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Only 58 percent of patient care physicians in California are accepting new patients with HMO coverage, and the "California Model" of loose networks of private practice physicians organized into large managed care practice organizations is unraveling, according to University of California research. "California led the nation's charge into managed care. Our study of the state's physicians tells us that California has now sounded the retreat," said Kevin Grumbach, MD, director of the Center for California Health Workforce Studies. "Private physicians are starting to abandon HMOs, IPAs and managed care networks."
In an airplane hangar in Columbus, OH, some 80 tons of steel, electronics, and cryogenic equipment are about to come together -- all to deposit one ounce of aluminum as a near-perfect, whisper-thin coating on a giant telescope mirror. The successful operation of the coating system will represent a milestone in the construction of the Large Binocular Telescope (LBT), and a critical phase in Ohio State University 's participation in the LBT project.
A pivotal efficacy trial of an experimental vaccine designed to prevent genital herpes in women began enrolling volunteers this week. The study will determine the vaccine's ability to prevent genital herpes disease in women who are free of two common types of herpes simplex viruses (HSV): HSV-1 and HSV-2. The trial will eventually enroll 7,550 women in at least 16 sites in the United States.
Former Israeli Prime Minister Ehud Barak, a speaker at BioSecurity 2002, now underway in Las Vegas, discusses with Science Blog editor Ben Sullivan issues facing Israel and the Middle East in the biosecurity realm.
Beyond Iraq, to what extent do bioweapons represent a likely threat to Israel and other Middle East countries? Do you believe they are seen as a legitimate weapon by the powerplayers behind the intifada, for example, or does the region's concentrated geography actually play against the likelihood of their use?
Iraq is clearly the major player of bio-weapon in the region. Syria might be interested in it as a part of its "Strategic Answer" vis a vis the per claimed nuclear capabilities of Israel, namely as a deterrence element. Palestinian terror might not be able to use it on major scale for the reasons you have mentioned...
The ecological importance of phytoplankton, microscopic plants that free-float through the world's oceans, is well known. Among their key roles, the one-celled organisms are the major source of sustenance for animal life in the seas. Now, researchers at Scripps Institution of Oceanography in San Diego say that phytoplankton exert a significant and previously uncalculated influence on Earth's climate.
Researchers in Pittsburgh have made significant progress in identifying the first susceptibility gene for clinical depression, the second leading cause of disability worldwide, providing an important step toward changing the way doctors diagnose and treat major depression that affects nearly 10 percent of the population. Research results show significant evidence for linkage of unipolar mood disorders to a specific region of chromosome 2q33-35 in women.
Imagine having all of the information recorded on a stack of 1,540 CDs on a disk the size of a single CD. Or visualize having all of the information recorded on a stack of 154 CDs written on a one-inch square chip. New probe microscopy techniques and new organic materials could be combined in next generation data storage technology for unprecedented data density.
Twenty thousand hits per day --- that's the average dose of damage sustained by the genes within each cell of our body. How are innumerable mutations avoided? In a new study, researchers have proved the existence of a vital repair mechanism used by cells to correct this damage and showed that it's responsible for about 85% of what are termed "last-resort" repairs. Genes can be damaged by a variety of factors, such as ultraviolet light, cigarette smoke, or certain types of viruses. Such damage, if left unrepaired, can cause mutations, which can lead to disease. The "first resort" for genetic repair is most often a mechanism that works on an "all or nothing" basis: when unable to precisely correct the damage, it stops in its tracks, leading to what can be an even more harmful effect ? the death of the cell. Fortunately, nature has provided cells with two alternative, last-resort repair systems that can take command when the first rescue mechanism fails.
Atmospheric particles that become acidic through exposure to such pollutants as sulfuric acid can lead to vast increases in the formation of secondary organic aerosols, a new study indicates. Such aerosols are major components of the unsightly haze that hangs over cities and oil refineries and even affects otherwise pristine U.S. national parks.
A new study by the U.S. Geological Survey (USGS) shows that the Castle Mountain fault in south-central Alaska may be ready to produce a strong magnitude 6 to 7 earthquake. Peter Haeussler, the principal investigator in the study, said his research demonstrated that major earthquakes occurred on this fault on average every 700 years or so in the last 2,700 years, and that the last significant earthquake along the fault occurred about 650 years ago. The Castle Mountain fault is the only active fault that comes to the earth's surface in the Anchorage region, and the eastern part of the fault produced light to moderate magnitude 5.7 and 4.6 earthquakes in 1983 and 1996.
Researchers in Los Angeles have localized a region on chromosome 16 that is likely to contain a risk gene for Attention Deficit Hyperactivity Disorder, the most prevalent childhood-onset psychiatric disorder. The scientists say their finding suggest that the suspected risk gene may contribute as much as 30 percent of the underlying genetic cause of ADHD and may also be involved in a separate childhood onset disorder, autism.
In case there was any doubt, researchers in --- where else? --- Los Angeles have determined that living near a freeway exposes you to a lot more pollution than if you lived further away. Specifically, a UCLA team found people who live, work or travel within 165 feet downwind of a major freeway or busy intersection are exposed to potentially hazardous particle concentrations up to 30 times greater than normal background levels.
For the latter part of the 20th century, much of what we knew about plasma fusion came out of Princeton's Plasma Physics Laboratory. There the massive Tokamak Fusion Test Reactor worked for 15 years, forcing hydrogen atoms together in crazy strong magnetic fields in the search for a sustainable fusion reaction. I wrote a paper about this back in the late 1980s in UC Santa Barbara's terrific History of the Nuclear Age. Anyhow, the Tokamak was taken offline in 1997, and Princeton says it has now successfully dismantled and removed the leviathan. Just to give you an idea about the machine's intensity, it was the first to produce more than 10 million watts of fusion power. And in 1995, TFTR attained a world-record temperature of 510 million degrees centigrade -- more than 25 times that at the center of the sun.
Incidentally, if you ever wondered what Tokamak means, it's not --- as I once thought --- some Native American name or word. It's actually Russian shorthand describing the squished donut shape of the magnets. To(roidal'naya) kam(era s) ak(sial'nym magnitnym polem), or toroidal chamber with axial magnetic field. Now you know.
Researchers have detailed the functioning of an enzyme that is a central component of a signaling pathway important for about 30 percent of cancers. The findings about how the enzyme, called farnesyl transferase (FTase), works could help improve the FTase-inhibiting drugs that pharmaceutical companies are now testing to fight a broad spectrum of cancers.
FROM THE TRENCHES: A consortium of scientists announced that it has deciphered the genetic code of the parasite that causes the deadliest form of Malaria, an illness that kills more than a million people a year in developing nations.
