Missing gene a potential risk factor for birth defects
Mouse embryos missing a gene that aids in the repair of DNA damage are at greater risk of developing birth defects, say scientists. The finding has implications for research into the cause of birth defects in humans. The gene, also found in humans, produces an important protein called ATM which senses DNA damage caused by reactive oxygen species and directs other proteins to repair it. Reactive oxygen species are a normal product of the body’s production of energy but can jump to toxic levels when cells are exposed to certain drugs, environmental chemicals and agents such as ionizing radiation.