professor of biology

Breakthrough model for human cancer may improve development of cancer drugs; study in PNAS

CAMBRIDGE, Mass., April 6, 2009 - AVEO Pharmaceuticals, Inc., a biopharmaceutical company leveraging breakthrough discoveries in cancer biology to discover, develop and commercialize targeted oncology therapies, today announced findings from its novel human-in-mouse (HIM) cancer model system, in which AVEO successfully created invasive human tumors from primary human breast tissue that develop

Reversing ecology reveals ancient environments

From hair color to the ancestral line of parasitic bacteria, scientists can glean a lot from genes. But imagine if genes also revealed where you lived or who you spent time with. It turns out they do, if you know where and how to look.

Climate change: Faster than we ever thought

Without decisive action, global warming in the 21st century is likely to accelerate at a much faster pace and cause more environmental damage than predicted, according to a leading member of the Nobel Prize-winning Intergovernmental Panel on Climate Change.

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Biodiversity feeds on itself

Biodiversity feeds on itself, researchers found, as evolving animals open niches for other new species. Such is the case, says a Michigan State University researcher, with a parasite found to be evolving in sequence with an emerging host insect in western Michigan apple trees.

U.S. lizards adapting to dodge fire ant attacks

Native fence lizards in the southeastern United States are adapting to potentially fatal invasive fire-ant attacks by developing behaviors that enable them to escape from the ants, as well as by developing longer hind legs, which can increase the effectiveness of this behavior.

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Cell keeps spare set of DNA to ensure offspring gets fresh start

This is a little complex, but bear with us. Nearly all cells house their DNA inside a nucleus. But a little one-celled critter called Tetrahymena houses different versions of its DNA in each of its two nuclei. Researchers have found that the smaller nucleus (called the micronucleus) just keeps the cell's full genome safe, acting as a sort of "lock box." The larger nucleus (called the macronucleus) uses the DNA to regulate the cell's life functions. When the cell mates to create a new generation, the two work together to compare the cell's current DNA against what's been stored in the lock box. If any foreign genes have snuck in (like from a virus) they nuclei eliminate it, to make sure baby gets a fresh start. Pretty neat, with possible implications for larger organisms, too.

And then there were three

I just don't get those guys anymore.... (Photo by Lori Eggert, UCSD) You learn a lot analyzing dung. Sampling specimens from wild African elephants, UC San Diego researchers have found the continent is home to three distinct types of Proboscidia, not two. Apparently the distinction in the past was between savanna and forest elephants. Now it turns out a third, genetically distinct species has evolved that swings both ways.

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