University of California, San Diego researchers have proven in animal studies that fibrosis in the liver can be not only stopped, but reversed. Their discovery, to be published in PLoS Online on December 26, opens the door to treating and curing conditions that lead to excessive tissue scarring such as viral hepatitis, fatty liver disease, cirrhosis, pulmonary fibrosis, scleroderma and burns.
Six years ago, the UC San Diego School of Medicine research team discovered the cause of the excess fibrous tissue growth that leads to liver fibrosis and cirrhosis, and developed a way to block excess scar tissue in mice. At that time, the best hope seemed to be future development of a therapy that would prevent or stop damage in patients suffering from the excessive scarring related to liver or lung disease or severe burns.
In their current study, Martina Buck, Ph.D., assistant professor of medicine at UCSD and the Veterans Affairs San Diego Healthcare System, and Mario Chojkier, M.D., UCSD professor of medicine and liver specialist at the VA, show that by blocking a protein linked to overproduction of scar tissue, they can not only stop the progression of fibrosis in mice, but reverse some of the cell damage that already occurred.
In response to liver injury – for example, cirrhosis caused by alcohol – hepatic stellate cell (HSC) activated by oxidative stress results in large amounts of collagen. Collagen is necessary to heal wounds, but excessive collagen causes scars in tissues. In this paper, the researchers showed that activation of a protein called RSK results in HSC activation and is critical for the progression of liver fibrosis. They theorized that the RSK pathway would be a potential therapeutic target, and developed an RSK inhibitory peptide to block activation of RSK.
The scientists used mice with severe liver fibrosis – similar to the condition in humans with cirrhosis of the liver – that was induced by chronic treatment with a liver toxin known to cause liver damage. The animals, which continued on the liver toxin, were given the RSK-inhibitory peptide. The peptide inhibited RSK activation, which stopped the HSC from proliferating. The peptide also directly activated the caspase or “executioner” protein, which killed the cells producing liver cirrhosis but not the normal cells.
“All control mice had severe liver fibrosis, while all mice that received the RSK-inhibitory peptide had minimal or no liver fibrosis,” said Buck.
Buck explained that the excessive collagen response is blocked by the RSK-inhibitory peptide, but isn’t harmful to the liver. “The cells continue to do their normal, healing work but their excess proliferation is controlled,” Buck said. “Remarkably, the death of HSC may also allow recovery from liver injury and reversal of liver fibrosis.”
The researchers found a similar activation of RSK in activated HSC in humans with severe liver fibrosis but not in control livers, suggesting that this pathway is also relevant in human liver fibrosis. Liver biopsies from patients with liver fibrosis also showed activated RSK.
The study expands on work reported in 2001 in the journal Molecular Cell announcing that a team led by Buck had found that a small piece of an important regulatory protein called C/EBP beta was responsible for fibrous tissue growth, or excessive scar tissue following injury or illness. When normal scarring goes awry, excessive build-up of fibrous tissue can produce disfiguring scars or clog vital internal organs and lead to serious complications. Buck and colleagues developed a mutated protein that stopped this excessive fibrous tissue growth.
“Six years ago, we showed a way to prevent or stop the excessive scarring in animal models,” said Buck. “Our latest finding proves that we can actually reverse the damage.”
Worldwide, almost 800,000 people die from liver cirrhosis each year, and there is currently no treatment for it. Excessive tissue repair in chronic liver disease induced by viral, toxic, immunologic and metabolic disorders all result in excessive scar tissue, and could benefit from therapy developed from the UCSD researchers’ findings.
The research was supported by grants from the National Institutes of Health, the Department of Veterans Affairs and UCSD’s Medical Research Foundation. Buck is the recipient of a Howard Temin Award from the National Cancer Institute.
From http://www.ucsd.edu
this post may be good for you
http://siroz.gen.tr/siroz-hastaligi.html
how will i know that cirrohsis is reversing? Is ascite curable in cirroshis?
Hi Annie. Have u found out abt the RSK as I need it for my mother. She is suffering. Pls revert to me
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I would like to know if any supplement company is manufacturing this RSK inhibitory peptide. They do not mention a name or possible chemical component to this peptide so it will be hard to track down.
In the mean time quite drinking, quit eating processed foods, start to eat whole foods and buy a juicer.
The following protocol may slow down the progression of the disease for some individuals.
1/2 lemon and water 1st thing in the morning
Branch Chain amino acids 1 heaping tsp per day – empty stomach
Milk Thistle – 800 to 1200 mg per day ( capsules)empty stomach
Same – 400 mg 3 to 4 times per day empty stomach
Vitamin C 3000mg per day
B12 1000mcg to 5000mcg per day sublingual – empty stomach
Folic Acid 400 – 800mg – with food
B6 100+ mg per day. – with food
***Do not take niacin ( B3) take all other B vitamins individually
Fiber – like psyllium powder
Lots of water
Eat well as malnutrition is a big problem with this disease. Protein is very important so if you are a vegan or veggie please break it by at least incorporating the Branch Chain Amino Acids.
Good luck
Thank you for all the Practical, Useful, Accurate info. Really.
Also, have you considered the following:
Alpha-lipoic acid 800 – 1200 mg / day total (400 x 2 – 3 / day)
This helps the endothelial cells, also many other benefits. Needed by damaged livers, it’s a prescription included in liver disease in Germany! OTC here, Walmart.
Grape Seed Extract –Wonderful Antioxidant $7.00 Walmart 2 caps w/food 3xday
Choline 2 to 4 tabs/ caps per day.
Melatonin, up to 20mg at a time, 3 x daily….strong antifibrotic, antioxidant!
No iron in Multivitamin. Especially men.
Modified Citrus Pectin, reduces Galectin-3, trials show reversal of liver fibrosis. see NIH.Gov website, key in modified citrus pectin, cirrhosis and galectin-3. You will learn a lot. Empowerment over this illness thru self-education; it works.
If platelets above 100,000, research gingko biloba, korean panax ginseng,
ginger. All 3 are shown to reverse liver fibrosis. It’s at NIH.gov also. By the way, NIH is the NATIONAL INSTITUTES OF HEALTH. They work with FDA and pharmaceutical co’s. to present clinical trial results, etc.
Magnesium (over 70% of U.S. is deficient) $4.00 Walmart. 600 mg per day. Helps Cure constipation. Rids body of toxic rotting poop. In Cirrhosis, an inflammatory and vascular disease, it’s important to be careful not to strain when trying to poop. I had colonoscopy and butt surgery same day as variceal endoscopy. Hopefully, since i was out (general anesthesia), they did my throat first.:))
I was almost dead for a week 3 years ago after the gastric/variceal hemorrhage. Now, according to formulas, I should have about 17 years, EVEN though I started as End Stage….Stage 4 Cirrhosis. Hope and Prayers, Love and Information, Genuine Care for You ABOUNDS. There is Information and CCCCCheap, over the counter supplementation along with generic medicine for virtually ALL of Us. Dr. Arshad is in Bowling Green, KY. Gastroenterologist. Limit radiation, xrays, dye contrast . check 2x yr. for liver cancer…find hospital with charity if uninsured, low income. If platelets below 60,000 prefer gym machines AND Elastic Bands to free weights. Remember, no straining. Caution lifting 1 yr. olds, like my nephew at 25 lbs.
Focus on the solution. Set some goals. We’re here for a long time. Do what you can the second you feel well enough to do so. There can be bumps in the road. Get ready. Receive new diagnosis, information…then move forward.
Be thankful for the energy and health you have and use it. Help someone less fortunate. Because you can. and it will make you both feel uplifted.
love to all, mike
so, whens this supose to happen?they have been making lots of claims that there close to curing lots of diseses like diabetes and aids,but i dont see it happening there allways making these kind of claims.
so, whens this supose to happen?they have been making lots of claims that there close to curing lots of diseses like diabetes and aids,but i dont see it happening there allways making these kind of claims.
I’m so glad to see someone else sees what I see. People have no idea that they are being mislead; all in the name of money. Yes, there are cures! I’ll give you one example of the bullshit in this country… Kidney Stones. It has been known for at least 20 years that a natural gut bacteria (pro-biotic) called ‘Oxalobacter Formigenes’ prevents clacium oxalate stones when present in the human gut. It is normally present, however, certain antibiotics can wipe it out leaving you vulnerable to these stones. Put it up on the “more studies needed shelf”…….
I am currently reversing my cirrhosis, my numbers all came down drastically these past few months, and I am not “taking” any cure. My doc put me on an ALL ORGANIC diet, no alcohol, no preservatives, etc. That’s it. (well, exercise, but they say that for EVERYTHING).
The liver is regenerative, as everyone tells me, and mine seems to be. If you are looking at liver damage or disease, I highly recommend the all organic lifestyle. I’ve been on it since the summer, and it’s only 6 months later that my numbers are all within normal limits.
Good luck to you.
What stage was you diagnosed. My husband was diagnosed stage four. The medical field offers me no hope. We lost our insurance along with his job. We are now trying alternative medicine. He seems to feel better and he definately looks better.
My father died today of liver Cirrhosis 11 months after being diagnosed with it. What an ugly, cruel death to watch. Rest in peace father, and god bless.
Good luck top the rest of you guys out there.
Hi, I had 2 liver function test with normal results. I drank heavy for 7 years and worry about damage. Are the test reliable? What can I do to heal up? I quit drinking almost 2 months ago. Many thanks!
We have a plant juice which is very active agaginst diabetic. But when the plant part is kept for few days, few microorganism grow inside plant part. The contaminated plant juice also reduces Blood glucose level of mouse but seriousely affected the liver and within 12 hours the treated mice died. On the other hand the fresh plant juice treated mice survive.
This juice prevent alloxan action to induce diabetic on mice. This is a great finding about this plant juice.
We are now searching the cause of such toxicity. We are also trying to find out whether this juice could recover diabetic induced mice to normal. Since it reduces blood sugar level and lipid profile of the alloxan induced diabetic mice and also prevent alloxan action in the process of inducing diabetic, we are expecting a good antidiabetic drug from it. This drug will not only control diabetic but may cure diabetic diseases.
Dr.Md. Anwar Ul Islam
Professor
Department of Pharmacy
University of Rajshahi
Rajshahi-6205
Bangladesh.
Email: profanwarulislam@yahoo.com
the cure will sit on a shelf because like stated before no money in a cure just the toxic treatments how many times before have you heard of these posible cures that are just forgoten about its allways the same thing ten years there will be a cure but we have yet to even cure one person of any illness a true cure
Hello! My name is Adrian Prisacariu and i am a young doctor from Romania. My mother is suferring from Liver Cirrhosis and i discover on the internet that in your university a group of researchers have identified a sintetic protein that can stop the evolution of the cirrhosis and even cure the excess of fibrous tisue. My request is, if is possible, to give me a mail adress of one of the researchers because i whant to ask him/ her if there is a drug on the market and how i can secure it and buy it from U.S.A. The name of one of the researchers is Martina Buck, Ph.D. My e-mail adress is: adi_prisacariu@yahoo.com. I thank you with anticipation!
Your’s Adrian Prisacariu
Hi my name is john i have cirrhosis of the liver to did you get help for your mother? iam looking for that same help please get back to me
I’m very interested in the possibility of reversing cirrhosis. I wonder how many other trials will there have to be before the treatment will be available to the public? Because, currently the only treatment available for “cirrhosis” is liver transplantation and not everyone may either be willing to have it or unable to, due to other health conditions. And unfortunately there isn’t any sort of liver dialysis available yet, although I heard that a product called Sepet is already in clinical trials. But even so – this would be a tremendous boost to the treatment of liver diseases.
Hi did you get any response as to when such a drug would become available for humans?
Thanks
hi my name is Rishi Bhanot and my father is having this cirrhosis of liver. I am very interested in any such medication if atall available which can help in reversing the damages already done or atleast which can improve his condition to lead reasonably good quality life. Currently he is facing the complications of ascites and encephalopathy.
I would really appreciate if i can get any help.
Thanks alot in advance!
Can contact me on rishibhanot@yahoo.com or
+91 9910036002
If there is a type of medication that can be taken to reverse cirhosis of the liver, can people who have developed Diabetes II from the disease be able to reverse it too? I would like to know who I need to refer these kind of questions to.? So if anyone knows would you please let me know? Also, can I ask my transplant center/drs. what they think? Best of luck to everyone. Recovering from cirrhosis without surgery would be great! How soon could this become a alternative. Please email me at shannonc36@yahoo.com
Best regards.
Hi,
My name is Ezani from Malaysia. My father has cirrhosis. Kindly help me please if you have the solution. contact me at ezaniafzan@gmail.com. Thank you
My father has cirrhosis due to blood transfusion. He is very bad right now, and is currently in hospital with renal failure, he is recovering but the ascetis is not decreasing ….
Need to know if this solution works and is available…..
if yes where can one get it and how soon???
please revert.
Gajendra
Bombay India
please publish more on reversal of liver cirrhosis thank you robin
It will probably be awhile before this or any drug treatment for cirrhosis becomes available. In the meantime, try to eat well. Silymarin (milk thistle extract) can also help to protect the liver from further damage, and BCAA’s (branched chain amino acids) and whey based supplements as used by bodybuilders can help prevent muscle wasting. Red meats,
salt, and excess vitamin A should be avoided.
Sulfasalazine, a drug commonly used for Crohn’s disease, has been tried with some success in reversing cirrhosis. Stronger analogues have also been synthesized and are under investigation. Such experimental drug regimes always require close medical supervision and monitoring and may also carry some grave risks including death, but for those with advanced cirrhosis and little or no chance of a transplant, they may be an option. Small interfering RNA (si-RNA) is also under study. The research is very promising as mechanisms for potential reversal of the disease are now being discovered, but from research to market typically takes many years.
For anyone desperately trying to save a loved one please be careful and don’t get scammed by false claims for miracle cures. There are at this time no drugs or herbal remedies known to cure cirrhosis. Although some may be helpful, many will do more harm than good. I would know. I’ve worked for a few international pharmaceutical companies. I’m an organic chemistry, biochem, herb and nutrition nut and I’ve spent
years looking for a cure. The love of my life is still dying of cirrhosis and I would do anything to help, but all I can do is pray.
Of course we may yet discover some other natural-source protein(s) that have the same effects in humans as the mutated protein successfully used in mice to reverse cirrhosis. Who knows? God is great. Keep the Faith.
Namaste.
Did you try Oxymatrine?
You have given me some very needed hope>GOD BLESS YOU AND YOURS!!
Japan has reversed Cirrhosis and so has England but my guess is we won’t see these cures as I believe it is all about the money in this greedy country!
can you cite the sources for this info. Journal articles would be prefered
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0001372
If your father has cirrhosis due to hepatitis c from a transfusion I’d look into thymic protein A by Dr. Beardsley. Many claim to be helped from it. God Bless.