{"id":43,"date":"2021-04-27T18:46:03","date_gmt":"2021-04-27T18:46:03","guid":{"rendered":"http:\/\/experimentalfrontiers.peachpuff-wolverine-566518.hostingersite.com\/?p=43"},"modified":"2022-05-22T01:11:13","modified_gmt":"2022-05-22T01:11:13","slug":"trust-me-im-a-medical-researcher","status":"publish","type":"post","link":"https:\/\/scienceblog.com\/experimentalfrontiers\/2021\/04\/27\/trust-me-im-a-medical-researcher\/","title":{"rendered":"Trust me. I&#8217;m a medical researcher."},"content":{"rendered":"<p><em>I recently wrote an <a href=\"https:\/\/dailyinspirationblog.wordpress.com\/2021\/04\/01\/a-billion-here-a-billion-there\/\">April Fool piece<\/a> about an imaginary drug company that invested a billion dollars in a COVID vaccine, but when they ran it through Phase 3 clinical trials it fell just short of statistical significance for effectiveness. \u201cShucks! Back to the drawing board.\u201d They report the results exactly as they occurred and abandon the vaccine. The joke, of course, is that no drug company behaves in this way. From our vantage out here in consumerland, all vaccine trials are successful. Can you call it \u201cscience\u201d if there is only one acceptable outcome of the experiment? Banks that are \u201ctoo big to fail\u201d cost the public hundreds of billions of dollars. Drugs that are \u201ctoo big to fail\u201d can cost hundreds of thousands of lives.\u00a0<\/em><\/p>\n<p><em>How did we get to this place, where medical companies vie with tobacco companies for the least trusted industry in America? where, nevertheless, the companies that have a ginormous conflict of interest end up with the responsibility for safety-testing their own products? Where America\u2019s radio and TV stations are so dependent on direct-to-consumer drug ads for their largest single source of revenue that they shy away from reporting news that might have a negative impact on the bottom lines of Big Pharma?\u00a0\u00a0<\/em><\/p>\n<p><strong><em>Limited Hangout\u00a0<\/em><\/strong>(definition) An expos\u00e9 of a corrupt official or company that is actually sponsored by the target of the expos\u00e9. Hyperbolic language is used to condemn the target, but in fact, the worst abuses are omitted, leaving the impression that the official or company is less corrupt than, in fact, he is.<\/p>\n<p>Gerald Posner was known to me as a muckraking journalist who pulled punches. His twin assassination narratives concealed the roles played by US Intelligence services in arranging the murders of John F. Kennedy and Martin Luther King.<\/p>\n<p>His latest book,\u00a0<a href=\"https:\/\/www.simonandschuster.com\/books\/Pharma\/Gerald-Posner\/9781501152030\" target=\"_blank\" rel=\"noopener\"><strong><em>Pharma<\/em><\/strong><\/a>\u00a0paints a devastating portrait of America\u2019s most profitable industry. If\u00a0<strong><em>Pharma<\/em><\/strong>\u00a0is a limited hangout, then God help us!<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-44 aligncenter\" src=\"https:\/\/scienceblog.com\/wp-content\/uploads\/sites\/7\/2021\/04\/pharma_wposner.jpg__992x718_q90_subsampling-2-300x217.jpg\" alt=\"\" width=\"300\" height=\"217\" srcset=\"https:\/\/scienceblog.com\/experimentalfrontiers\/wp-content\/uploads\/sites\/7\/2021\/04\/pharma_wposner.jpg__992x718_q90_subsampling-2-300x217.jpg 300w, https:\/\/scienceblog.com\/experimentalfrontiers\/wp-content\/uploads\/sites\/7\/2021\/04\/pharma_wposner.jpg__992x718_q90_subsampling-2-768x556.jpg 768w, https:\/\/scienceblog.com\/experimentalfrontiers\/wp-content\/uploads\/sites\/7\/2021\/04\/pharma_wposner.jpg__992x718_q90_subsampling-2.jpg 992w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>Have you heard of the Sackler family? Forbes lists them as #30 among America\u2019s wealthiest, but their style is to keep a low profile. In the middle years of the last century, Arthur Sackler built his empire in pharmaceuticals, medical research, advertising, and philanthropy (!) while creating a new model for a vertically integrated industry.<\/p>\n<p>Sackler\u2019s genius was to create dozens of \u201cindependent\u201d companies and non-profits, all of which listed their headquarters as 17 E 62nd St in Manhattan. His echo chamber gave the impression of independent messages about his drug offerings that came from many directions, when in fact, there were many voices singing from the same hymnsheet. He reached for control of every aspect of the pharmaceutical business,<\/p>\n<ul>\n<li>\u201cCharitable\u201d support for research at the world\u2019s best medical schools<\/li>\n<li>Ownership of journals that published their results<\/li>\n<li>Ad agencies that did marketing campaigns for new drugs and slur campaigns against anyone who questioned their safety<\/li>\n<li>Drug companies placed expensive ads in the \u201cindependent\u201d journals, until the journals grew dependent on ad revenue.<\/li>\n<li>Opening the revolting door for FDA regulators, so that this year\u2019s \u201cregulators\u201d on a fixed government salary became next year\u2019s corporate executives with perks and stock options.<\/li>\n<li>Astroturf patient advocacy groups that demanded access to drugs and insurance coverage to pay for them<\/li>\n<li>The largest lobbying force of any industry, in DC and as well as state capitals<\/li>\n<li>\u201cEducational seminars\u201d for doctors including expense-paid junkets at luxury golf and beach resorts<\/li>\n<li>A computerized prescription-tracking system from the days before the Worldwide Web that supported&#8230;<\/li>\n<li>An army of commission-based salesmen, paid in proportion to the number of prescriptions written by their client doctors.<\/li>\n<li>PBMs purchased and controlled by drug companies. A PBM or \u201cpharmacy benefits manager\u201d negotiates drug discounts on behalf of insurance companies\u2014unless they are in the pocket of the same drug companies.<\/li>\n<\/ul>\n<p>Arthur Sackler was an American success story. He grew up in the same Brooklyn neighborhood as my father, raised by a Jewish immigrant couple from Eastern Europe who ran a grocery store before the Great War. He worked his way through medical school writing copy for a medical advertising agency, in the good old days when medical advertising was directed only at doctors and was grounded in facts and data. He completed a residency in psychiatry and advanced in the research world before his ambitions broadened to encompass research, advertising, drug development, and medical publishing.<\/p>\n<p>Sackler pioneered the \u201cpatent extension\u201d strategy for making tiny modifications to a drug\u2019s appearance or packaging the year before a patent was due to expire. When lethal side-effects were discovered in the course of clinical trials, the companies would routinely make a coldhearted decision about how much the eventual discovery of their deception would cut into corporate profits.\u00a0 Billions of dollars in fines and lawsuits for wrongful death were just a cost of doing business<\/p>\n<p>When Sackler started his career, drugs were associated with diseases, prescribed for people who were sick. Another of Sackler\u2019s innovations was to realize that the market of well people was far larger than people with diseases. At a time when W.H. Auden was writing poetry about the\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/The_Age_of_Anxiety\" target=\"_blank\" rel=\"noopener\">Age of Anxiety<\/a>\u00a0as a cultural malady, Sackler realized the profit potential in medicalizing anxiety as a nervous disorder. The Rolling Stones \u201c<a href=\"https:\/\/www.youtube.com\/watch?v=x-zxBNz3XbM\" target=\"_blank\" rel=\"noopener\">little yellow pill<\/a>\u201d was at one time taken by tens of millions of America\u2019s housewives, before the stories of abuse, addiction, and overdoses leaked out.<\/p>\n<p>The book culminates in an extensive account of Oxycontin. This was the one drug that was completely controlled by the Sackler family, developed and marketed by their private family firm,\u00a0<a href=\"https:\/\/www.npr.org\/2020\/11\/17\/936022386\/federal-judge-approves-landmark-8-3-billion-purdue-pharma-opioid-settlement\" target=\"_blank\" rel=\"noopener\">Purdue Pharma<\/a>. Purdue is the source of the wealth that earned the Sacklers\u2019 place on the Forbes list; and Oxycontin has been responsible for the greatest public health disaster in American history. At the same time the drug was aggressively marketed with \u201cdiscount cards\u201d that offered first prescriptions free, Oxycontin pills were fueling an epidemic of addiction and overdose deaths.<\/p>\n<p>Armies of Purdue sales reps were paid according to the number of Oxycontin prescriptions their physician-clients prescribed. \u201cThat physicians are susceptible to pseudoscience was, of course, something that Mortimer and Raymond [Sackler, Arthur\u2019s brothers] had learned decades earlier from Arthur and his major drug launches.\u201d<\/p>\n<p><strong>Limited Hangout?<\/strong><\/p>\n<p>After this devastating account of callous cupidity and a 50-year rape of American public health, is there anything missing? What could be worse?<\/p>\n<p>Vaccines.<\/p>\n<ul>\n<li>Vaccines are the single most profitable component of the pharmaceutical empire.<\/li>\n<li>Vaccines are the only drug exempted from placebo-controlled safety testing.<\/li>\n<li>Dozens of vaccines are mandated by law, administered to every child as a requirement for entering school<\/li>\n<li>And drug companies as well as doctors and hospitals have no liability when health problems, including irreversible neurological damage and chronic auto-immune diseases, are triggered by vaccines.<\/li>\n<li>Vaccines are the subject of the biggest taboo in journalism. Questioning the safety or efficacy of\u00a0<strong><em>any<\/em><\/strong>\u00a0vaccine product is the surest way to be blacklisted and censored. Armies of trolls commenting in social media help to enforce the ban on questioning the science of vaccines. If you ask any questions about vaccine safety, you must be \u201canti-science\u201d.<\/li>\n<\/ul>\n<p>Since the explosion in mandated vaccines, starting around 1990, America has suffered two epidemic explosion in childhood disease:<\/p>\n<ul>\n<li>Autism has increased in prevalence from 0.04% in 1980 to 1.70% as of 2018<\/li>\n<li>Auto-immune disorders have increased more modestly, but from a much larger base. 11% of Americans suffered auto-immune diseases in 1990, compared to 16% today.<\/li>\n<\/ul>\n<p>Plausible biological mechanisms make the connection between vaccines and both these disorders. Are vaccines responsible for increases in autism and autoimmunity? These are legitimate questions, but we are in an environment where anyone who asks them is being attacked and discredited.<\/p>\n<p>Do you, dear reader, know that\u00a0<a href=\"https:\/\/www.mdpi.com\/1660-4601\/17\/22\/8674\" target=\"_blank\" rel=\"noopener\">this 2019 study<\/a>\u00a0is the only long-term analysis of general effects of vaccination on children\u2019s health? The picture it paints is not pretty.<\/p>\n<p>Pfizer has a long and sordid history of\u00a0<a href=\"https:\/\/www.justice.gov\/opa\/pr\/justice-department-announces-largest-health-care-fraud-settlement-its-history\" target=\"_blank\" rel=\"noopener\">defrauding the FDA<\/a>\u00a0when applying for drug approvals. But who is casting a skeptical eye on their claim that the COVID mRNA vaccine is 95% effective, with only short-term side-effects? Here is an\u00a0<a href=\"https:\/\/blogs.bmj.com\/bmj\/2021\/01\/04\/peter-doshi-pfizer-and-modernas-95-effective-vaccines-we-need-more-details-and-the-raw-data\/\" target=\"_blank\" rel=\"noopener\">editorial by Peter Doshi<\/a>, senior editor of the British Medical Journal.\u00a0<span style=\"color: #222222\">Pfizer\u2019s application for FDA emergency approval is supported by just 170 COVID cases in all. They reported that only 8 were in the vaccine group and 162 in the placebo group. Sounds pretty good until you hear that there were an additional 3410 cases that were &#8220;suspected&#8221; COVID, but were not investigated further and not included in the study. These data were not disclosed to FDA. These \u201csuspected\u201d cases were split almost equally between vaccine group and placebo group. Do we really trust that Pfizer would resist the temptation to cherry-pick which cases were \u201csuspected\u201d and which were investigated?<\/span><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>I recently wrote an April Fool piece about an imaginary drug company that invested a billion dollars in a COVID vaccine, but when they ran it through Phase 3 clinical trials it fell just short of statistical significance for effectiveness. \u201cShucks! Back to the drawing board.\u201d They report the results exactly as they occurred and &#8230; <a title=\"Trust me. I&#8217;m a medical researcher.\" class=\"read-more\" href=\"https:\/\/scienceblog.com\/experimentalfrontiers\/2021\/04\/27\/trust-me-im-a-medical-researcher\/\" aria-label=\"Read more about Trust me. I&#8217;m a medical researcher.\">Read more<\/a><\/p>\n","protected":false},"author":65,"featured_media":44,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-43","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized","generate-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-50"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Trust me. I&#039;m a medical researcher. - Experimental Frontiers, with Josh Mitteldorf<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/scienceblog.com\/experimentalfrontiers\/2021\/04\/27\/trust-me-im-a-medical-researcher\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Trust me. I&#039;m a medical researcher.\" \/>\n<meta property=\"og:description\" content=\"I recently wrote an April Fool piece about an imaginary drug company that invested a billion dollars in a COVID vaccine, but when they ran it through Phase 3 clinical trials it fell just short of statistical significance for effectiveness. \u201cShucks! Back to the drawing board.\u201d They report the results exactly as they occurred and ... 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I&#8217;m a medical researcher.\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/scienceblog.com\\\/experimentalfrontiers\\\/#website\",\"url\":\"https:\\\/\\\/scienceblog.com\\\/experimentalfrontiers\\\/\",\"name\":\"Experimental Frontiers, with Josh Mitteldorf\",\"description\":\"Experimental Frontiers, with Josh Mitteldorf\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/scienceblog.com\\\/experimentalfrontiers\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/scienceblog.com\\\/experimentalfrontiers\\\/#\\\/schema\\\/person\\\/214c5d1dad9f15c48f03128d5cfccdb1\",\"name\":\"Josh Mitteldorf\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/d3a8498f3d727156673030716d233edc57840f110d501b1b523e1780e9043b92?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/d3a8498f3d727156673030716d233edc57840f110d501b1b523e1780e9043b92?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/d3a8498f3d727156673030716d233edc57840f110d501b1b523e1780e9043b92?s=96&d=mm&r=g\",\"caption\":\"Josh Mitteldorf\"},\"description\":\"Josh Mitteldorf studies evolutionary theory of aging using computer simulations. The surprising fact that our bodies are genetically programmed to age and to die offers an enormous opportunity for medical intervention. It may be that therapies to slow the progress of aging need not repair or regenerate anything, but only need to interfere with an existing program of self-destruction. Mitteldorf has taught a weekly yoga class for thirty years. He is an advocate for vigorous self care, including exercise, meditation and caloric restriction. After earning a PhD in astrophysicist, Mitteldorf moved to evolutionary biology as a primary field in 1996. He has taught at Harvard, Berkeley, Bryn Mawr, LaSalle and Temple University. He is presently affiliated with MIT as a visiting scholar. In private life, Mitteldorf is an advocate for election integrity as well as public health. He is an avid amateur musician, playing piano in chamber groups, French horn in community orchestras. His two daughters are among the first children adopted from China in the mid-1980s. Much to the surprise of evolutionary biologists, genetic experiments indicate that aging has been selected as an adaptation for its own sake. This poses a conundrum: the impact of aging on individual fitness is wholly negative, so aging must be regarded as a kind of evolutionary altruism. Unlike other forms of evolutionary altruism, aging offers benefits to the community that are weak, and not well focussed on near kin of the altruist. This makes the mechanism challenging to understand and to model. more at http:\\\/\\\/mathforum.org\\\/~josh\",\"sameAs\":[\"http:\\\/\\\/AgingAdvice.org\"],\"url\":\"https:\\\/\\\/scienceblog.com\\\/experimentalfrontiers\\\/author\\\/joshmitteldorf\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Trust me. 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The surprising fact that our bodies are genetically programmed to age and to die offers an enormous opportunity for medical intervention. It may be that therapies to slow the progress of aging need not repair or regenerate anything, but only need to interfere with an existing program of self-destruction. Mitteldorf has taught a weekly yoga class for thirty years. He is an advocate for vigorous self care, including exercise, meditation and caloric restriction. After earning a PhD in astrophysicist, Mitteldorf moved to evolutionary biology as a primary field in 1996. He has taught at Harvard, Berkeley, Bryn Mawr, LaSalle and Temple University. He is presently affiliated with MIT as a visiting scholar. In private life, Mitteldorf is an advocate for election integrity as well as public health. He is an avid amateur musician, playing piano in chamber groups, French horn in community orchestras. His two daughters are among the first children adopted from China in the mid-1980s. Much to the surprise of evolutionary biologists, genetic experiments indicate that aging has been selected as an adaptation for its own sake. This poses a conundrum: the impact of aging on individual fitness is wholly negative, so aging must be regarded as a kind of evolutionary altruism. Unlike other forms of evolutionary altruism, aging offers benefits to the community that are weak, and not well focussed on near kin of the altruist. This makes the mechanism challenging to understand and to model. more at http:\/\/mathforum.org\/~josh","sameAs":["http:\/\/AgingAdvice.org"],"url":"https:\/\/scienceblog.com\/experimentalfrontiers\/author\/joshmitteldorf\/"}]}},"jetpack_featured_media_url":"https:\/\/scienceblog.com\/experimentalfrontiers\/wp-content\/uploads\/sites\/7\/2021\/04\/pharma_wposner.jpg__992x718_q90_subsampling-2.jpg","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/scienceblog.com\/experimentalfrontiers\/wp-json\/wp\/v2\/posts\/43","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/scienceblog.com\/experimentalfrontiers\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/scienceblog.com\/experimentalfrontiers\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/scienceblog.com\/experimentalfrontiers\/wp-json\/wp\/v2\/users\/65"}],"replies":[{"embeddable":true,"href":"https:\/\/scienceblog.com\/experimentalfrontiers\/wp-json\/wp\/v2\/comments?post=43"}],"version-history":[{"count":0,"href":"https:\/\/scienceblog.com\/experimentalfrontiers\/wp-json\/wp\/v2\/posts\/43\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/scienceblog.com\/experimentalfrontiers\/wp-json\/wp\/v2\/media\/44"}],"wp:attachment":[{"href":"https:\/\/scienceblog.com\/experimentalfrontiers\/wp-json\/wp\/v2\/media?parent=43"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/scienceblog.com\/experimentalfrontiers\/wp-json\/wp\/v2\/categories?post=43"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/scienceblog.com\/experimentalfrontiers\/wp-json\/wp\/v2\/tags?post=43"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}