This is essential information that can be used as the technology moves its way toward widespread release, Dogariu says.

“We developed a model that has been essentially confirmed by the experimental results that we have collected,” he says. “We had the measurements that appear to be quite sensitive to real transformations in the bloodstream, but now we can put numbers to those changes.”

The work allows the researchers to, for the first time, relate their measurements to what was actually happening to the blood and explain the changes in the way that red blood cells “jiggle” around in the blood stream.

“This is what we consider to be the next level in the development of this concept,” Dogariu says.

The researchers’ next clinical trial will take place with pediatric patients, and then they hope to move into a series of clinical trials with adults. With continued success and funding, the researchers hope to see the blood monitor become available within the next five to seven years.

Study co-authors also included Jose Rafael Guzman-Sepulveda, a graduate of UCF’s College of Optics and Photonics doctoral program and now a researcher with the Center for Research and Advanced Studies of the National Polytechnic Institute in Mexico; and Mahed Batarseh and Ruitao Wu, graduate research assistants in UCF’s College of Optics and Photonics.

The research was funded by the U.S. National Institutes of Health.

Dogariu received his doctoral degree in engineering from Hokkaido University in Sapporo, Hokkaido, Japan, and joined UCF in 1997.

DeCampli received his doctoral degree in astrophysics from Harvard University and his doctor of medicine degree from the University of Miami. He completed residency in cardiac surgery at Stanford University and joined UCF’s College of Medicine in 2009.