A protein known to exist in the brain for more than 30 years, called 5-lipoxygenase, has been found to play a regulatory role in the formation of the amyloid beta in the brain, the major component of plaques implicated in the development of Alzheime…
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For centuries, doctors have tried to find effective ways to treat chronic pain, a devastating neurological disorder that affects almost 90 million Americans. A new study shows that two proteins in the brain trigger the neuronal changes that amplify and sustain this type of pain. The finding may lead to new ways of treating chronic pain. “This is the first [chronic pain] study to show clear molecular targets in the brain,” says Min Zhuo, Ph.D., of Washington University in St. Louis, Missouri, senior author of the report. “Drugs that inhibit these two proteins may help to reduce chronic pain.”
Researchers have discovered a communication link between proteins in the brain that could lead to improved treatments for psychiatric disorders and stroke. The discovery could create the possibility that new antipsychotic medication could be designed to modify the interaction related to cell-to-cell communication to prevent abnormal activity and cell death.