might-safely-and-quickly-kill-all-viruses-including-hiv/gDwVkjzv?utm_source=wh.gov&utm_medium=shorturl&utm_campaign=shorturl

  18. reanne April 10, 2012 at 10:26 pm #

    HEY EVERYONE PLEASE SIGN THE PETITION TO INCREASE FUNDING FOR HERPES AND HIV RESEARCH!!!!!! PPPLLLEEEEEAAASSSSSEEEEE. AND SPREAD THE WORD TO EVERYONE, ANYONE WE NEED 25000 SIGNATURES

    https://wwws.whitehouse.gov/petitions/%21/petition/fund-research-draco-mit-developed-drug-might-safely-and-quickly-kill-all-viruses-including-hiv/gDwVkjzv?utm_source=wh.gov&utm_medium=shorturl&utm_campaign=shorturl

  19. reanne April 10, 2012 at 10:24 pm #

    HEY EVERYONE PLEASE SIGN THE PETITION TO INCREASE FUNDING FOR HERPES AND HIV RESEARCH!!!!!! PPPPLLLEEEEEAAASSSSSEEEEE. AND SPREAD THE WORD!!! WE NEED 25000 SIGNATURES!

    https://wwws.whitehouse.gov/petitions/%21/petition/fund-research-draco-mit-developed-drug-might-safely-and-quickly-kill-all-viruses-including-hiv/gDwVkjzv?utm_source=wh.gov&utm_medium=shorturl&utm_campaign=shorturl

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