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Predicting fatal fungal infections

June 15, 2009 -- (BRONX, NY) -- In a study published in The Journal of Infectious Diseases, researchers from Albert Einstein College of Medicine of Yeshiva University have identified cells in blood that predict which HIV-positive individuals are most likely to develop deadly fungal meningitis, a major cause of HIV-related death.

What is the role of reactive oxygen species in ethanol-mediated cell death of polarized hepatic cells?

Liver disease that results as a consequence of alcohol abuse is a major medical problem worldwide. Ethanol consumption leads to a variety of liver alterations including the accumulation of fat, inflammation of the liver, as well as the presence of scar tissue. However, how these events happen after drinking alcohol are not well understood.

NEJM study points to new era in hepatitis C treatment

NEW YORK (June 4, 2009) -- For patients with the most common form of hepatitis C, the addition of a hepatitis C-specific protease inhibitor called telaprevir to the current standard therapy can significantly improve the chances of being cured, and it does it in half the time of standard therapy alone.

NewYork-Presbyterian/Columbia physician-scientists present at 2009 American Transplant Congress

NEW YORK (June 4, 2009) -- NewYork-Presbyterian Hospital/Columbia University Medical Center physician-scientists presented new research at the 2009 American Transplant Congress in Boston, May 30 to June 3. Topics included minimizing steroid exposure for liver transplant patients with hepatitis C; hypothermic machine perfusion vs.

Liver disease: Better monitoring, better prognosis

The latest research in liver disease being presented at Digestive Disease Week® 2009 (DDW®) has important implications for tracking disease development in patients and for current and future transplant recipients. Researchers are making great strides in diagnosing and treating liver disease.

Scientists explain how 'death receptors' designed to kill our cells may make them stronger

It turns out that from the perspective of cell biology, Nietzsche may have been right after all: that which does not kill us does make us stronger.

Liver disease 'shrunk' by blood-pressure drug

A blood-pressure medicine has been shown to reverse the effects of early-stage liver failure in some patients.

Newcastle University researchers analysed a small clinical trial of losartan, a drug normally prescribed for hypertension, on 14 patients in Spain, who had Hepatitis C.

Environmental pollution increases the risk of liver disease

CHICAGO, IL (May 29, 2009) - A new study is the first to show that there is a previously unrecognized role for environmental pollution in liver disease in the general U.S. adult population. This work builds upon the groups' previous research demonstrating liver disease in highly-exposed chemical workers.

Intestinal bacteria associated with non-alcoholic fatty liver disease

Intestinal permeability and an overgrowth of bacteria in the small intestine are both associated with nonalcoholic fatty liver disease (NAFLD). These findings are revealed in a new study in the June issue of Hepatology, a journal published by John Wiley & Sons on behalf of the American Association for the Study of Liver Diseases (AASLD).

New treatment option for patients with chronic hepatitis C

A new combination therapy of daily consensus interferon (CIFN) and ribavirin is effective for some people with chronic hepatitis C (HCV) who do not respond to standard therapy.

Some donor factors affect outcomes for HCV-positive liver transplant recipients

Two new studies address donor factors that could affect outcomes for liver transplant recipients, particularly those with chronic hepatitis C (HCV). One found that donor steatosis, or fat in the liver, does not affect liver disease progression or three-year survival in recipients with or without HCV.

Hyperferritinemia is another surrogate marker of advanced liver disease

High serum ferritin, being a hallmark of hereditary hemochromatosis , is frequently found in chronic hepatitis C, alcoholic or non-alcoholic steatohepatitis and non-alcoholic fatty liver disease patients . A study in Italy has investigated the link between ferritin and steatosis in a non-obese cohort of non-alcoholic patients.

p90RSK: A new therapeutic target for liver fibrosis?

Cirrhosis is a world wide, bad prognosis liver disease and characterized by excessive collagen deposition and liver function damage. In our previous work, p90RSK is observed significantly up-regulated in association with elevated collagen type I levels in rat liver fibrosis. But detail mechanism of this phenomenon is still unknown.

Study indicates cancer preventive effect for statins

Bethesda, MD (May 5, 2009) - The commonly used prescription statin drugs may have a protective effect in the prevention of liver cancer and lead to a reduction in the need for gallbladder removals, according to two studies published in Gastroenterology.

HIV positive and HIV negative patients have similar survival rates following liver transplant

Copenhagen, Denmark, Friday 24 April: HIV positive and HIV negative patients have comparable survival rates following liver transplant, according to new research presented today at EASL 2009, the Annual Meeting of the European Association for the Study of Liver in Copenhagen, Denmark.



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