“The human body has many types of stem cells that have the potential to regenerate other organs,” said Dr. Ito. “The methods behind communication between stem cells of hair and color during hair replacement may give us important clues to regenerate complex organs containing many different types of cells.”
Using genetic mouse models, researchers were able to examine how Wnt signaling pathways enabled both hair follicle stem cells and melanocyte stem cells to work together to generate hair growth and produce hair color. Research also showed the depletion (or inhibition or abnormal) Wnt signaling in hair follicle stem cells not only inhibits hair re-growth but also prevents melanocytes stem cell activation required for producing hair color. The lack of Wnt activation in melanocyte stem cells leads to depigmented or gray hair.
The study raises the possibility that Wnt signaling is a key pathway for the regulation of melanocyte stem cells and shows how melanocyte behavior is associated with hair regeneration. This insight provides further understanding of diseases in which melanocytes are either appropriately lost such as hair graying or undergo uncontrolled cell growth as in melanoma.
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