New findings on how tuberculosis (TB) bacteria develop multi-drug tolerance point to ways TB infections might be cured more quickly.
The study will be published April 1 in the journal Cell. The results identify both a mechanism and a potenti…
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New findings on drug tolerance in TB suggest ideas for shorter cures
Key difference in how TB bacteria degrade doomed proteins
UPTON, NY — Scientists at the U.S. Department of Energy’s (DOE) Brookhaven National Laboratory and Stony Brook University have discovered a key difference in the way human cells and Mycobacterium tuberculosis bacteria, which cause TB, deliver unw…
Sloppy repair helps TB bug resist drugs
Shoddy work by a DNA-repair enzyme allows tuberculosis-causing bacteria to develop antibiotic resistance, scientists at the National Institute of Allergy and Infectious Diseases (NIAID) have discovered. Reported in the current issue of the journal Cell, the finding could lead to new ways to treat TB without risking the development of drug resistance.
Study first to show how tuberculosis moves through the body
A University of Washington study is the first to provide visualizations of tuberculosis infections in an intact living organism and reveals how tuberculous granulomas, the tight aggregates of macrophages that are the hallmarks of this infection, are formed within infected organisms (Macrophages are a specialized class of white blood cells that patrol tissues and ingest foreign particles, such as bacteria and viruses, as well as dead and dying cells. Macrophages provide the backbone of the immune system.)