Link between vitamin D status, breast cancer shown
Using newly available data on worldwide cancer incidence, researchers at UCSD have shown a clear association between deficiency in exposure to sunlight, specifically ultraviolet B (UVB), and breast cancer. UVB exposure triggers photosynthesis of vitamin D3 in the body. This form of vitamin D also is available through diet and supplements.
Approximately 1,150,000 cases and 410,000 deaths from breast cancer occur annually worldwide, including 215,000 new cases and 41,000 deaths in the United States.
The study is published in the May-June 2008 issue of The Breast Journal.
“This is the first study, to our knowledge, to show that higher serum levels of vitamin D are associated with reduced incidence rates of breast cancer worldwide,” said Cedric F. Garland, Dr. P.H., professor of Family and Preventive Medicine in the UCSD School of Medicine, and member of the Moores UCSD Cancer Center.
This paper used worldwide data only recently available through a new tool called GLOBOCAN, developed by the World Health Organization’s International Agency for Research on Cancer. GLOBOCAN is a database of cancer incidence, mortality and prevalence for 175 countries.
The researchers created a graph with a vertical axis for breast cancer incidence rates, and a horizontal axis for latitude. The latitudes range from -50 for the southern hemisphere, to zero for the equator, to +70 for the northern hemisphere. They then plotted age-standardized incidence rates for 175 countries according to latitude. The resulting chart was a parabolic curve that looks like a smile.
“In general, breast cancer incidence was highest at the highest latitudes in both hemispheres,” said Garland. “Even after controlling for known variables such as meat, vegetable and alcohol intake, cigarette consumption, weight, fertility and others, the inverse association of modeled vitamin D status with breast cancer incidence remained strong.”
In the paper, the authors caution that this was a study of aggregates, or countries, rather than individuals; findings that apply to aggregates may not apply to individuals. They recommend further research to study individuals for the effect of vitamin D from sunlight, diet and supplements on the risk of breast cancer.
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May 15, 2008
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Comments
Ryan W.
June 27, 2008 by Anonymous, 1 year 19 weeks ago
Comment id: 30837
I found a blog post that makes an interesting argument that some of the studies showing lower Vit. D linked to increased mortality in osteoporosis and autoimmune disease are showing an effect of infection and Vit. D receptor disregulation rather than simple deficiency.
You won't find any research that shows vitamin D + calcium increases bone density above calcium alone. Blood levels of calcium, yes. But not bone density.
Many people with low 25D have high 1,25D which is a product of 25D
That argues against deficiency in some cases. And in favor of infection + occasionally dysregulation of the Vitamin D Receptor resulting in overproduction of
1,25D from 25D (which leads to low levels of 25D, which appears like deficiency)
bacteriality.com/2007/09/15/vitamind/
They say high levels of 25D deactivates the Vitamin D receptor based on molecular modeling, though. That part I question. How much D3 supplementation does it take to maximize cathelidicin production?
I cannot find an answer to that question, and it should be simple.
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