How predictable are new chemical reactions that have never been done before?

There occasionally occurs a paradigm shift in the way that particular problems are recognized and solved. It often takes years and even decades before these new ideas are incorporated into the prevailing scientific thought. One reason for this may be because of the inability to effectively communicate those ideas to the rest of the world. When such paradigm shifts take hold and begin to grow, there's a critical point where the idea is tested by suitable independent experimental scientists. These are often the unsung heroes of newer scientific ideas and technologies breaking through to recognition and eventual acceptance. So far the links between mathematics, physics, chemistry and biology seem rather esoteric and remote, yet we all accept that we are physical beings subjected to the same physical laws that govern the universe around us. So why haven’t we made greater progress toward a more direct connection to our underlying physical relationship with the universe? Perhaps we have a resistance to such knowledge. We may not really want to know these things unless we can be more mentally and spiritually prepared to accept them. Not everyone may be able to accept the direct scientific evidence for these connections and not every mind is prepared to understand how these connections occur, but for those who wish to explore these connections consider the following link that may change the way that you view how mathematics, physics and chemistry meet biology - http://ombamltine.blogspot.com/2008/05/welcome.html