How predictable are new chemical reactions that have never been done before?

I’m curious about how far chemistry has evolved along with Physics.. I am currently reading a book on Physics, and will move to chemistry next. But what has piqued my curiosity for now is.. How predictable is chemistry? If you are going to make various chemicals mixing and matching different elements of the periodic chart for the first time ever, how easy is it to predict the potential outcome? What tells you what solids and liquids will change states and what the properties of your new mixture will be? Does the current list of particles that are smaller than electrons, protons, and nuetrons help figure this stuff out or make it make even more sense if you were already able to figure it out with electrons, protons or nuetrons?


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