Researchers halt, reverse cirrhosis of the liver


December 27, 2007
Blog Entry, Health, Life & Non-humans

University of California, San Diego researchers have proven in animal studies that fibrosis in the liver can be not only stopped, but reversed. Their discovery, to be published in PLoS Online on December 26, opens the door to treating and curing conditions that lead to excessive tissue scarring such as viral hepatitis, fatty liver disease, cirrhosis, pulmonary fibrosis, scleroderma and burns.

Six years ago, the UC San Diego School of Medicine research team discovered the cause of the excess fibrous tissue growth that leads to liver fibrosis and cirrhosis, and developed a way to block excess scar tissue in mice. At that time, the best hope seemed to be future development of a therapy that would prevent or stop damage in patients suffering from the excessive scarring related to liver or lung disease or severe burns.

In their current study, Martina Buck, Ph.D., assistant professor of medicine at UCSD and the Veterans Affairs San Diego Healthcare System, and Mario Chojkier, M.D., UCSD professor of medicine and liver specialist at the VA, show that by blocking a protein linked to overproduction of scar tissue, they can not only stop the progression of fibrosis in mice, but reverse some of the cell damage that already occurred.

In response to liver injury – for example, cirrhosis caused by alcohol – hepatic stellate cell (HSC) activated by oxidative stress results in large amounts of collagen. Collagen is necessary to heal wounds, but excessive collagen causes scars in tissues. In this paper, the researchers showed that activation of a protein called RSK results in HSC activation and is critical for the progression of liver fibrosis. They theorized that the RSK pathway would be a potential therapeutic target, and developed an RSK inhibitory peptide to block activation of RSK.

The scientists used mice with severe liver fibrosis – similar to the condition in humans with cirrhosis of the liver – that was induced by chronic treatment with a liver toxin known to cause liver damage. The animals, which continued on the liver toxin, were given the RSK-inhibitory peptide. The peptide inhibited RSK activation, which stopped the HSC from proliferating. The peptide also directly activated the caspase or “executioner” protein, which killed the cells producing liver cirrhosis but not the normal cells.

“All control mice had severe liver fibrosis, while all mice that received the RSK-inhibitory peptide had minimal or no liver fibrosis,” said Buck.

Buck explained that the excessive collagen response is blocked by the RSK-inhibitory peptide, but isn’t harmful to the liver. “The cells continue to do their normal, healing work but their excess proliferation is controlled,” Buck said. “Remarkably, the death of HSC may also allow recovery from liver injury and reversal of liver fibrosis.”

The researchers found a similar activation of RSK in activated HSC in humans with severe liver fibrosis but not in control livers, suggesting that this pathway is also relevant in human liver fibrosis. Liver biopsies from patients with liver fibrosis also showed activated RSK.

The study expands on work reported in 2001 in the journal Molecular Cell announcing that a team led by Buck had found that a small piece of an important regulatory protein called C/EBP beta was responsible for fibrous tissue growth, or excessive scar tissue following injury or illness. When normal scarring goes awry, excessive build-up of fibrous tissue can produce disfiguring scars or clog vital internal organs and lead to serious complications. Buck and colleagues developed a mutated protein that stopped this excessive fibrous tissue growth.

“Six years ago, we showed a way to prevent or stop the excessive scarring in animal models,” said Buck. “Our latest finding proves that we can actually reverse the damage.”

Worldwide, almost 800,000 people die from liver cirrhosis each year, and there is currently no treatment for it. Excessive tissue repair in chronic liver disease induced by viral, toxic, immunologic and metabolic disorders all result in excessive scar tissue, and could benefit from therapy developed from the UCSD researchers’ findings.

The research was supported by grants from the National Institutes of Health, the Department of Veterans Affairs and UCSD’s Medical Research Foundation. Buck is the recipient of a Howard Temin Award from the National Cancer Institute.

From http://www.ucsd.edu


58 Responses to Researchers halt, reverse cirrhosis of the liver

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  6. Kim November 5, 2012 at 3:24 pm #

    What are the latest results of testing of RSK inhibitory peptide, for reversal of liver cirrhosis? Has there or will there be any clinical testing using humans as test subjects? Will clinical testing be made available to human volunteers? Please provide me with any information and/or test results. I have Alcoholic Liver Cirrhosis, so my interest is for myself personally…and for anyone else that may be helped by this disclosure.
    Thank you.

  7. J.S. July 10, 2012 at 6:43 pm #

    My son, who is 28, was diagnosed with cirrhosis and we almost lost him. He was in and out of hospitals due to the other problems that arise when your liver doesn’t work. His kidneys started failing and he developed bilateral pfnemonia. He has had two pancreatic attacks that he says feel like the most crucial pain from his chest to his back. He was put on Xifaxan 550 mg twice a day and has taken it for two months twice a day. It is extremely expensive, 30 days cost $1,600. This medication is a miracle worker. He has his color back and his billirubin has gone down to a “2″ when it had been in the “35″ or so. His doctor says he no longer has cirrhosis of the liver and can live a healthy normal life. He has stopped taking the medication and is only on folic acid and Thiamine and Prilosec. I thank God and whoever invented the Xifaxan for it is a miracle pill. 7/10/12

  8. tazer June 15, 2012 at 3:13 am #

    All I hear is this bullshit articles that researches found this and that and done it to animals and there usually dated many years backwards. So where are these miracle cures? Why arnt they being used on people why isnt this on the front page of the news?

  9. Marisol Hernandez May 8, 2012 at 5:46 pm #

    Need A Cure For Cerrhosis For A Woman With 2 Months To Live Please Write Back ASAP!!!!!!! Please

  10. mike May 6, 2012 at 6:54 am #

    hi. it’s mike again. just an update. LISTEN UP!

    I have started, based upon the SUCCESSFUL Results of a 2 Yr. Clinical Trial,
    by my Dr.’s agreement and prescription 8mg Candesartan name brand, ATACAND, only available, no generic in U.S. This is 11 years on the market, safe, shown to REVERSE LIVER FIBROSIS. $90 for 30 days at walmart …with my insurance, only a $30 copay.

    Also, Actigall, 600 mg per day (prescription only)…Known as Urso, UDCA, available $37 at Walmart.

    Look up on google or nih alcoholic fibrosis candesartan …..

    Average liver fibrosis decrease of 30%.

    This is the real deal. Atacand, an Angiotensin 2 receptor blocker, is better than ACE inhibitors. Atacand is used for heart patients also, a blood pressure reducer. Please, please, surround yourself with accurate, current information. Focus on the good news re: cirrhosis, steatohepatitis, fibrosis….fatty liver, nash, nafld.

    Try liver fibrosis at SCIENCE DAILY.com . Also, the World-leading NewsRx.com.

    Tell or print out….and take to) your Dr. about the things you find, especially at nih.gov. Get pushy. My general practice Dr., not my Hepatologist, was the person I approached with the physical printout. He admitted then he had heard “they” were working on this approach.

    We’re in the Best Time to have to deal with liver disease yet. Better than 2 years ago. Much better than last year.

    p.s. Alpha lipoic is now shown to Reverse Liver Fibrosis!!! $7 Walmart. Research this, as always.
    We’re gonna make it after all!!! God Bless. mike

  11. tazer April 25, 2012 at 5:52 pm #

    SO WHY ARNT THEY DOING THIS TO PEOPLE YET I NEED IT I AM SICK I DRINK ALCOHOL AND MY LIVER IS DIEING GIVE ME THIS MEDICINE NOW I DEMAND IT U SELFISH SCIENTISTS TEST ON HUMAN NOT MOUSE!!!!!!!!

  12. don tracey March 3, 2012 at 6:09 pm #

    LloydWright.org is a site explains how Lloyd cured himself from not only cirhosis but liver cancer as well. He got Hep C thru blood transfusions. He has since his recovery taken it upon himself to provide peptides and supplemetns that he learned about with great difficulty in his quest to save his own live through his 9-year-old (now) non profit AlternitiveMedicalSolution.com site. Go to the bottom of the AMS site and clikc on “interviews” to review Lloyd’s set of YouTube interviews which tell the story in a nutshell. Buy his “Triumph Over Hep C” book and it will convince you he is on the level. Best of luck. Varicies is curable as well and discussed in one of the videos. Good Luck.

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  14. mike March 1, 2012 at 10:57 am #

    Thank you for all the Practical, Useful, Accurate info. Really.

    Also, have you considered the following:

    Alpha-lipoic acid 800 – 1200 mg / day total (400 x 2 – 3 / day)
    This helps the endothelial cells, also many other benefits. Needed by damaged livers, it’s a prescription included in liver disease in Germany! OTC here, Walmart.

    Grape Seed Extract –Wonderful Antioxidant $7.00 Walmart 2 caps w/food 3xday

    Choline 2 to 4 tabs/ caps per day.

    Melatonin, up to 20mg at a time, 3 x daily….strong antifibrotic, antioxidant!

    No iron in Multivitamin. Especially men.

    Modified Citrus Pectin, reduces Galectin-3, trials show reversal of liver fibrosis. see NIH.Gov website, key in modified citrus pectin, cirrhosis and galectin-3. You will learn a lot. Empowerment over this illness thru self-education; it works.

    If platelets above 100,000, research gingko biloba, korean panax ginseng,
    ginger. All 3 are shown to reverse liver fibrosis. It’s at NIH.gov also. By the way, NIH is the NATIONAL INSTITUTES OF HEALTH. They work with FDA and pharmaceutical co’s. to present clinical trial results, etc.

    Magnesium (over 70% of U.S. is deficient) $4.00 Walmart. 600 mg per day. Helps Cure constipation. Rids body of toxic rotting poop. In Cirrhosis, an inflammatory and vascular disease, it’s important to be careful not to strain when trying to poop. I had colonoscopy and butt surgery same day as variceal endoscopy. Hopefully, since i was out (general anesthesia), they did my throat first.:))
    I was almost dead for a week 3 years ago after the gastric/variceal hemorrhage. Now, according to formulas, I should have about 17 years, EVEN though I started as End Stage….Stage 4 Cirrhosis. Hope and Prayers, Love and Information, Genuine Care for You ABOUNDS. There is Information and CCCCCheap, over the counter supplementation along with generic medicine for virtually ALL of Us. Dr. Arshad is in Bowling Green, KY. Gastroenterologist. Limit radiation, xrays, dye contrast . check 2x yr. for liver cancer…find hospital with charity if uninsured, low income. If platelets below 60,000 prefer gym machines AND Elastic Bands to free weights. Remember, no straining. Caution lifting 1 yr. olds, like my nephew at 25 lbs.

    Focus on the solution. Set some goals. We’re here for a long time. Do what you can the second you feel well enough to do so. There can be bumps in the road. Get ready. Receive new diagnosis, information…then move forward.

    Be thankful for the energy and health you have and use it. Help someone less fortunate. Because you can. and it will make you both feel uplifted.

    love to all, mike

  15. George February 8, 2012 at 12:31 pm #

    hi mike -
    i greatly enjoyed your narrative above -
    i too am a big fan of joyce meyer & andrew wommack too – both are highly anointed teachers!
    would love to establish contact w/you and could use an encouraging pen pal! i have ald too – stage 2 they think but biopsy soon to confirm. are you by chance a member of any of the liver disease support websites?
    best wishes -
    george

  16. George February 8, 2012 at 12:28 pm #

    hi mike -
    greatly enjoyed your narrative above -
    i’m a big fan of joyce meyer & andrew wommack too – both are highly anointed teachers!
    would love to establish contact w/you and could use an encouraging pen pal! i have ald too – stage 2 they think but biopsy soon to confirm. are you a member of any of the liver disease support websites?
    george

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  19. vuyiseka January 11, 2012 at 9:32 pm #

    Hi Annie. Have u found out abt the RSK as I need it for my mother. She is suffering. Pls revert to me

  20. tebbs December 29, 2011 at 1:32 pm #

    Hi Mike. My husband has been diagnosed with stage 4 liver disease with cirrhosis. He has had bleeding varicies also. I am glad to hear you are improving. Have your actual liver scans or MRI’s shown improvement in the appearance of your liver? My husband was told he will need a transplant in five years. He liver disease is non alcoholic.

  21. Lil December 4, 2011 at 10:08 am #

    If your father has cirrhosis due to hepatitis c from a transfusion I’d look into thymic protein A by Dr. Beardsley. Many claim to be helped from it. God Bless.

  22. Toma November 26, 2011 at 4:36 pm #

    My sentiments exactly

  23. Toma November 26, 2011 at 4:34 pm #

    Reading these types of things is always a frustration. I remember as a child seeingsee cool pictures of “concept cars”, and then looking on the street see the typical GM box car. From presentation of concept car to reality either never happens or happens 20 years later. Our system of going from study top reality in the drug domain is so damn slow. When my mom died of cancer in 1977 I remember somone saying, “boy if she only had lived a few years more they could have cured it. B______t, Where are all the wonder drug? The only drug news I hear about are the ones that kill us…Vioxx et al.
    Here’s my prediction: the aformentioned substance for reversing Cirrhosis will be available in 20 years.

  24. mike November 21, 2011 at 8:34 am #

    hi. sorry to hear about your situation. here’s my story. 2 yrs. ago had variceal bleedout, 1.5 quarts of blood vomited. diagnosed that nite with cirrhosis. have read like it’s my job…and if i don’t do it, all 7 of my dr.’s are less than brilliant, including 5 at Vanderbilt.

    guess what… my meld score started at 7, then 10 last yr. now 10 to 11 after 2.5 years. i take: curcumin (the bcm-95 version..created by baylor college of medicine) 2 at a time, 4 times a day..to stay in blood..amazing. u should read about nanocurc, the vaccine johns hopkins is testing in cancer, alzheimer’s, etc. with curcumin!!!

    also, good multivitamin and mineral, like centrum for men.
    i LIVE on Milk Thistle…Walmart $8.00!!! 2 softgels, 4 times a day.
    also Wmart Zinc 1 / day.
    Selenium 200 mcg 1 to 2 / day…Vanderbilt did big study..it works.
    Lecithin concentrate 400mg Walmart…3 at a time, 3 times / day.
    Melatonin is also an Antifibrotic and helps to sleep as well. 5mg (2 to 3 before sleep) once or twice a day.

    Repeat After me. 2 words. Antifibrotic. Antioxidant. Also, ask Dr. about Iron. For me, NO Iron. None. No red meat. Very little meat, except tuna or salmon (wild caught, frozen walmart..not expensive)..

    Beans, legumes, for protein and nuts..preferably only walnuts or almonds.
    also, milk, easy protein to digest.

    no High Fructose Corn Syrup. Goodbye, Coke! Read All Labels.

    Limit Total Sodium to 2000 or less, maybe 1500 mg PER DAY.. hard to do.

    bottled water, no fizz, no sweetner… just plain bottled water with lemon wedges.. livers love lemons… squeeze the juice fresh from a wedge into water, then drop wedge into water.

    Cheap medicine, needed: probably Nadolol for high blood pressure..generic, very, very cheap.

    also, spironolactone for diuretic to prevent ascites. ascites is a big challenge, as it leads to a DECOMPENSATED State of Cirrhosis.
    Vanderbilt just told me i am in better shape now than when it all Started!
    I have stopped 5 prescription medicines…they all have little side effects and interactions it seems.

    I also watch Joyce Meyer for spiritual enlightenment and Andrew Wommack, both are online with years of episodes. uplifting!

    ALL CAPS ON PURPOSE>>>>>Google Liver Fibrosis…look at all the news.
    There Are Many Multibillion $ Co’s. tripping over themselves to get the medicine out there …the ANTIFIBROTIC that will also reverse heart damage, kidney damage, lung fibrosis… it’s all the same concept…Thank goodness for Greed, as the Diabesity epidemic diabetic type 2, due to obesity (30% of weight is bodyfat). Cure for Non Alcoholic Fatty Liver Disease urgently needed. Also, Huge, Giant Great News for Hepatitis C cure in news over last 2 months, especially November, 2011.

    Go to PubMed.gov This is the clearinghouse for Medical Experimental and Clinical Trials in the U.S. and Abroad…the entire world of information at your fingertips.

    Find out your platelet count. Mine is around 60,000. Normal is 150,000 to 400,000. I was below that when i was diagnosed.

    I am Living With this Disease. Eager, looking forward to prescription type cure within 2 to 3 years….if not sooner!!!!! Really!!! Big $ for Huge Market.

    May God Bless and Keep You Near to His Heart. You will make it through this.

    just like me. mike

  25. annie November 13, 2011 at 5:19 am #

    Need exact info if any drug really exists now for reverse cirrhosis of the liver. I am at the advanced stage of this illness.
    If anyone knows this RSK thing works well to cure this desease, please email me to djuniw@bdg.centrin.net.id
    Appreciate it.

  26. svtcfl April 2, 2011 at 9:30 am #

    Hi, I had 2 liver function test with normal results. I drank heavy for 7 years and worry about damage. Are the test reliable? What can I do to heal up? I quit drinking almost 2 months ago. Many thanks!

  27. Anonymous November 13, 2010 at 8:38 pm #

    How many decades away is this suppose to be? Sounds good but will it go any farther then a story or or science lab?

  28. Amado Roorda November 9, 2010 at 9:58 am #

    Wow

  29. anonymous October 31, 2010 at 12:04 pm #

    I am in dire search for a cure for my son with Cystic Fibrosis, he has cirrhosis of the liver from his CF. He is my life and only 17. Any information would be appreciative.

  30. Wayne October 25, 2010 at 4:25 pm #

    My father died today of liver Cirrhosis 11 months after being diagnosed with it. What an ugly, cruel death to watch. Rest in peace father, and god bless.

    Good luck top the rest of you guys out there.

  31. Shelly October 20, 2010 at 6:44 pm #

    My name is Shelly Coss. My husband has been diagnosed with cirrhosis of the liver. We lost our insurance when he lost his job due to no work. If anybody is having any success with herbs or alternative medicine please let me know. my e-mail is rscoss@yahoo.com Will be waiting for a reply. Thank you

  32. Shelly October 20, 2010 at 6:40 pm #

    What stage was you diagnosed. My husband was diagnosed stage four. The medical field offers me no hope. We lost our insurance along with his job. We are now trying alternative medicine. He seems to feel better and he definately looks better.

  33. 3sfe October 5, 2010 at 5:22 pm #

    They allways claim to be close to a cure for some
    Disease but notice it never happens? They usaully say things like five or ten years then twenty years go by never to be heard of again these stories pop up then dwindles away truth is they give false hope making it apear that science is advancing when the truth is we are still living in medicine the way we did 30 years ago. Still no cures for anything. Yet computer technology doubles every two years

  34. herbalist September 20, 2010 at 11:45 am #

    this post may be good for you
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  35. Annie July 10, 2010 at 11:38 am #

    how will i know that cirrohsis is reversing? Is ascite curable in cirroshis?

  36. liv52 June 15, 2010 at 4:23 am #

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  37. Anonymous February 20, 2010 at 4:11 am #

    I would like to know if any supplement company is manufacturing this RSK inhibitory peptide. They do not mention a name or possible chemical component to this peptide so it will be hard to track down.

    In the mean time quite drinking, quit eating processed foods, start to eat whole foods and buy a juicer.

    The following protocol may slow down the progression of the disease for some individuals.

    1/2 lemon and water 1st thing in the morning
    Branch Chain amino acids 1 heaping tsp per day – empty stomach
    Milk Thistle – 800 to 1200 mg per day ( capsules)empty stomach
    Same – 400 mg 3 to 4 times per day empty stomach
    Vitamin C 3000mg per day
    B12 1000mcg to 5000mcg per day sublingual – empty stomach
    Folic Acid 400 – 800mg – with food
    B6 100+ mg per day. – with food
    ***Do not take niacin ( B3) take all other B vitamins individually
    Fiber – like psyllium powder
    Lots of water

    Eat well as malnutrition is a big problem with this disease. Protein is very important so if you are a vegan or veggie please break it by at least incorporating the Branch Chain Amino Acids.

    Good luck

  38. Anonymous February 8, 2010 at 2:19 am #

    so, whens this supose to happen?they have been making lots of claims that there close to curing lots of diseses like diabetes and aids,but i dont see it happening there allways making these kind of claims.

  39. Anonymous February 8, 2010 at 2:19 am #

    so, whens this supose to happen?they have been making lots of claims that there close to curing lots of diseses like diabetes and aids,but i dont see it happening there allways making these kind of claims.

  40. Anonymous February 2, 2010 at 12:27 am #

    I’m so glad to see someone else sees what I see. People have no idea that they are being mislead; all in the name of money. Yes, there are cures! I’ll give you one example of the bullshit in this country… Kidney Stones. It has been known for at least 20 years that a natural gut bacteria (pro-biotic) called ‘Oxalobacter Formigenes’ prevents clacium oxalate stones when present in the human gut. It is normally present, however, certain antibiotics can wipe it out leaving you vulnerable to these stones. Put it up on the “more studies needed shelf”…….

  41. Anonymous January 20, 2010 at 4:15 pm #

    I am currently reversing my cirrhosis, my numbers all came down drastically these past few months, and I am not “taking” any cure. My doc put me on an ALL ORGANIC diet, no alcohol, no preservatives, etc. That’s it. (well, exercise, but they say that for EVERYTHING).

    The liver is regenerative, as everyone tells me, and mine seems to be. If you are looking at liver damage or disease, I highly recommend the all organic lifestyle. I’ve been on it since the summer, and it’s only 6 months later that my numbers are all within normal limits.

    Good luck to you.

  42. Anonymous July 11, 2009 at 11:20 pm #

    We have a plant juice which is very active agaginst diabetic. But when the plant part is kept for few days, few microorganism grow inside plant part. The contaminated plant juice also reduces Blood glucose level of mouse but seriousely affected the liver and within 12 hours the treated mice died. On the other hand the fresh plant juice treated mice survive.
    This juice prevent alloxan action to induce diabetic on mice. This is a great finding about this plant juice.
    We are now searching the cause of such toxicity. We are also trying to find out whether this juice could recover diabetic induced mice to normal. Since it reduces blood sugar level and lipid profile of the alloxan induced diabetic mice and also prevent alloxan action in the process of inducing diabetic, we are expecting a good antidiabetic drug from it. This drug will not only control diabetic but may cure diabetic diseases.

    Dr.Md. Anwar Ul Islam
    Professor
    Department of Pharmacy
    University of Rajshahi
    Rajshahi-6205
    Bangladesh.
    Email: profanwarulislam@yahoo.com

  43. Anonymous January 5, 2010 at 11:10 am #

    the cure will sit on a shelf because like stated before no money in a cure just the toxic treatments how many times before have you heard of these posible cures that are just forgoten about its allways the same thing ten years there will be a cure but we have yet to even cure one person of any illness a true cure

  44. Anonymous May 28, 2009 at 8:36 pm #

    You have given me some very needed hope>GOD BLESS YOU AND YOURS!!

  45. Anonymous May 2, 2009 at 7:51 am #

    can you cite the sources for this info. Journal articles would be prefered

  46. Anonymous April 15, 2009 at 8:21 am #

    Did you try Oxymatrine?

  47. Anonymous April 5, 2009 at 3:11 am #

    Japan has reversed Cirrhosis and so has England but my guess is we won’t see these cures as I believe it is all about the money in this greedy country!

  48. Anonymous April 1, 2009 at 12:12 am #

    It will probably be awhile before this or any drug treatment for cirrhosis becomes available. In the meantime, try to eat well. Silymarin (milk thistle extract) can also help to protect the liver from further damage, and BCAA’s (branched chain amino acids) and whey based supplements as used by bodybuilders can help prevent muscle wasting. Red meats,
    salt, and excess vitamin A should be avoided.

    Sulfasalazine, a drug commonly used for Crohn’s disease, has been tried with some success in reversing cirrhosis. Stronger analogues have also been synthesized and are under investigation. Such experimental drug regimes always require close medical supervision and monitoring and may also carry some grave risks including death, but for those with advanced cirrhosis and little or no chance of a transplant, they may be an option. Small interfering RNA (si-RNA) is also under study. The research is very promising as mechanisms for potential reversal of the disease are now being discovered, but from research to market typically takes many years.

    For anyone desperately trying to save a loved one please be careful and don’t get scammed by false claims for miracle cures. There are at this time no drugs or herbal remedies known to cure cirrhosis. Although some may be helpful, many will do more harm than good. I would know. I’ve worked for a few international pharmaceutical companies. I’m an organic chemistry, biochem, herb and nutrition nut and I’ve spent
    years looking for a cure. The love of my life is still dying of cirrhosis and I would do anything to help, but all I can do is pray.

    Of course we may yet discover some other natural-source protein(s) that have the same effects in humans as the mutated protein successfully used in mice to reverse cirrhosis. Who knows? God is great. Keep the Faith.

    Namaste.

  49. Anonymous December 26, 2008 at 11:05 am #

    please publish more on reversal of liver cirrhosis thank you robin

  50. Anonymous September 29, 2008 at 8:44 am #

    My father has cirrhosis due to blood transfusion. He is very bad right now, and is currently in hospital with renal failure, he is recovering but the ascetis is not decreasing ….
    Need to know if this solution works and is available…..

    if yes where can one get it and how soon???

    please revert.

    Gajendra
    Bombay India

  51. Anonymous August 22, 2008 at 9:37 pm #

    Hi did you get any response as to when such a drug would become available for humans?

    Thanks

  52. Anonymous May 4, 2008 at 7:09 pm #

    Hi,

    My name is Ezani from Malaysia. My father has cirrhosis. Kindly help me please if you have the solution. contact me at ezaniafzan@gmail.com. Thank you

  53. Anonymous April 6, 2008 at 8:18 am #

    If there is a type of medication that can be taken to reverse cirhosis of the liver, can people who have developed Diabetes II from the disease be able to reverse it too? I would like to know who I need to refer these kind of questions to.? So if anyone knows would you please let me know? Also, can I ask my transplant center/drs. what they think? Best of luck to everyone. Recovering from cirrhosis without surgery would be great! How soon could this become a alternative. Please email me at shannonc36@yahoo.com

    Best regards.

  54. Anonymous March 29, 2008 at 10:25 am #

    hi my name is Rishi Bhanot and my father is having this cirrhosis of liver. I am very interested in any such medication if atall available which can help in reversing the damages already done or atleast which can improve his condition to lead reasonably good quality life. Currently he is facing the complications of ascites and encephalopathy.
    I would really appreciate if i can get any help.
    Thanks alot in advance!
    Can contact me on rishibhanot@yahoo.com or
    +91 9910036002

  55. Anonymous March 25, 2008 at 5:08 am #

    I’m very interested in the possibility of reversing cirrhosis. I wonder how many other trials will there have to be before the treatment will be available to the public? Because, currently the only treatment available for “cirrhosis” is liver transplantation and not everyone may either be willing to have it or unable to, due to other health conditions. And unfortunately there isn’t any sort of liver dialysis available yet, although I heard that a product called Sepet is already in clinical trials. But even so – this would be a tremendous boost to the treatment of liver diseases.

  56. Anonymous February 18, 2008 at 4:38 pm #

    Hi my name is john i have cirrhosis of the liver to did you get help for your mother? iam looking for that same help please get back to me

  57. Anonymous January 29, 2008 at 1:29 pm #

    Hello! My name is Adrian Prisacariu and i am a young doctor from Romania. My mother is suferring from Liver Cirrhosis and i discover on the internet that in your university a group of researchers have identified a sintetic protein that can stop the evolution of the cirrhosis and even cure the excess of fibrous tisue. My request is, if is possible, to give me a mail adress of one of the researchers because i whant to ask him/ her if there is a drug on the market and how i can secure it and buy it from U.S.A. The name of one of the researchers is Martina Buck, Ph.D. My e-mail adress is: adi_prisacariu@yahoo.com. I thank you with anticipation!
    Your’s Adrian Prisacariu

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