Researchers halt, reverse cirrhosis of the liver


December 27, 2007 |

University of California, San Diego researchers have proven in animal studies that fibrosis in the liver can be not only stopped, but reversed. Their discovery, to be published in PLoS Online on December 26, opens the door to treating and curing conditions that lead to excessive tissue scarring such as viral hepatitis, fatty liver disease, cirrhosis, pulmonary fibrosis, scleroderma and burns.

Six years ago, the UC San Diego School of Medicine research team discovered the cause of the excess fibrous tissue growth that leads to liver fibrosis and cirrhosis, and developed a way to block excess scar tissue in mice. At that time, the best hope seemed to be future development of a therapy that would prevent or stop damage in patients suffering from the excessive scarring related to liver or lung disease or severe burns.

In their current study, Martina Buck, Ph.D., assistant professor of medicine at UCSD and the Veterans Affairs San Diego Healthcare System, and Mario Chojkier, M.D., UCSD professor of medicine and liver specialist at the VA, show that by blocking a protein linked to overproduction of scar tissue, they can not only stop the progression of fibrosis in mice, but reverse some of the cell damage that already occurred.

In response to liver injury – for example, cirrhosis caused by alcohol – hepatic stellate cell (HSC) activated by oxidative stress results in large amounts of collagen. Collagen is necessary to heal wounds, but excessive collagen causes scars in tissues. In this paper, the researchers showed that activation of a protein called RSK results in HSC activation and is critical for the progression of liver fibrosis. They theorized that the RSK pathway would be a potential therapeutic target, and developed an RSK inhibitory peptide to block activation of RSK.

The scientists used mice with severe liver fibrosis – similar to the condition in humans with cirrhosis of the liver – that was induced by chronic treatment with a liver toxin known to cause liver damage. The animals, which continued on the liver toxin, were given the RSK-inhibitory peptide. The peptide inhibited RSK activation, which stopped the HSC from proliferating. The peptide also directly activated the caspase or “executioner” protein, which killed the cells producing liver cirrhosis but not the normal cells.

“All control mice had severe liver fibrosis, while all mice that received the RSK-inhibitory peptide had minimal or no liver fibrosis,” said Buck.

Buck explained that the excessive collagen response is blocked by the RSK-inhibitory peptide, but isn’t harmful to the liver. “The cells continue to do their normal, healing work but their excess proliferation is controlled,” Buck said. “Remarkably, the death of HSC may also allow recovery from liver injury and reversal of liver fibrosis.”

The researchers found a similar activation of RSK in activated HSC in humans with severe liver fibrosis but not in control livers, suggesting that this pathway is also relevant in human liver fibrosis. Liver biopsies from patients with liver fibrosis also showed activated RSK.

The study expands on work reported in 2001 in the journal Molecular Cell announcing that a team led by Buck had found that a small piece of an important regulatory protein called C/EBP beta was responsible for fibrous tissue growth, or excessive scar tissue following injury or illness. When normal scarring goes awry, excessive build-up of fibrous tissue can produce disfiguring scars or clog vital internal organs and lead to serious complications. Buck and colleagues developed a mutated protein that stopped this excessive fibrous tissue growth.

“Six years ago, we showed a way to prevent or stop the excessive scarring in animal models,” said Buck. “Our latest finding proves that we can actually reverse the damage.”

Worldwide, almost 800,000 people die from liver cirrhosis each year, and there is currently no treatment for it. Excessive tissue repair in chronic liver disease induced by viral, toxic, immunologic and metabolic disorders all result in excessive scar tissue, and could benefit from therapy developed from the UCSD researchers’ findings.

The research was supported by grants from the National Institutes of Health, the Department of Veterans Affairs and UCSD’s Medical Research Foundation. Buck is the recipient of a Howard Temin Award from the National Cancer Institute.

From http://www.ucsd.edu

68 Responses to Researchers halt, reverse cirrhosis of the liver

  1. ellen bates February 22, 2015 at 2:14 pm #

    I never knew cannabis oil was indeed wonderful and very effective in the treatment of cancer “if not by the government and so called rules to regulate cannabis dad would still have been alive. Thanks to the new policy of legalizing cannabis in my state and have even lost my wife’s kidney cancer, and it was really shocked and surprised when I see a lot of documentary on how the cannabis oil had helped many people to whom His family thought they never could do next undergoing several “Chemo” from the department of my heart, and I have to say a word of appreciation to Dr. Brown Nelson for timely intervention in the lives of my wife suffering from kidney cancer. As I write this testimony in this blog my wife is so strong and healthy even though you have not completed the total dosage “for cannabis and medical consultation opportunity and get in touch with him if you are a cancer patient through their email: (cancermedicationcentre@gmail.com) so you can lit more details

    Treatment Regine:
    I have a pretty big tolerance for marijuana, so I started off with a full grain of rice sized amount of oil instead of a half grain. I gradually increased the dosage every night until I reached a full gram each night. The standard protocol for Rick Simpson Oil is ingesting a total of 60 grams over the course of 2-3 months, but I had 70 grams in total for safe measure. I used the excess as a topical skin care treatment, attacking the visible brown spots on my face and neck.

    3 months later, my cancer was in full remission. Within 4 months, I am cancer-free and officially received a clean bill of health from my doctors. What they don’t know is that the majority of my treatment was using the Rick Simpson Oil. I did use some of the medication they prescribed, but it was in combination with the oil.

    I am elated I want to continue sharing with people who are experiencing what I went through that there is absolutely hope and a cure out there. They just need to be proactive and aggressive with treatment, not wait until it is too late. Get your medication at Phoenix Tears via Email: (cancermedicationcentre@gmail.com)

    In addition to being an effective cancer fighter, there are some nice side effects that come from using the Rick Simpson oil, for instance, I no longer need to take any pain killers. Just one or two drops of the oil will ease the pain and help you sleep like a baby. Best of all, its natural . . . Thanks to all the staff at Amsterdam’s Garden who guided me throughout this journey. You guys are awesome!

  2. Tearscure February 20, 2015 at 9:24 pm #

    , It is was a pleasure that i thank Dr.Rick Simpson for saving my dying husband with his cannabis oil.
    We already lost hope for a better the report came that my husband cannot go for more Chemo anymore. But after so many research online, I gained a lot about the cannabis oil that i bought from Dr.Rick Simpson whose contact I got online on reading a testimony about his past works and glory, The medication was delivered to me within 24 hours by the UPS delivery service after procurement. My husband has completed his treatment, unquenchable joy to all as my husband is cured of his stage 4 lungs cancer within 90 days of treatment. Thanks to all, today i acknowledge the greatness of cannabis oil and to those that wish to purchase the medication contact Dr.Rick Simpson at: ricksimpsonphoenixtearsoil@gmail.com
    Cannabis Oil is the a medication for cancerous disease ricksimpsonphoenixtearsoil@gmail.com

  3. carl February 10, 2015 at 6:31 am #

    I still don’t know the right words to express my Gratitude to Rick Simpson and his wonderful cannabis oil that cured my ailment. In May 2014 i was diagnosed of Melanoma Cancer, it affected my Skin, intestines and eye.. i went for treatment but to no avail, my family advised the rick hemp oil for my ailment, at first i didn’t want to purchase the oil, because i had doubts about it curing my cancer, but after reading about it and doing researches online, i succumbed to the idea, and indeed it was a wonderful one, the cannabis oil successfully cured my cancer!!! after Three months.
    Now i am Hale and Healthy…….. you can contact Rick Simpson on
    ricksimpsonmedicalservices@gmail.com

  4. Phoenix Tearscure February 7, 2015 at 10:25 pm #

    Other Natural Things You Can Do That Could Help

    When people come to me for oil to treat their cancer, the first thing I tell them to do is change their diets. Try to stay away from animal protein as much as possible, since such protein promotes cancer growth. Get a juicing machine and start eating as many raw fruits and vegetables as possible, since plant protein fights the growth of cancer. Stop using sugar and replace its use with natural sweetener’s like raw honey. Get the patient’s PH up as quickly as possible, cancer likes an acidic environment and when you raise the body’s PH it makes it hard for cancer cells to survive. Also start eating the seeds from two apples everyday, this will give you a good daily dose of B17 also known as laetrile. B17 in its own right has a pretty good track record in the treatment of cancer and there are other natural things such as wheat grass, that you may find of benefit as well. Many people who have used the oil to treat their cancers did not change a thing, but the oil still worked its magic and they were healed.

    But if you have a serious condition like cancer I think its a good idea to take other natural things that may help the oil eradicate the cancer and give you a better chance to survive. We are willing and ready to help the patient with all the medical help that are available to see he/she is back to life healthy and free of all this terrible diseases.

    You will need the full treatment of 60 gram to eradicate the cancer from body totally.
    To secure an order for my medication, please go to our email rickcannabisoil@outlook.com for more news at
    email rickcannabisoil@outlook.com
    You have to provide below information for your order.

    Patient’s Name:
    Patient’s Country:
    Patient’s City/State:
    Patient’s Postal Code:
    Patient’s Phone Number:
    Patient’s Delivery Address:

  5. carl November 27, 2014 at 4:39 am #

    I want to thank rick simpson and the entire management of ricksimpsonmedicalservices for their life saving cannabis oil that cured my wife’s thyroid cancer,the doctor told me there was little he could since despite all the chemo and radiation,she wasn’t responding to treatment.so a friend of mine came to our rescue by ordering this cannabis oil from rick simpson medicals services which he said rick has been helping patients fight against cancer of various types so we decided to give it a try,so far my wife is improving very well and presently she can walk around the house all by herself.i felt it’s necessary i let others especially those suffering from this acute disease that once you have a good cannabis oil,it can really give a second chance at life.if you happen to be in dying need of this cannabis oil,you can contact the foundation who supplied us with this email:ricksimpsonmedicalservices@gmail.com

  6. portter mark November 22, 2014 at 7:38 am #

    My Mother was diagnosed with breast cancer and she was at the point of death, with cancer of the Breast in it final stage is now back alive and she is so healthy now. Thanks to Dr rick Simpson cannabis oil that we bought a: ricksimpsoncannabisoils@outlook.com, the Hemp oil was you can contact for your medication at: ricksimpsoncannabisoils@outlook.com

  7. Benedict George November 14, 2014 at 4:48 pm #

    My mother was diagnosed with Stage IV cervical cancer, then i wasted a lot of money for years for treatment,until i saw in the rickcannabisoil@outlook.com
    in the internet that cannabis oil can cure all cancer,i tried to look for a way to get the Rick Simpson Oil and finally a friend of mine helped via email:rickcannabisoil@outlook.com
    told me how to reach him and get the oil,i was able to email him and bought the oil,my mother started taking it on 12th January and glory be to God she was healed in April after her last scan,i would want to thank Rick for the time he spent in getting this oil to save lives his email is : rickcannabisoil@outlook.com
    the oil works for all type of cancer and it is worth it. Mobile: +1 312 835 3384
    (+44) 703 194 2647

  8. lawson bruce October 10, 2014 at 5:52 am #

    I want to use this medium to applause Rick Simpson for curing my Fiance cancer with his
    cannabis oil, my fiance has been suffering from colorectal cancer for
    the pass three years now, but ever since we started using the Rick
    Simpson Cannabis oil for the past 3 months and instruction on how to
    use it, my fiance has fully recovered from her colorectal cancer. The
    Rick Simpson cannabis oil has proven a great success on cure for
    cancer with his cannabis oil and I give him a lot of credits, because
    my fiance cancer was cured within 4 months of successful treatment,
    am getting married to my fiance as her colorectal cancer has been
    totally cured with Rick Simpson cannabis oil which we
    purchase:bef, It has been 4 months now
    of the successful cure of my fiance colorectal cancer and ever since
    my fiance stop treatment and her health has been perfect and
    marvelous. as I am writing this testimony to notify you that my fiance
    has been completely cured of her cancer. any one out there who need
    help, please feel free to get in touch with
    Rick at:rickcannabisoil@gmail.com

Leave a Reply

* Copy This Password *

* Type Or Paste Password Here *