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Tobacco smoke exposure before heart transplantation may increase the risk of transplant failure

A study conducted at the University of Maryland School of Medicine in Baltimore provides the first direct evidence that cigarette smoke exposure prior to a heart transplant in either the donor, recipient, or both, accelerates the death of a transplanted heart.

Alarming trend -- antiviral therapy to treat hepatitis C is declining in the US

Researchers from the University of Michigan determined that only 663,000 of the approximately 3.9 million Americans with hepatitis C virus (HCV) infection received antiviral therapy between 2002 and 2007. Treatment rates appear to be declining, in part because only half of the patients know they are infected.

Metobolomics uncovers key indicators of nonalcoholic fatty liver disease

A recent metobolomics study by researchers from Virginia Commonwealth University Medical Center in Richmond found that impaired peroxisomal oxidation of polyunsaturated fatty acids (PUFA) is associated with the progression of nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH).

Surface bacteria maintain skin's healthy balance

On the skin's surface, bacteria are abundant, diverse and constant, but inflammation is undesirable. Research at the University of California, San Diego School of Medicine now shows that the normal bacteria living on the skin surface trigger a pathway that prevents excessive inflammation after injury.

Women at risk from vitamin A deficiency

Almost half of UK women could be suffering from a lack of vitamin A due to a previously undiscovered genetic variation, scientists at Newcastle University have found.

The team, led by Dr Georg Lietz, has shown that almost 50 per cent of women have a genetic variation which reduces their ability to produce sufficient amounts of vitamin A from beta-carotene.

Scientists discover cells that control inflammation in chronic disease

A new type of immune cell that can be out of control in certain chronic inflammatory diseases, worsening the symptoms of conditions like psoriasis and asthma, is described for the first time this week in the Journal of Clinical Investigation.

Nanoparticles used in common household items caused genetic damage in mice

Titanium dioxide (TiO2) nanoparticles, found in everything from cosmetics to sunscreen to paint to vitamins, caused systemic genetic damage in mice, according to a comprehensive study conducted by researchers at UCLA's Jonsson Comprehensive Cancer Center.

Penn study finds that antioxidant found in vegetables has implications for treating cystic fibrosis

PHILADELPHIA -- Scientists at the University of Pennsylvania School of Medicine discovered that a dietary antioxidant found in such vegetables as broccoli and cauliflower protects cells from damage caused by chemicals generated during the body's inflammatory response to infection and injury.

Largest gene study of childhood IBD identifies 5 new genes

In the largest, most comprehensive genetic analysis of childhood-onset inflammatory bowel disease (IBD), an international research team has identified five new gene regions, including one involved in a biological pathway that helps drive the painful inflammation of the digestive tract that characterizes the disease.

Tiny particles can deliver antioxidant enzyme to injured heart cells

Researchers at Emory University and the Georgia Institute of Technology have developed microscopic polymer beads that can deliver an antioxidant enzyme made naturally by the body into the heart.

Injecting the enzyme-containing particles into rats' hearts after a simulated heart attack reduced the number of dying cells and resulted in improved heart function days later.

Aileron collaborates study in Nature: Stapled peptides inhibit Notch1 transcription factor

CAMBRIDGE, MA -- November 11, 2009 -- Aileron Therapeutics, a biopharmaceutical company leading the development of a new class of drugs called Stapled Peptides, announced today that its collabora

Ice cream researchers making sweet strides with 'functional foods'

COLUMBIA, Mo. -- A comfort food, a tasty treat, an indulgence -- ice cream conjures feelings of happiness and satisfaction for millions.

MicroRNA’s Role in Interferon’s Contribution to Inflammation

November 6, 2009 by Lupus Foundatio...

Interferons (IFNs) are proteins produced by immune cells when the immune system is activated.

Oral contraceptives may benefit women with asthma

New research shows that during natural menstrual cycles, women with asthma who were not taking oral contraceptives (OC) had lower exhaled nitric oxide levels (eNO), a marker of airway inflammation



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