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Researchers have uncovered evidence that major evolutionary changes are more likely to occur in approximately 400 ‘fragile’ genomic regions that account for only 5 percent of the human genome. The findings, reported in the June 24 issue of the Proceedings of the National Academy of Sciences (PNAS), undercut the widely held view among scientists that evolutionary breakpoints ? disruptions in the order of genes on chromosomes ? are purely random. Apart from its implications for evolutionary theory, the study could have major implications for medical research related to diseases such as leukemia, which are caused by clinical (rather than evolutionary) chromosomal breakpoints.

Biologists at the University of California, San Diego have determined that a protein essential for the normal embryonic development of fruit flies is also used by mammals to assist in the timely healing of cuts and lacerations. Their discovery, detailed in the June 3 issue of the journal Developmental Cell, provides new insight for scientists into the molecular mechanisms responsible for wound healing in humans and may one day lead to the design of new drugs for individuals whose healing is compromised.

Men are from Mars and women are from Venus, or so we’ve been told, and when it comes to jealousy this is especially true. Men, psychologists have long contended, tend to care more about sexual infidelity while women usually react more strongly to emotional infidelity. This view has long been espoused by evolutionary psychologists who attribute these gender differences to natural selection, which, they say, encouraged the sexes to develop different emotional reactions to jealousy. However, a recent research paper published in Personality and Social Psychology Review by Christine Harris, a psychologist with the Center for Brain and Cognition at the University of California, San Diego, casts serious doubts on this view of gender differences on jealousy and argues that more men and women appear to view sexual and emotional jealousy in the same light.

Researchers have for the first time described a method that Staphylococcus aureus (staph) infection uses to inactivate the body’s immune system. A protein produced by the staph bacteria causes previously healthy B cells — a specialized cell of the immune system — to commit suicide, a process called apoptosis. “By the targeted elimination of disease-causing B cells, properly dosed injections of SpA may have the potential to control the over-activity of the immune system that causes damage in autoimmune diseases like lupus and in certain cancers,” said Gregg Silverman, M.D., UCSD professor of medicine and senior author of the paper.

Two versions of an oral drug that halts the deadly action of smallpox and related orthopox viruses have been shown by researchers in Alabama and California to be effective in cowpox-infected mice, whether given three to five days before or two to three days after infection. The study evaluated the dosage regimen and effectiveness of four different ether lipid analogs of cidofovir (CDV), a compound that blocks the activity of variola, the virus that causes smallpox, cowpox, vaccinia and other orthopox viruses. Shown most effective in treating lethal cowpox infection in mice were hexadecyloxypropyl-CDV (HDP-CDV) and octadecyloxyethyl-CDV (ODE-CDV). In addition, the study pinpointed the time period for effectiveness when the drug is administered prior to or after infection.

Biologists at the University of California, San Diego have discovered that Bacillus thuringiensis, or Bt — a bacterium that produces natural protein insecticides that have been used by organic farmers for five decades — can also produce similar natural proteins that kill nematodes. The discovery could pave the way for the development of an inexpensive and environmentally safe means of controlling the parasitic roundworms that each year destroy billions of dollars in crops, cause debilitating diseases in farm animals and pets, and now infect a quarter of the world’s human population.

America is facing a major roadblock to medical progress. For the speedy translation of promising scientific discoveries into patient treatment, we need a special breed of medical researchers who are trained to ask clinically relevant questions in a health research environment. It’s these individuals who transform clinical observations into research studies and eventual medical advances.

Although the oceans cover 70 percent of the planet’s surface, much of their biomedical potential has gone largely unexplored. Until now. A group of researchers at Scripps Institution of Oceanography at the University of California, San Diego, have for the first time shown that sediments in the deep ocean are a significant biomedical resource for microbes that produce antibiotic molecules. In a series of two papers, a group led by William Fenical, director of the Center for Marine Biotechnology and Biomedicine (CMBB) at Scripps Institution, has reported the discovery of a novel group of bacteria found to produce molecules with potential in the treatment of infectious diseases and cancer.

Researchers have determined the molecular machinery that triggers normal cardiac muscle growth and survival, and have linked defects in this complex to an inherited form of human cardiomyopathy, a type of heart failure where an enlarged heart loses its ability to pump blood. Published in the December 27, 2002 issue of the journal Cell, the study also identifies a subset of German cardiomyopathy patients with a specific gene mutation that disrupts the heart muscle’s normal stretch activity. This mutation has apparently been passed down through several generations of Northern Europeans.

Female coronary bypass surgery patients whose husbands viewed an optimistic informational videotape prior to their surgery experienced fewer complications than did women whose husbands received only the standard hospital preparation. The study evaluated the progress of 226 male and 70 female patients for six months after their first coronary artery bypass graft (CABG) surgery. Prior to the patients’ discharge from the hospital, the spouses of the patients viewed one of two videotapes — one more optimistic, than the other– informing them of what to expect during the recovery period.

The culmination of hundreds of research dives, scientific analysis, and high-tech mapping software has led to a fundamentally new approach for designing networks of marine reserves. An effort led by researchers at Scripps Institution of Oceanography at the University of California, San Diego, and reported in the Dec. 6 issue of Science, could become a powerful new method for decision makers charged with developing marine reserves and a forerunner for similar efforts around the world.

A full-body computed tomography (CT) scan may be beneficial to fewer people than previously thought, according to a study presented December 3, 2002 at the 88th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA) in Chicago. The results of a second study pointed out the need to establish guidelines and standardized reporting systems for this hotly debated diagnostic procedure.

An expert in computational biology at the University of California, San Diego (UCSD) estimates that it took many more evolutionary genome rearrangements than previously thought — both large and small — to account for differences in the human and mouse genomes. The findings are included in two landmark papers announced today.

A substantially higher death rate and inability to recover from kidney failure was documented in a study of 552 critically ill, hospitalized patients who were given diuretics, the most commonly used therapy for kidney failure. Published in the November 27, 2002 issue of the Journal of the American Medical Association (JAMA), the study suggests that physicians treating patients in acute kidney failure should reassess the use of diuretics, particularly when there is a limited response in terms of increased urine output.

Brain images from hundreds of people with schizophrenia at 10 research sites nationwide will be shared in a first-of-its-kind research project funded by the National Center for Research Resources (NCRR), a branch of the National Institutes of Health. The project will create an extensive database of brain information that it is hoped will expand understanding of disabling brain illnesses such as schizophrenia and speed the development of new treatments.

Until now, astronomers haven’t been able to offer a full explanation for why the Milky Way and other galaxies produce new stars at a relative snail’s pace. While they have known for decades that high turbulence keeps huge clouds of hydrogen gas from condensing into stars, they haven’t identified all the causes of the galactic perturbations. In a coming report researchers in San Diego say they have discovered that a well-known, but overlooked source of heating?regular outbursts of ultraviolet radiation from clusters of very large, bright stars?may play a significant role in keeping the Milky Way’s gas continually stirred up.

Cancer researchers in San Diego have developed a 3-step process in which human leukemia cells and neighboring immune-system T cells are manipulated together in the laboratory to create a powerful and specific cancer-killing cocktail. “For reasons that are not yet entirely clear, leukemia cells fail to trigger immune responses,” said the study’s senior author, Edward D. Ball, M.D., of the Rebecca and John Moores UCSD Cancer Center. “We have developed a method in which we induce the leukemia cell to change its behavior and stimulate the immune system. At the same time, we persuade the immune system to wake up and attack only the leukemia cells.” The details of this approach, known as adoptive immunotherapy or cellular therapy, are reported in the October issue of the journal Biology of Blood and Marrow Transplantation.

High doses of the naturally occurring compound coenzyme Q10 has been found to slow by 44 percent the deterioration in function that occurs in Parkinson’s disease. The greatest benefit was seen in everyday activities like eating, dressing, bathing and walking. But researchers say that before people run out to RightAid for a barrel of the stuff, a wider study is needed (this one tracked 80 patients). Parkinson?s is a degenerative disorder of the brain in which patients develop tremor, slowness of movement and stiffness of muscles. It affects about 1 percent of Americans over the age of 65.

See also: Parkinson’s patients look to gene therapy