Placebo controls—gold standard for EFFICACY trials—have no place in SAFETY trials
In a recent study of heart medications (REDUCE-IT), mineral oil was used as a “placebo”. Mineral oil is not a biological substance, and the body rejects it with nausea and diarrhea. Some of the adverse effects of mineral oil are listed here. There is no reason to use mineral oil as a “placebo” instead of (for example) olive … Read more