Archive | May, 2010

Chances of surviving cardiac arrest depends on your neighborhood

The odds of surviving cardiac arrest may depend on which part of town you call home and whether anyone in the neighborhood comes to your rescue by attempting to perform cardiopulmonary resuscitation (CPR), according to a first-of-its-kind study in the June issue of the Annals of Internal Medicine.

The study found that certain neighborhoods in Fulton County, Ga.─which includes Atlanta─have an incidence of cardiac arrest two to three times higher than other parts of the county and fewer bystanders who attempt to perform CPR. Surprisingly, these findings remained across time, meaning that, year after year, residents of these neighborhoods were at the highest risk for a cardiac arrest event, and had the lowest rates of bystander CPR in Fulton County. These neighborhoods tend to have lower median household incomes, more Black residents, and lower education levels.

“These findings have national public health indications. They show that it is time to change our thinking on how and where we conduct CPR training if we are ever going to change the dismal rate of survival from cardiac arrest,” said Comilla Sasson, M.D., M.S., lead author of, “Small Area Variations in Out-of-Hospital Cardiac Arrest: Does the Neighborhood Matter?” who conducted the study as a Robert Wood Johnson Foundation Clinical Scholar at the University of Michigan. “Nine out of 10 people die from a cardiac arrest event. This number can and must change.”

In Fulton County, if rates of CPR performed by bystanders were improved to the level achieved by the highest performing parts of the county, an additional 355 people could receive CPR. This could save an additional 15 lives each year in Fulton County alone.

CPR training often targets young, healthy volunteers who are least likely to encounter an individual in cardiac arrest. However, using Sasson’s method, a public health surveillance registry based on that of the CDC can be used to design targeted interventions in the neighborhoods that need CPR training the most. Boosting bystander CPR rates in the United States from the current average of 27 percent to 56 percent could save an additional 1,500 lives per year.

Each year, in the United States, nearly 300,000 patients experience cardiac arrest — the sudden, abrupt loss of heart function — while outside of the hospital. Heart disease is the most common cause of cardiac arrest, but other factors such as drowning, choking, electrocution and trauma can cause cardiac arrest.

An earlier study by Sasson in the 2009 journal Circulation found that the nation’s survival rate for out-of-hospital cardiac arrest has been at a standstill at 7.6 percent for nearly 30 years. Because most incidences of cardiac arrest occur outside a hospital and are often witnessed by bystanders, efforts to improve survival should focus on the prompt delivery of medical interventions such as the delivery of CPR.

“To improve cardiac survival rates that have been stagnant for 30 years, CPR training should be more basic and available to the people who are most likely to witness someone experiencing cardiac arrest,” Sasson said. “Health care resources are extremely limited. To make improvements, we need to understand where and how best to make change.”

For this study in the Annals of Internal Medicine, researchers analyzed emergency medical services (EMS) and 911 call data from the Cardiac Arrest Registry to Enhance Survival Rates (CARES), which was used to identify areas with higher incidences of cardiac arrest and low rates of bystander CPR. CARES is an EMS Web-based registry for out-of-hospital cardiac arrests. Census information was used to approximate neighborhoods. The study is believed to be the first to show relative stability in the incidence of cardiac arrest within census tracts from year to year.

Sasson is preparing to take action to improve cardiac survival with education and outreach efforts in the 30 U.S. cities that constitute the CARES Study Group. They are spread across the United States and include cities such as: Anchorage, Alaska; Austin, Texas; Boston, Mass.; Columbus, Ohio; Denver, Colo.; Honolulu, Hawaii; Houston, Texas; San Diego, Calif.; Sioux Falls, Idaho; and Wake County, N.C.

A practicing emergency physician, Sasson became interested in identifying communities with higher incidences of cardiac arrest, while working at Grady Memorial Hospital in Atlanta. There, she noticed that cardiac arrest patients from certain parts of Fulton County often arrived at the hospital already dead, while cardiac arrest patients from other parts of Fulton County arrived at the hospital alive and went on to make full recoveries.

Robert Wood Johnson Clinical Scholars® has fostered the development of physicians who are leading the transformation of health care in the United States through positions in academic medicine, public health and other leadership roles for three decades. Through this program, future leaders learn to conduct innovative research and to work with communities, organizations, practitioners and policy-makers on issues important to the health and well-being of all Americans. For more information, visit www.rwjcsp.unc.edu.

For more information on the University of Michigan Health System, please visit www.med.umich.edu.

The research findings presented here are those of the researcher and are not necessarily the views of the Robert Wood Johnson Foundation.

Contact:

Susan Lamontagne,
IQ Solutions,
631-899-3825,
slamontagne@iqsolutions.com

Shantell Kirkendoll,
University of Michigan,
732-764-2220,
smkirk@umich.edu

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Impulsivity-related problem drinking decreases greatly for 18- to 25-year-olds

  • Impulsivity normally decreases during emerging and young adulthood and is associated with reduced substance abuse.
  • Not all individuals, however, “mature out” of impulsive behavior.
  • A new study has found that 18-to-25-year olds exhibited the largest declines in impulsivity as well as the sharpest decreases in alcohol consumption.

Personality traits associated with impulsivity normally decrease during emerging and young adulthood, and these decreases are associated with reduced substance use. A new study of “trajectories” of impulsivity and their association with problem alcohol use has found that the 18-to-25-years-of-age group exhibited the largest declines in impulsivity as well as the sharpest decreases in alcohol consumption.

Results will be published in the August 2010 issue of Alcoholism: Clinical & Experimental Research and are currently available at Early View.

“Traits related to impulsivity, such as undirectedness or ‘reverse-scored conscientiousness,’ tend to normally decrease from late adolescence into early adulthood, approximately from ages 18 to 35,” explained Andrew K. Littlefield, a doctoral student in clinical psychology at the University of Missouri and corresponding author for the study.

“This study is unique in examining patterns of impulsive traits across time,” added Danielle Dick, assistant professor of psychiatry, psychology, and human and molecular genetics at Virginia Commonwealth University. “It is interesting that the trajectories of impulsivity identified here parallel previous work on trajectories of externalizing behavior — namely, that there is a class of individuals who appear to ‘mature out’ of impulsive behavior with emerging adulthood, while others do not show this normative maturing out.”

“We used a person-centered trajectory approach in order to characterize individual differences in age-related changes in impulsivity,” said Littlefield. “This approach allowed us to empirically discover groups of individuals that showed similar stability and change in impulsivity from ages 18 to35.”

Littlefield and his colleagues used data drawn from a longitudinal study of individuals at risk for alcohol dependence (AD) because of a family history of alcoholism. Analyses were based on data collected from 489 college students (266 females, 223 males; 51% with a family history of AD) who were first assessed as freshmen at a large, public university and were then assessed six more times during the next 15 years. Initial analyses identified five trajectory groups that differed in baseline levels of impulsivity and developmental patterns of change.

“Our longitudinal trajectory analyses suggested key differences in both initial levels and change in impulsivity from ages 18 to 35,” said Littlefield. “Of most importance, our findings suggest that individuals that made the steepest decreases in impulsivity also made the sharpest decreases in alcohol use and alcohol-related problems from ages 18 to 25.” The major correlates were alcohol use — typically quantity frequency and a heavy drinking measures — and alcohol problems.

Littlefield said that through identification of distinct trajectory groups, researchers can better understand how different changes in individuals’ impulsivity relate to alcohol use and related problems.

“Many researchers and clinicians think of personality as an incredibly stable construct that does not change across time, however, these findings provide clear evidence that at least some individuals undergo significant changes in impulsivity across time,” he said. “Future studies could examine why some individuals make significant changes in impulsivity across time whereas other individuals’ level of impulsivity remains relatively stable. Identifying factors that enhance or inhibit seemingly beneficial changes in personality may inform treatment approaches that could facilitate decreased impulsivity.”

Alcoholism: Clinical & Experimental Research (ACER) is the official journal of the Research Society on Alcoholism and the International Society for Biomedical Research on Alcoholism. Co-authors of the ACER paper, “Developmental Trajectories of Impulsivity and Their Associations with Alcohol Use and Related Outcomes during Emerging and Young Adulthood I,” were Kenneth J. Sher and Douglas Steinley of the University of Missouri-Columbia and the Midwest Alcoholism Research Center. The study was funded by the National Institute on Alcohol Abuse and Alcoholism. This release is supported by the Addiction Technology Transfer Center Network at http://www.ATTCnetwork.org.

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Newly discovered kinase regulates cytoskeleton, and perhaps holds key to how cancer cells spread

Scientists at the University of California, San Diego have identified a previously unknown kinase that regulates cell proliferation, shape and migration, and may play a major role in the progression or metastasis of cancer cells.

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The crime of mental illness

Canada needs to change its approach to mentally ill prisoners as correctional facilities worldwide contain a higher percentage of people with mental illness than the general population, states an editorial (pre-embargo link only) http://www.cmaj.ca/embargo/cmaj100405.pdf in CMAJ (Canadian Medical Association Journal) .

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Faulty gene stops cell ‘antennae’ from transmitting

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Acupuncture’s molecular effects pinned down

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Research finds surgery outperforms drug therapy in treatment of benign prostatic hyperplasia

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Study finds reforestation may lower the climate change mitigation potential of forests

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Circulating tumor cells correlate with poorer survival in pancreatic cancer patients

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Revealing the ancient Chinese secret of sticky rice mortar

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Canadian research examines effects of scientific claims on oil

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University of Nevada, Reno, video game research project to help blind children exercise

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Age is a factor in choosing between two comparable stroke-prevention procedures

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UCLA biologists report how whales have changed over 35 million years

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Prenatal exposure to BPA and DES may increase breast cancer risk

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Montana State develops new antenna to aid rural emergency workers

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New bacterial signaling molecule could lead to improved vaccines

Many disease-causing microbes carry pumps that expel antibiotics, making the bugs hard to kill with standard drugs. Ironically, these same [...]

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UCSF analyses detail tobacco industry influence on health policy

Three new UCSF studies describe the wide reach of the tobacco industry and its influence on young people, military veterans [...]

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