NEW YORK — SEPTEMBER 15, 2009 — Results of a clinical trial published today in Circulation: Cardiovascular Interventions demonstrate that an infusion of blood that is “supersaturated” with oxygen (SS02) can reduce the amount of damaged heart muscle immediately following a life-threatening heart attack.
“The benefit of this therapy increased with the scope of the heart attack,” said Gregg W. Stone, M.D., lead author and professor of medicine at Columbia University College of Physicians and Surgeons and director of cardiovascular research and education in the Center for Interventional Vascular Therapy at NewYork-Presbyterian Hospital/Columbia University Medical Center. Dr. Stone is also the immediate past chairman of the Cardiovascular Research Foundation in New York. “The data show that heart muscle can be saved even after severe heart attack.”
The AMIHOT-II study focused on patients having the most serious types of heart attacks — those with anterior ST-segment elevation myocardial infarctions (STEMIs) ? and on patients treated within 6 hours. Of the 733,000 Americans who suffer acute coronary syndromes (i.e. heart attack or chest pain) each year, 361,000 (almost half) have a STEMI, according to the American Heart Association. When a large area of the heart is damaged, heart failure is more likely, and catheter-based percutaneous coronary intervention is a procedure that can effectively open blocked arteries in STEMI patients, Dr. Stone said.
In the trial, the “supersaturated” oxygen was delivered via catheter directly to the area of the heart muscle affected by the heart attack. The size of the “infarct zone,” or the amount of damaged tissue, was significantly reduced in the patients that received the “supersaturated” oxygen.
Data from the study show that the median size of the “infarct zone” was 20 percent in the patients that received the “supersaturated” blood and 26.5 percent in the control group.
In addition, at 30 days after the treatment a key safety measure — the rates of major adverse cardiac events ? were not statistically different between the two groups.
The Cardiovascular Research Foundation (CRF) is an independent, academically focused nonprofit organization dedicated to improving the survival and quality of life for people with cardiovascular disease through research and education. Since its inception in 1991, CRF has played a major role in realizing dramatic improvements in the lives of countless numbers of patients by establishing the safe use of new technologies and therapies in the subspecialty of interventional cardiology and endovascular medicine. For more information, please visit www.crf.org.
Columbia University Medical Center provides international leadership in basic, pre-clinical and clinical research, in medical and health sciences education, and in patient care. The medical center trains future leaders and includes the dedicated work of many physicians, scientists, public health professionals, dentists, and nurses at the College of Physicians and Surgeons, the Mailman School of Public Health, the College of Dental Medicine, the School of Nursing, the biomedical departments of the Graduate School of Arts and Sciences, and allied research centers and institutions. Established in 1767, Columbia’s College of Physicians and Surgeons was the first institution in the country to grant the M.D. degree and is now among the most selective medical schools in the country. Columbia University Medical Center is home to the most comprehensive medical research enterprise in New York City and state and one of the largest in the United States. Columbia University Medical Center is affiliated with NewYork-Presbyterian Hospital, the nation’s largest not-for-profit hospital provider. For more information, please visit www.cumc.columbia.edu.
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