A study in the January issue of the journal Drug and Alcohol Dependence reports that a long-lasting depot medication appears safe and effective for treatment of narcotic addiction. In the study a single injection prevented withdrawal discomfort for 6 weeks in heroin-dependent patients, reduced the effects of injected opiates, and provided a comfortable detoxification as it gradually wore off. From the Elsevier Science :One-shot addiction treatment shows promise
Long-lasting depot medication appears safe and effective for treatment of narcotic addiction
A study in the January issue of the journal Drug and Alcohol Dependence reports that a long-lasting depot medication appears safe and effective for treatment of narcotic addiction. In the study a single injection prevented withdrawal discomfort for 6 weeks in heroin-dependent patients, reduced the effects of injected opiates, and provided a comfortable detoxification as it gradually wore off.
The study medication was an experimental injectable sustained-release depot formulation of the medication buprenorphine. The injection is a suspension of biodegradable microcapsules each containing small amounts of the buprenorphine medication. As the microcapsules gradually disintegrate they provide a long-duration sustained release of buprenorphine. A tablet form of buprenorphine that is taken by holding it under the tongue is already used in the U.S. and around the world as an analgesic and as a treatment for opioid dependence; the tablet normally needs to be taken every day. The recent study was the first to test this new long-lasting depot formulation in humans. The study examined the safety and pharmacokinetics of the depot medication, and tested its effectiveness for reducing the opioid withdrawal syndrome and for reducing the effects of opioid challenge injections.
Participants were five volunteer physically dependent heroin abusers. In a residential laboratory setting the heroin abusers each had their narcotics abruptly stopped and was instead given a depot injection of 58 mg of buprenorphine. For the next 6 weeks the patients were assessed repeatedly for signs and symptoms of the opioid withdrawal syndrome. In addition, the volunteers received weekly challenge injections of the opioid hydromorphone (Dilaudid) to test whether their sensitivity to opioids was reduced by the depot buprenorphine treatment.
The results were promising both for prevention of the opioid withdrawal syndrome and for blockade of the opioid high from the hydromorphone challenge injections. No significant withdrawal syndrome occurred and no patient required additional medications. In addition, the effect of the opioid challenge injections appeared considerably reduced. No significant side effects were reported.
The ability of a single medication dose to have beneficial effects over 4 to 6 weeks is a significant finding for the treatment of opioid dependence. Further research will need to determine how this new product can best be used.
The depot medication holds promise both as a one shot detoxification treatment and as an alternative maintenance treatment. With the recent advent in the U.S. of office-based addiction treatment with sublingual buprenorphine, this longer-acting formulation could increase patient adherence to treatment, ease the visit burden on both patients and providers, and make treatment more accessible.
The study was conducted by researchers at the Behavioral Pharmacology Research Unit, Department of Psychiatry and Behavioral Sciences, of the Johns Hopkins University School of Medicine in Baltimore, Maryland, under research grant support from the National Institute on Drug Abuse. The depot medication was developed and produced by Biotek, Inc. of Woburn, Massachusetts.
The study appeared in the journal Drug and Alcohol Dependence. Authors were Bai-Fang X. Sobel, Stacey C. Sigmon, Rolley E. Johnson, Ira A. Liebson and George Bigelow from the Johns Hopkins University School of Medicine, and Elie S. Nuwayser and James H. Kerrigan from Biotek, Inc. The full text of the article is available online at http://dx.doi.org/10.1016/j.drugalcdep.2003.08.006.
It is an annual, of up to 1 meter of height, little graft plant, with the oblong leaves, sinuosodentadas in the edges, with the petals of several colors, targets, pink, red and violets, this indicates findrxonline in article, with a dark spot in the base. The fruit is a capsule of good size. It is spread by the south of Europe, North Africa, central and South Asia and America. It exists in the Iberian Peninsula, in addition to the narcotic, another plant with similar effects, the Chelidonium majus, well-known with the names of golondrinera grass or the wanderers, verruguera grass and celidueña. Latex removes rarely from the incisions of the immature fruits and of other parts of the plant. This latex coagulates in contact with the air. The opium is a mixture of ranges, different resins, sugars and other substances, between which 20 have pharmacological activity, almost all alkaloids like: morphine, codeine, thebaine, narcobathtub, narceína and papaverina; most important of all of them it is the morphine, contained in the opium in variable proportion (3-22 %) and to which it confers his main qualities.
Most people who have been diagnosed with chronic depression and anxiety have probably been prescribed modern anti-depression and anxiety medications such as Prozac, Celexa, Zoloft, Paxil and other SSRI related medications which seem to be the favorite choice of every modern doctor of the 21st century, this indicates findrxonline in his article about depression.
Unfortunately these new anti-anxiety and depression medications do not come without side effects and only a small percentage of its users reports that these medications do indeed balance their moods to the point where they can say they truly feel comfortable over longer periods of time.
That’s great news, BJS! I know a lot of people who have always wanted to break free from their addiction. But because they suffer adversely from withdrawal effects, they find it hard to deal with their addiction treatment. Nice thing that Science has come up with a one-shot addiction treatment. However, as you mentioned in your post, this medication has yet to undergo more tests. I just wish that this new line of treatment will be successful for the good of all. Thanks for a very useful information!