Nintendo all grown up?

Japan’s Nintendo built its reputation on cheery games for children. But seeking a bigger chunk of the adult market, the purveyors of the Mario Bros. series and Pokemon are adding zombies, strippers and gunmen to the menu, the Wall Street Journal reports. It’s a shift in resources that carries some risk. The keep-it-clean approach has made Nintendo one of the few good guys in an industry criticized for violence, the Journal notes. And that has translated into big bucks. “In his 21-year life as a game character, Super Mario has grossed more money globally — $7 billion in software sales — than the combined take of Arnold Schwarzenegger and Mel Gibson at box offices around the world.” But times change. Fearing erosion in market share thanks to Sony and Microsoft, Nintendo over the next two months will spend $140 million to market videogames to American teens and 20-somethings, including promotions in nightclubs and tie-ins with brewer Heineken NV and others. New games will be edgier, sexier and more violent.

Parkinson’s patients look to gene therapy

Medical researchers have successfully reversed the progression of Parkinson’s disease in rats through the use of gene therapy. By adding a gene for a single enzyme, they were able to reprogram brain circuits and halt the deterioration of dopamine-producing brain cells, one of the key problems in the disease. The lack of dopamine is what leads the the tell-tale shaking and muscle twitches of Parkinson’s patients.

Hold on, my landfill’s ringing

By 2005, 130 million cell phones will be thrown out each year, according to a new study funded in part by the U.S. Environmental Protection Agency. Counting the phones, batteries and chargers, that comes to 65,000 tons a year, most of which will end up in landfills or being incinerated. And that has environmentalists freaked. “This is becoming a very serious problem, because the amount of cell phone waste is growing tremendously,” said Eric Most, a director at Inform, the group which issued the report. “These chemicals accumulate and persist in the environment. They get in the plants, soil, water, and then move up the stream to humans.” One approach to countering the increase that seems to have general support is a “take-back” program, in which phone manufacturers must agree to take-back old phones when consumers upgrade. Another plan sure to be DOA: Limiting waste by standardizing design elements so consumers have fewer reasons to buy new phones. “If we had had a government standard in the beginning,” one industry rep told the New York Times, “we’d still all be speaking on analog phones. And that means no e-mail, no text messaging, no Caller ID. Competition equals innovation in this case.”

Vlad the Impaler defeats Fritz the Ditz

Maybe Deep Fritz should be called On the Fritz. The German-built, chess-playing computer lost another game to 27-year-old Russian champ Vladimir Kramnik in a match billed as the “Brains of Bahrain.” The competition’s third day of play ended when Kramnik, well, kicked Fritz’ butt in 57 moves that showed DNA can still best silicon at some things. As reported by Reuters, Sunday’s game wasn’t completely one-sided. “Fritz, after early errors, fought back and startled Kramnik with some typical computer tactics. ‘I never imagined (the 27th move) and the tactics that followed. Only a computer would find and play something like that,’ Kramnik said later. ‘I was completely shocked.’ The Fritz team was more than a little embarrassed, however, when their brainchild in move 12 returned its bishop to its original square. This bizarre move was something even the lowliest human player would never consider.”

Do you see the key?

If a code is really good, it doesn’t matter much if the enemy (you know, them) gets ahold of one of your encrypted messages. What is risky, is letting your code key fall into the wrong hands. And their delivery is often the weak link in a communications network. “At the moment, highly secure encryption keys are typically sent by a man on a motorbike or a guy with a diplomatic bag,” notes one wonk. But researchers have devised a way to deliver keys using a beam of light, attaching data to individual photons as they stream from sender to receiver. The neat thing about that is if the light beam is intercepted and read, the state of the photons changes, alerting the recipient that the key has been compromised. Thursday British researchers said they’d reached a new milestone in the distance they can send encryption keys this way: 14 miles. It doesn’t sound like much, but it sure beats the few feet the technique could muster just a couple years ago. Expect earth-to-satellite distances soon.

Research that matters

New Scientist reports on a year-long study to find the world’s funniest joke. The Internet-based project was coordinated by psychologist Richard Wiseman and colleagues at the University of Hertfordshire, U.K. and involved more than 2 million votes on 40,000 submissions. The goal was to identify universal aspects to humor, which could one day allow computers to devise truly funny jokes. Before we get to the winner, an interesting aside is that the team found in the process the world’s funniest animal: the duck. “If you’re going to tell a joke involving an animal, make it a duck,” Wiseman says. Now to the ultimate rib-tickler, which folks from Asia to Africa, the States to Siberia all seemed to enjoy. A couple of New Jersey hunters are out in the woods when one of them falls to the ground. He doesn’t seem to be breathing, his eyes are rolled back in his head. The other guy whips out his cell phone and calls the emergency services. He gasps to the operator: “My friend is dead! What can I do?” The operator, in a calm soothing voice, says: “Just take it easy. I can help. First, let’s make sure he’s dead.” There is a silence, then a shot is heard. The guy’s voice comes back on the line. He says: “OK, now what?” Thank you folks, I’ll be here all week.

New worm a real bear

PC users of the world beware! A new worm called BugBear is making the rounds, and New Scientist says it reflects a worrying new trend in virus code. Instead of disabling your computer, or turning it into a denial of service pod to flood other machines with garbage, BugBear contains a Trojan horse program that can collect credit card details, passwords and other private information stored from a computer and send it to a hacker. “When run, the Trojan disables anti-virus programs running on your machine,” New Scientists says. “It then installs a ‘keyboard sniffing’ program that remains in the background and copies every keystroke on your keyboard and saves them to a file. At some point later it opens a network connection and transmits the file to its creator, or bundles it up and sends it out as an email.” One side effect of the worm is that it tries to mail itself to any other machines on your network, including printers. So if you see unexpected, long junk printouts spewing for the LaserJet, you ought to get checked for infection.

See also:
>>BugBear at Sophos

Wascally Waksal

Though not strictly a science story, the Wall Street Journal has a devastating profile this morning of Sam Waksal, founder of ImClone. It’s a warning not only for directors of technology-based companies, but for investors and the media, who can be charmed by one person with a winning personality and a compelling story (in this case a promising cancer-fighting molecule). Terrific digging by reporter Geeta Anand reveals a string of research jobs from which Waksal was ousted for misleading and sometimes falsified results. Do yourself a favor and read this one through to the end. Suddenly Martha Stewart’s alleged insider trading of ImClone stock seems like the least of anyone’s worries about Waksal.

From the mouthes of Babe

This weekend I sank my teeth into some delicious beef ribs. But researchers at the Forsyth Institute say they’ve done one better ? they’ve sunk pork teeth into rat guts. The experiment involved taking seeded cells from immature teeth of six-month-old pigs and placing them in the intestines of rats (who no doubt were thrilled at the addition). Within 30 weeks, small tooth crowns made of enamel and dentin had formed. Within five years, the Forsythe team says, they hope to be able to harvest teeth of specific size and shape, and five years after that to regrow human teeth.

Device gives smart bombs a headache

Plans for GPS-guided bombs to do much of the heavy lifting in a U.S. war on Iraq could be seriously hampered by a $40 device available over the Internet. As reported by the Wall Street Journal, so-called global positioning system “jammers” can interrupt the system’s satellite signal. “At the Paris Air Show in 1999, a Russian company called Aviaconversia demonstrated a 4-watt GPS jammer, weighing about 19 pounds, capable of denying GPS reception for more than 100 miles,” the paper says. “While we do not know the extent of our vulnerability, there is evidence to suggest that GPS jamming can significantly inhibit precision targeting,” says Rep. Joseph Pitts (R., Penn.), co-chairman of Congress’ Electronic Warfare Working Group. So far the only known fix is to boost the GPS signal strength. But without new satellites in place, there’s only so far that approach can go.

Preparing for smallpox

Guidelines for inoculating the entire U.S. population against smallpox are being distributed to states today by federal health officials. At the moment mass vaccination is likely only if the deadly virus returns through an act of bio-terrorism. In the event of an outbreak, states would have to vaccinate their populations within days. (A person exposed to the virus can only be successfully immunized within five days of exposure.) The plan from the Centers for Disease Control and Prevention (CDC) shows states how to handle this massive effort, down to details like the number of hours a clinic would need to stay open (16), what to stress in public announcements (“urgency and patience, not panic”), the number of large-screens TVs needed per clinic (5, for video orientation), the temperature at which each brand of vaccine must be stored (varies), and the number of security personnel needed per 8-hour shift at a clinic (20). Smallpox is deadly, with a mortality rate of at least 30 percent. Because the disease was eradicated globally in the 1970s, most people have little immunity to it — and health workers aren’t familiar with it. Those facts plus the mobility of our plane-hopping poplulation mean that without extensive planning an outbreak could overwhelm public health systems.

Gonna fly now

It’s a technique Orville and Wilbur (God, I still love those names) Wright used a century ago to keep their early airplane afloat. Now the U.S. Air Force thinks it might have legs — or wings — again. It’s called wing warping. Instead of movable flaps and ailerons to steer and control a plane, warping bends the entire wing to achieve the desired effect. The Air Force has fancied it up a bit and redubbed it “active aeroelastic wing” technology. But the goal of its $41 million investment is, like the Brothers Wright, to produce lighter, more maneuverable planes. >> Related sites