amyotrophic lateral sclerosis als
Malfunctioning gene associated with Lou Gehrig’s disease leads to nerve-cell death in mice
PHILADELPHIA — Lou Gehrig’s disease, or amyotrophic lateral sclerosis (ALS), and frontotemporal lobar degeneration (FTLD) are characterized by protein clumps in brain and spinal-cord cells that include an RNA-binding protein called TDP-43. This …
Misbehaving molecules in ALS
A new study reveals for the first time how gene mutations lead to the inherited form of amyotrophic lateral sclerosis (ALS), or Lou Gehrig’s disease. The study suggests that the two most prominent theories of how familial ALS (FALS) and other related diseases develop are both right in part.
Researchers Combine Dietary Supplement, Antibiotic to Treat Lou Gehrig's disease
A new study shows that combining the supplement creatine and the antibiotic minocycline significantly slows disease progression and prolongs survival in a mouse model of amyotrophic lateral sclerosis (ALS), or Lou Gehrig’s disease. The combined treatment was significantly more effective than either compound administered alone. Both creatine and minocycline have previously been shown to improve outcomes in a mouse model of this disabling neurological disease, but this study is the first to test a combination of the two.