The cause of higher incidence of gallstone after radical gastrectomy still remains unknown. Almost all previous studies have attributed gallstone formation to gallbladder motility disorder after gastrectomy, But this theory cannot completely explain it. Is there any other risk factor of gallstone formation after gastrectomy?
A research article to be published on May 28, 2010 in the World Journal of Gastroenterology addresses this question. The research team led by Professor Niu from Zhongshan Hospital of Fudan University enrolled 206 patients between January 2005 and December 2006, who underwent radical gastrectomy for gastric cancer. These patients were grouped according to XbaI polymorphisms of APOB gene. After at least 2 years follow up, they found that the incidence of gallstone following gastrectomy was significiantly higher in patients with the X+ allele of APOB gene, who have a higher concentration of TC and LDL. These results demonstrate that the X+ allele may influence the levels of TC and LDL, resulting in an increased saturation of bile cholesterol, leading to the gallstone formation after gastrectomy. The authors believe besides the gallbladder motility disorder, X+ allele of APOB gene is another important risk factor of gallstone formation after gastrectomy.
Liu FL, Lu WB, Niu WX. XbaⅠ polymorphisms of apolipoprotein B gene: Another risk factor of gallstone formation after radical gastrectomy. World J Gastroenterol 2010; 16(20): 2549-2553 http://www.wjgnet.com/1007-9327/full/v16/i20/2549.htm
Correspondence to: Dr. Wei-Xin Niu, MD, Department of General Surgery, Zhongshan Hospital, Fudan University, #180 Fenglin Road, Shanghai 200032,
Telephone: +86-21-64041990 Fax: +86-21-64037224
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World Journal of Gastroenterology (WJG), a leading international journal in gastroenterology and hepatology, has established a reputation for publishing first class research on esophageal cancer, gastric cancer, liver cancer, viral hepatitis, colorectal cancer, and H pylori infection and provides a forum for both clinicians and scientists. WJG has been indexed and abstracted in Current Contents/Clinical Medicine, Science Citation Index Expanded (also known as SciSearch) and Journal Citation Reports/Science Edition, Index Medicus, MEDLINE and PubMed, Chemical Abstracts, EMBASE/Excerpta Medica, Abstracts Journals, Nature Clinical Practice Gastroenterology and Hepatology, CAB Abstracts and Global Health. ISI JCR 2008 IF: 2.081. WJG is a weekly journal published by WJG Press. The publication dates are the 7th, 14th, 21st, and 28th day of every month. WJG is supported by The National Natural Science Foundation of China, No. 30224801 and No. 30424812, and was founded with the name of China National Journal of New Gastroenterology on October 1, 1995, and renamed WJG on January 25, 1998.
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