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ucla research

Antioxidants May Fight Blood Vessel Blockage, Heart Disease

A UCLA research team has discovered that a popular health supplement and antioxidant vitamins may help prevent atherosclerosis, or blockage of the blood vessels. The findings are reported in the Jan. 13 online edition of the Proceedings of the National Academy of Sciences. “Our findings suggest that people who take dietary supplements of L-arginine, an amino acid, and antioxidants, such as vitamins C and E, might be at a lower risk for atherosclerosis and heart disease,” said Dr. Louis J. Ignarro, a 1998 Nobel laureate in medicine and UCLA professor of molecular and medical pharmacology. “This is significant because cardiovascular disease is still the No. 1 cause of death in the United States.”

Hormone Therapy Associated With Increased Breast Density

A new study suggests that the use of combination hormone therapy is associated with a modest increase in breast density, which is a known risk factor for breast cancer. The findings appear in the Jan. 1 issue of the Journal of the National Cancer Institute. The degree of breast-cancer risk that is associated with breast density is greater than that associated with almost all other known breast-cancer risk factors. A previous analysis of data from the Postmenopausal Estrogen/Progestin Interventions (PEPI) Trial, a randomized trial looking at the effects of postmenopausal hormone therapy (estrogen alone or estrogen plus three different progestin regimens) on breast density, showed that some women who used combination estrogen/progestin therapy experienced an increase in breast density. However, the analysis did not look at the magnitude of that increase.