A University of Washington study is the first to provide visualizations of tuberculosis infections in an intact living organism and reveals how tuberculous granulomas, the tight aggregates of macrophages that are the hallmarks of this infection, are formed within infected organisms (Macrophages are a specialized class of white blood cells that patrol tissues and ingest foreign particles, such as bacteria and viruses, as well as dead and dying cells. Macrophages provide the backbone of the immune system.)
Oncologists are testing a new technique called gene expression profiling that subtypes each breast cancer tumor by its genetic defects so that doctors can tailor their treatment to inhibit that particular tumor. The researchers believe the technique could spare millions of women from needlessly receiving toxic chemotherapy, and they are leading a national clinical trial to study gene profiling. "Currently, we have no predictive model to determine who will respond to hormonal therapies and who won't, so we prescribe chemotherapy as a backup measure to ensure the cancer's demise," said Matthew Ellis, M.D., Ph.D., director of the breast cancer program at Duke. "This one-treatment-fits-all approach leads to a huge amount of over treatment, with up to 50 percent of women unnecessarily receiving chemotherapy."
The federal government today published its biennial Report on Carcinogens, adding steroidal estrogens used in estrogen replacement therapy and oral contraceptives to its official list of "known" human carcinogens. This and 15 other new listings bring the total of substances in the report, "known" or "reasonably anticipated" to pose a cancer risk, to 228. Among the other new additions: wood dust and ultraviolet light.
An international team of researchers has used a gene test to identify certain patients with adult T-cell acute lymphoblastic leukemia (ALL) who can be successfully treated with chemotherapy alone and should not be subjected to the rigors of bone marrow transplants. The researchers found that these patients survived for at least three years after being treated with intensive chemotherapy. It was previously known that only slightly over half of the patients with this disease could be cured with chemotherapy. Adult ALL patients often undergo transplants in an effort to beat back the stubborn disease. Until now there was no way to identify those who have a more favorable outlook and shouldn't undergo risky bone marrow transplantation.
Cruise missiles have proven themselves in combat many times since the Gulf War, but the Navy would like to drive their cost down--the ones currently in service cost hundreds of thousands of dollars. The Office of Naval Research (ONR) has a program to use commercially-based equipment to build a "cruise-like" missile with good performance at a price ten times less than the norm. The new missile is called, appropriately, the Affordable Weapon.
Loneliness, lack of emotional support and lack of companionship or social support can leave elderly men and women vulnerable to heart problems. Dara Sorkin of the University of California, Irvine, and colleagues found that for every unit increase in loneliness as measured among older adults in their study, there was a threefold increase in the odds of being diagnosed with a heart condition.
Gastroenterologists at Mayo Clinic in Jacksonville, Fla., report photodynamic therapy (PDT) appears to destroy the abnormal tissue of Barrett's esophagus as well as superficial esophageal cancer. Here's how PDT works. Patients are given an injection of a photosensitizing drug called porfimer sodium (Photofrin). Cells in the body absorb this drug. Normal cells get rid of it, but the drug tends to collect in premalignant and malignant cells. Two days after the injection of Photofrin, physicians insert and endoscope into the sedated patient's esophagus. An endoscope is a thin, flexible tube with a miniature camera on its tip. Physicians deliver a specific wavelength of red laser light through the endoscope to the targeted cells. The laser light destroys the Photofrin-containing cells. Normal esophageal cells grow back in their place.
Forest dieback in the northeastern United States and neighboring areas in Canada has been more frequent, more persistent, and more severe during recent decades, research has shown. Now scientists have found springtime temperature swings have intensified in that region during the same period. A new study links these escalating freeze-thaw episodes, which are known to harm trees, to an atmospheric pressure imbalance over the North Atlantic.
Among teens in juvenile detention, nearly two thirds of boys and nearly three quarters of girls have at least one psychiatric disorder, a federally funded study has found. These rates dwarf the estimated 15 percent of youth in the general population thought to have psychiatric illness, placing detained teens on a par with those at highest risk, such as maltreated and runaway youth.
The Defense Advanced Research Project Agency (DARPA) and Defense MicroElectronics Activity (DMEA) along with three University of California campuses have established a new Center for Nanoscience Innovation for Defense, to get university advances in the nanosciences into defense contractors' hands as soon as possible.
Sure Santa Claus asks boys and girls what toys they want, but why they want them is a better question. The answer may have to do with a biological pre-wiring that influences boys' and girls' preferences based on the early roles of males and females. It's commonly believed that boys and girls learn what types of toys they should like based solely on society's expectations, but psychologist Gerianne Alexander's work with vervet monkeys is challenging that notion. Alexander examined the monkeys as they interacted with toys. She and her collaborator, Melissa Hines of the University of London, found that the monkeys' toy preferences were consistent along gender lines with those of human children. Though the monkeys had no concept of a "boy" toy and a "girl" toy, they still showed the same gender preferences in playing with the toys, Alexander says. That is, compared to female monkeys, male monkeys spent more time with "boy" toys, and the female monkeys, compared to their male counterparts, spent more time with "girl" toys.
Biodiversity worldwide may be decreasing, but at smaller scales it is increasing or at least changing in composition, suggesting the need for a dramatic shift in the current focus of ecological research. These changes may undermine the functioning of local ecosystems, according to an article in December's American Naturalist. The authors studied data collected on oceanic island land birds and plants. Records from islands are useful because they present discrete areas where additions and subtractions of species can be accurately determined. The article, "Species Invasions Exceed extinctions on Islands Worldwide: A Comparative Study of Plants and Birds," documents the fact that "land birds have experienced massive extinctions on oceanic islands, with many islands losing more than half of their native species," said Gaines. "On these same islands, however, many exotic bird species have become established, such that the total number of land bird species has remained relatively unchanged."
Using a computer code originally developed for combat simulation, researchers from the Lawrence Livermore National Laboratory are supplying the same expertise that analyzes concepts of operation, technology and training to emergency responders as a part of the Lab's role in homeland security. The Analytical Conflict and Tactical Simulation (ACATS) is an offshoot of the Joint Conflict and Tactical Simulation (JCATS) that the military uses for training, analysis, mission planning and mission rehearsal. JCATS also has been used to support actual military operations in places such as Panama and the Persian Gulf.
Healthy adults ages 18 to 29 are needed for a research study comparing the safety and effectiveness of two different vaccines for the prevention of the smallpox disease. The study will compare three dose levels of a new vaccine with the current, approved smallpox vaccine that was provided to all U.S. residents during the period of routine smallpox vaccination. The effectiveness of these trial vaccinations will be measured by observing whether or not there is a skin reaction, such as a blister, at the sight of the vaccination. A skin reaction is a typical response to smallpox vaccination. The response also will be measured by examining the size of the skin reaction and the time it takes for the blister to heal. Participants may become immune to smallpox, which would reduce or prevent infection with smallpox.
NASA's Galileo spacecraft continues to deliver surprises with the discovery that Jupiter's potato-shaped inner moon, named Amalthea, appears to have a very low density, indicating it is full of holes. "The density is unexpectedly low," said Dr. John D. Anderson, an astronomer at NASA's Jet Propulsion Laboratory, Pasadena, Calif. "Amalthea is apparently a loosely packed pile of rubble." The empty gaps between solid chunks likely take up more of the moon's total volume than the solid pieces, and even the chunks are probably material that is not dense enough to fit some theories about the origin of Jupiter's moons. "Amalthea now seems more likely to be mostly rock with maybe a little ice, rather than a denser mix of rock and iron," said JPL's Dr. Torrence Johnson, project scientist for Galileo.
