Wang, C et al 2005: Cyclin D1 Antagonizes BRCA1 Repression of Estrogen Receptor alpha Activity

Cyclin D1 is overexpressed in half of breast cancer cases. This research indicates that BRCA1 suppresses Cyclin D1 activation of ERa, an estrogen sensitive receptor. In breast cancer, BRCA1 is inactivated and Cyclin D1 is free to upregulate ERa. Therefore, Cyclin D1 is a great drug target.

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