Nitrate improves mitochondrial function

The spinach-eating cartoon character Popeye has much to teach us, new research from the Swedish medical university Karolinska Institutet shows. The muscles’ cellular power plants — the mitochondria — are boosted by nitrate, a substance found in abundance in vegetables such as lettuce, spinach and beetroot.

For half a century, inorganic nitrate has been associated with negative health effects, but more recently, evidence of the contrary has mounted. In the 1990s, a research group at Karolinska Institutet demonstrated how the body can convert nitrate to NO, a molecule involved in many important bodily functions, such as blood pressure regulation, the immune defence and cell metabolism.

In this new study, the same team had healthy people take nitrate equivalent to 200-300g of spinach or lettuce for three days, after which they were given a cycling task to perform. The researchers then analysed samples from their thigh muscles and compared them with similar samples from the same subjects when they had taken a placebo instead. After nitrate ingestion, a significant improvement was seen in the efficiency of the mitochondria, which consumed less oxygen and produced more of the energy-rich substance ATP per consumed oxygen molecule.

“The mitochondria play a key role in cellular metabolism,” says Professor Eddie Weitzberg, who is heading the study with Professor Jon Lundberg. “Improved mitochondrial function probably has many positive effects on the body, and could explain some of the health benefits of vegetables.”

The results, which are published in Cell Metabolism, are of sports-physiological interest, as they show that nitrate reduces oxygen consumption during physical exercise; however, they are also of potential significance to diseases involving mitochondrial dysfunction, such as diabetes and cardiovascular disease.

The group has also recently shown that nitrate reduces the blood pressure of healthy individuals and that in laboratory animals it counteracts components of the metabolic syndrome, a pre-stage of diabetes. Other scientists have demonstrated protective effects of nitrate and nitrite in animal models against heart attack and stroke.

Publication: ‘Dietary inorganic nitrate improves mitochondrial efficiency in humans’, Filip J Larsen, Tomas A Schiffer, Sara Borniquel, Kent Sahlin, Björn Ekblom, Jon O Lundberg & Eddie Weitzberg, Cell Metabolism, 2 February 2011.

For further information, please contact:

Eddie Weitzberg, Professor

Department of Physiology and Pharmacology

Office: +46 (0)8-517 748 92 or +46 (0)703-217994

Email: [email protected]

Web: http://ki.se/ki/jsp/polopoly.jsp?l=en&d=1982

Katarina Sternudd, Press Officer

Tel: +46 (0)8-524 838 95

Email: [email protected]

Download photo: ki.se/pressroom

Karolinska Institutet is one of the world’s leading medical universities. Its mission is to contribute to the improvement of human health through research and education. Karolinska Institutet accounts for over 40 per cent of the medical academic research conducted in Sweden, and offers the country’s broadest range of education in medicine and health sciences. Since 1901 the Nobel Assembly at Karolinska Institutet has selected the Nobel laureates in Physiology or Medicine. More information on ki.se.


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