Wandering minds associated with aging cells


November 17, 2012
Brain & Behavior, Uncategorized

Scientific studies have suggested that a wandering mind indicates unhappiness, whereas a mind that is present in the moment indicates well-being. Now, a preliminary UCSF study suggests a possible link between mind wandering and aging, by looking at a biological measure of longevity.

In the study, telomere length, an emerging biomarker for cellular and general bodily aging, was assessed in association with the tendency to be present in the moment versus the tendency to mind wander, in research on 239 healthy, midlife women ranging in age from 50 to 65 years.

Being present in the moment was defined as an inclination to be focused on current tasks, while mind wandering was defined as the inclination to have thoughts about things other than the present or being elsewhere.

According to the findings, published online on Nov. 15 in the new Association for Psychological Science journal Clinical Psychological Science, those who reported more mind wandering had shorter telomeres, while those who reported more presence in the moment, or having a greater focus and engagement with their current activities, had longer telomeres, even after adjusting for current stress.

Telomeres are the DNA-caps that protect the ends of chromosomes, preventing them from deteriorating or fusing with neighboring chromosomes. Telomeres typically shorten with age and in response to psychological and physiological stressors. In research pioneered at UCSF, scientists have discovered that telomere shortness predicts early disease and mortality.

As the study assessed mind wandering and telomeres at the same time, the researchers don’t yet know whether mind wandering leads to shorter telomeres, whether the reverse occurs, or some common third factor is contributing to both.

Mindful meditation interventions, which promote attention on the present with a compassionate attitude of acceptance, lead to increases in some aspects of health. Previous studies have found that they are associated with increased activity of an enzyme known as telomerase, which is responsible for protecting and in some cases, replenishing telomeres.

Along with the new UCSF study, these findings support the possibility that a focus on the present may be part of what promotes health measurable at the cellular level, the researchers said.

“Our attentional state—where our thoughts rest at any moment – turns out to be a fascinating window into our well-being. It may be affected by our emotional state as well as shape our emotional state,” said Elissa Epel, PhD, associate professor of psychiatry and lead author on the study. “In our healthy sample, people who report being more engaged in their current activities tend to have longer telomeres. We don’t yet know how generalizable or important this relationship is.”

Moving forward, Epel, along with Eli Puterman, PhD, a psychologist in the UCSF Department of Psychiatry, and colleagues are developing a series of classes to promote more mindful presence, to see if this intervention protects telomere maintenance or even lengthens telomeres.

In the current study, participants self-reported a tendency to mind wander, and were measured for aspects of psychological distress and well-being. The sample was highly educated and had a narrow range of both chronological age and psychological stress (most were low stress), all of which might have contributed to the ability to detect this relationship, Epel said.

The study is the first to link attentional state to telomere length and to control for stress and depression, Epel said. Previous studies have shown links between telomere length and particular types of stress and depression. Since this study relied on self-reported attentional state, she said, further studies directly measuring presence and mind wandering will be needed.

“This study was a first step and suggests it’s worth delving into understanding the link between mind wandering and cell health to get a better understanding of whether there is causality and reversibility,” said Epel. “For example, does reducing mind wandering promote better cell health? Or are these relationships just reflective of some underlying long-standing characteristics of a person?”

“Results suggest the possibility that the attitude of acceptance of negative experiences might be one of the factors that promotes greater ability to be more present – to be okay with one’s current experience and not avoid the unpleasant aspects of everyday experiences,” she said.

“A number of emotion theories suggest that greater attentional control leads to less suppression of negative emotions, and thus less of the rebound effect of unsuccessful suppression,” said Wendy Berry Mendes, PhD, associate professor and Sarlo/Ekman Endowed Chair of Emotion at UCSF and co-author on this study. “Alternatively, attentional control may help us interpret emotions in a more constructive way, what we call ‘positive reappraisals.’ Such styles of thinking have been associated with healthy physiological states.”

In addition to Epel, Mendes and Puterman, co-authors on this study include Jue Lin, UCSF research biochemist in the Department of Biochemistry and Biophysics; Elizabeth Blackburn, PhD, UCSF molecular biologist and Alanie Lazaro, UCSF laboratory manager in the Department of Psychiatry.

Research on telomeres, and the enzyme that makes them, was pioneered by three Americans, including Blackburn, who co-discovered the telomerase enzyme in 1985. The scientists received the Nobel Prize in Physiology or Medicine in 2009 for this work.

Epel, Blackburn and Lin are co-founders of Telome Health Inc, a telomere measurement company.


2 Responses to Wandering minds associated with aging cells

  1. Cheyenne November 19, 2012 at 9:00 am #

    This gives me an idea.. does this therefore mean that there may be a possibility in reversing the effects of a shortening of telomeres and perhaps rebuilding them to prolong life? (though by doing so may not be the most beneficial circumstances, nevertheless it is just the mere idea and thought that it could be done.) Also, since this is noted that for whatever reason, those who have wondering minds typically are more depressed and undergo more stress [ in a less healthy way than those who maybe aren't depressed] would cope, it makes me wonder, is there a link between those with illnesses such as manic depressive illness, and other mood disorders associated with depression? If so what is the link and how strong is it? What does that information mean?

  2. hrr November 17, 2012 at 9:35 am #

    First let me accept that I am not qualified in interacting on this subject. But considering the approach to determine the cause or result of wandering minds I feel that the wondering minds can be stilled by positive approach towards life. There are many instances in the history where the person with atrocious activities and bad temper could become a sane person and contribute to the development of the human kind. Valmiki the great poet who wrote the epic Ramayana was a head hunter and robber. On the advice of the saint Narada he was drawn into meditation. After some time he was a transformed man and became great by narrating the story’ March of Rama’. Many people, even now , accept saintly living because of troubles in the family life.

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