Life & Non-humans

Study shows preschool can prevent abuse

In one of Chicago’s poorest neighborhoods, a little girl with pigtails and a denim jumper stands in front of a table and fingers the shape of wooden letters as she fits them into a puzzle. In the next room, her mother talks to a parent-resource teacher about taking the GED and how she can help her daughter with homework. According to a new study by researchers at the University of Wisconsin-Madison, this type of learning environment does more than strengthen skills – it helps cut the rate at which enrolled children will be abused or neglected by their parents or caregivers. The findings, published in the current issue of the journal Child Development, provide new evidence that preschool programs can impact not just school readiness, but long-term family outcomes.

Cancer squeezes through the gaps

Cancer cells move around the body (become metastatic) by chopping up the dense matrix that surrounds them. But drugs that prevent the chopping have been disappointing in animal and human anti-cancer trials. Now researchers provide an explanation for this failure: the drug-treated cells revert to a primordial, ameboid form of cell movement that allows them to squeeze through gaps in the matrix.

Researchers achieve germline transmission of ‘gene knockdown’ in mice

RNA interference (RNAi) has emerged as an extremely versatile and powerful tool in biomedical research. A new study published in the February issue of Nature Structural Biology reports the creation of transgenic mice in which inherited RNAi lowers or silences the expression of a target gene, producing a stable “gene knockdown.” This finding extends the power of RNAi to genetic studies in live animals, and has far-reaching implications for the study and treatment of many human diseases.

Scientists Discover Rich Medical Drug Resource in Deep Ocean Sediments

Although the oceans cover 70 percent of the planet’s surface, much of their biomedical potential has gone largely unexplored. Until now. A group of researchers at Scripps Institution of Oceanography at the University of California, San Diego, have for the first time shown that sediments in the deep ocean are a significant biomedical resource for microbes that produce antibiotic molecules. In a series of two papers, a group led by William Fenical, director of the Center for Marine Biotechnology and Biomedicine (CMBB) at Scripps Institution, has reported the discovery of a novel group of bacteria found to produce molecules with potential in the treatment of infectious diseases and cancer.

New study suggests missing link that explains how dinosaurs learned to fly

Two-legged dinosaurs may have used their forelimbs as wing-like structures to propel themselves rapidly up steep inclines long before they took to the skies, reports a University of Montana researcher in the January 17 issue of the journal Science. The new theory adds a middle step that may link two current and opposing explanations for how reptiles evolved into flying birds.

Researchers decipher cause of parasite’s worldwide spread

Research reveals that a unique combination of genes inherited less than 10,000 years ago allows the parasite responsible for toxoplasmosis to infect virtually all warm-blooded animals. Parasite life cycles are complex and thought to develop over long periods with their hosts. This study reveals that parasites sometimes adapt rapidly to new hosts, indicating that host-parasite relationships may not always represent stable, long-term associations.

Early mammals used pelvic bones to trot, study finds

Scientists studying the earliest mammals have been stumped for centuries about the function of two pelvic bones found in the fossil record that most mammals don’t have today. A study published in this week’s issue of the journal Science suggests those bones were involved in locomotion and helped the animals become more mobile, a find that could help researchers pinpoint a key moment in the evolution of mammals.

Umbilical cord matrix, a rich new stem cell source, study shows

The cushioning material or matrix within the umbilical cord known as Wharton’s jelly is a rich and readily available source of primitive stem cells, according to findings by a research team at Kansas State University. Animal and human umbilical cord matrix cells exhibit the tell-tale characteristics of all stem cells, the capacity to self-renew and to differentiate into multiple cell types. The cells — called cord matrix stem cells to distinguish them from cord blood cells — can be obtained in a non-invasive manner from an abundant source of tissue that is typically discarded.

Researchers Decipher Cause of Parasite’s Worldwide Spread

Research at Washington University School of Medicine in St. Louis reveals that a unique combination of genes inherited less than 10,000 years ago allows the parasite responsible for toxoplasmosis to infect virtually all warm-blooded animals. Parasite life cycles are complex and thought to develop over long periods with their hosts. This study reveals that parasites sometimes adapt rapidly to new hosts, indicating that host-parasite relationships may not always represent stable, long-term associations.

Growing Human Antibodies in Algae is Inexpensive, Fast

A group of scientists at The Scripps Research Institute have used algae to express an antibody that targets herpes virus, describing the work in an upcoming issue of the journal Proceedings of the National Academy of Sciences. This antibody could potentially be an ingredient in an anti-herpes topical cream or other anti- herpes treatments, but more importantly the algae expression technology that the TSRI team used could facilitate production of any number of human antibodies and other proteins on a massive scale.

Study Reconsiders Formation of Antarctic Ice Sheet

A new study posits an alternative theory regarding why Antarctica suddenly became glaciated 34 million years ago. The study challenges previous thinking about why the ice sheet formed and holds ramifications for the next several hundred years as greenhouse gases continue to rise. “Scientists have long known that Antarctica was not always covered in a sheet of ice. Rather, the continent was once highly vegetated and populated with dinosaurs, with perhaps just a few Alpine glaciers and small ice caps in the continental interior,” the study’s lead researcher said.

Rare Asian dolphin threatened by human activities

A rare dolphin species known for assisting fishermen by driving fish into their nets may soon disappear from the great Asian river for which the animals are named. According to a recent scientific survey by the Wildlife Conservation Society (WCS) and its partners, the Irrawaddy dolphin may vanish from the Ayeyarwady River (formerly Irrawaddy) without efforts to protect these aquatic mammals from human activities along the river.