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Researchers Say Deadly Twist Key To Sickle Cell Disease

Patients with sickle cell disease have mutant haemoglobin proteins that form deadly long, stiff fibres inside red blood cells. A research team led by University of Warwick researcher Dr Matthew Turner, propose a mathematical model in the 28 March online issue of PRL to explain the persistent stability of these deadly fibres. The theory suggests that an inherent “twistiness” in the strands that make up the fibres could be the key to their durability and possibly to new treatments.

Immunization may prove therapeutic for prion diseases

Researchers at NYU School of Medicine have found that immunization prolongs the incubation period for prion diseases such as Creutzfeldt-Jakob disease and may have therapeutic value for other neurodegenerative illness such as Alzheimer’s disease. Prion disease is a fatal brain disease manifested through failure of muscle control and dementia. Forms of this disease have been discovered in deer and elk (chronic wasting disease), in cows (bovine spongiform encephalopathy ? BSE ? or “mad cow disease”) and in sheep (scrapie strain).

Ibuprofen, aspirin may offer protection against Alzheimer's disease

Researchers have found evidence that non-steroidal anti-inflammatory drugs (NSAIDs) including ibuprofen, aspirin, and naproxen, may exert a protective effect against the risk of Alzheimer’s disease. Results of their epidemiological, multiple-study analysis of nearly 16,000 patients are being presented at the American Academy of Neurology Annual Meeting in Honolulu, March 29-April 5, 2003.

Component in plastic bottles found to cause abnormal pregnancies in mice

Researchers have found disturbing new evidence suggesting that environmental exposure to a ubiquitous substance may cause chromosomally abnormal pregnancies. They have learned that low levels of a compound used in the manufacture of common plastic food and beverage containers and baby bottles interfere with cell division in the eggs of female mice. The disruption of cell division can result in an abnormal number of chromosomes in the eggs, a condition known as aneuploidy, which is the leading cause of mental retardation and birth defects in humans. Down syndrome is an example of a disorder caused by the addition of an extra chromosome.

Ultra-Simple Desktop Device Slows Light to a Crawl

Though Einstein put his foot down and demanded that nothing can move faster than light, a new device developed at the University of Rochester may let you outpace a beam by putting your foot down on the gas pedal. At 127 miles per hour, the light in the new device travels more than 5 million times slower than normal as it passes through a ruby just a few centimeters long. Instead of the complex, room-filling mechanisms previously used to slow light, the new apparatus is small and, in the words of its creator, “ridiculously easy to implement.” Such a simple design will likely pave the way for slow light, as it is called, to move from a physical curiosity to a useful telecommunications tool. The research is being published in this week’s Physical Review Letters.

Risk of excess weight increases in unsafe neighborhoods

Missouri adults who say that they live in unsafe and unpleasant neighborhoods are one and a half times more likely to be overweight than adults who say they live in safe and pleasant communities, according to a new study. Unsafe traffic, crime and a lack of nice scenery in certain neighborhoods may keep residents from getting enough physical activity, which contributes to becoming or staying overweight, say Ross C. Brownson, Ph.D., of the St. Louis University School of Public Health and colleagues, who collaborated with the Missouri Department of Health and Senior Services on the study.

Liposuction-like procedure may harm body's immune system

A liposuction-like procedure called lipectomy results in a loss of humoral immune protection in two commonly studied rodent models, the prairie vole and the Siberian hamster, scientists have found. The report by a team of researchers at Indiana University, Ohio State University and Johns Hopkins University was made available online this week by The Royal Society. Their study is the first to show that even a moderate loss of fat leads to decreased amounts of infection-fighting IgG antibodies.

Two brain systems tell us to breathe

Until now, scientists believed that a single area in the brain generated breathing rhythm, enabling breathing to speed up or slow down to adapt to the body’s activity and position. But UCLA neurobiologists have discovered that two systems in the brain interact to generate breathing rhythm — a finding that may translate into better treatment for sleep apnea and sudden infant death syndrome. The journal Neuron reported the findings in its March 6 issue.

Dietary fat intake affects hidden stomach flab

You literally are what you eat, at least when it comes to the amount of abdominal visceral fat, Johns Hopkins researchers say. Studying the food diaries of a group of middle-age adults, they found that the more saturated fats such as butter and lard the group ate, the higher the amount of visceral fat surrounding their internal organs. By contrast, a diet of more polyunsaturated fats like vegetable oils yielded lower visceral fat.