{"id":1449,"date":"2020-09-24T11:04:50","date_gmt":"2020-09-24T11:04:50","guid":{"rendered":"http:\/\/horizon.peachpuff-wolverine-566518.hostingersite.com\/?p=1449"},"modified":"2020-09-24T11:09:00","modified_gmt":"2020-09-24T11:09:00","slug":"qa-cancer-vaccines-will-not-replace-surgery-or-chemo-but-could-give-long-lasting-immunity","status":"publish","type":"post","link":"https:\/\/scienceblog.com\/horizon\/1449\/qa-cancer-vaccines-will-not-replace-surgery-or-chemo-but-could-give-long-lasting-immunity\/","title":{"rendered":"Q&A: \u2018Cancer vaccines will not replace surgery or chemo but could give long-lasting immunity\u2019"},"content":{"rendered":"
\n
\n
\n
by\u00a0Ian Le Guillou<\/h5>\n

A cancer vaccine needs to tackle the dual issues of cancers being able to hide from the immune system and suppress our immune defences. Recent advances are bringing cancer vaccines much closer to reality, giving patients another weapon in their arsenal of cancer treatments, according to Dr Madiha Derouazi, CEO of\u00a0<\/strong>Amal Therapeutics<\/strong><\/a>\u00a0and one of three winners of the 2020\u00a0<\/strong>EU Prize for Women Innovators<\/strong><\/a>.<\/strong><\/h3>\n<\/div>\n<\/div>\n<\/div>\n
\n
\n
\n

Arming our immune system to fight cancer has been a long-standing dream for scientists and doctors. However, many cancers have tricks that allow them to hide from the immune system and suppress our immune defences. To unleash our immune system we have to tackle both of these tricks.<\/p>\n

A revolution in immunology over the past decade led to the creation of immunotherapy drugs known as checkpoint inhibitors that reawaken the immune system. These drugs can have remarkable results in a minority of cases, leading to long-lasting remission.<\/p>\n

To work more broadly, we must also train the immune system to recognise the cancer. This is where vaccines could soon help us to target some of the most hard-to-treat cancers, says Dr Derouazi, whose company is currently running trials of a therapeutic vaccine in people with colorectal cancer.<\/p>\n

Vaccines are getting a lot of public attention at the moment in the battle against Covid-19. Most people are familiar with the idea of vaccinating against infectious diseases, but not against cancer. How would a cancer vaccine work?<\/strong><\/p>\n

Around 1891, a surgeon called Dr Coley noticed that when patients have cancer and also a bacterial infection at the same time, the tumour was shrinking. He developed a cocktail of bacteria that he administered to patients to treat the cancer, and sometimes there were quite impressive results. This drug, called Coley\u2019s toxins, was on the market until after the Second World War (when changes in FDA regulations required clinical trials for the drug to be approved for use).<\/p>\n

Your immune system spontaneously, or with some stimulation, can recognise the cancer cells as a threat and attack them. But the immune cells are not fully activated, so you need to give them a little help.<\/p>\n

How does your vaccine help the immune system to recognise the cancer?<\/strong><\/p>\n

Each type of vaccine platform has advantages and disadvantages. Vaccines using proteins are easier to manufacture than viruses. But proteins do not produce the immune response that you want. For a cancer vaccine you want to have cytotoxic T-cells (which kill cancer cells) and not necessarily antibodies. To achieve that, the protein has to be delivered in a certain way. To improve that I have added a cell-penetrating peptide (to deliver) the antigens.<\/p>\n

The other aspect is that you need to have the so-called \u2018danger signal\u2019 in order to get the immune system activated. So we could find some protein sequence which provides the danger signal and fuse it to the same protein. We end up with a chimeric protein where we have pieces assembled that keep the advantages that we will need to achieve a good immune response.<\/p>\n

We’re trying to have antigens which can (prompt the immune system to) target a lot of different cells in the tumour – not all the tumour cells express the same antigen. Also, we are addressing the genetic heterogeneity of human beings. So that’s why, for example, when you have to get a new organ, you have to find somebody who is compatible with you. We would like to have a vaccine which addresses this genetic heterogeneity and could work in Europe, Japan or the US, where the people are genetically very different.<\/p>\n

It’s innovative, but it’s not like I had the idea of the century when I woke up one morning. It has matured over 12 years of research in that space and thinking \u2018what can improve?\u2019, \u2018what have we learned?\u2019 and building on this knowledge.<\/p>\n

\n
\n

‘The vaccine will never work alone. It will not replace surgery or chemotherapy.’<\/p>\n

Dr Madiha Derouazi, CEO, Amal Therapeutics<\/p>\n<\/blockquote>\n<\/div>\n

Why have previous attempts to create a cancer vaccine failed?<\/strong><\/p>\n

I think immunology is one of the parts of life science, which has evolved the most over the past 10 years. So the people that were developing cancer vaccines 15 years ago had a dream to cure cancer with a vaccine, but we know now that it will not.<\/p>\n

The vaccine will never work alone. It will not replace surgery or chemotherapy. However, maybe after chemo and surgery, you can educate the immune system to recognise the cancer and have long-lasting immunity against the cancer, reducing the risk of relapse.<\/p>\n

Also, we were lacking some key knowledge in the immune suppressive mechanisms that the cancer cells have developed \u2013 how they escape the immune system.\u00a0 To fight against that, we have checkpoint inhibitor drugs, which over the last four or five years have completely changed the landscape of cancer treatment.<\/p>\n

It’s always a balance. You have what is promoting the immune system and you have what is suppressing the immune system. So if you want to win, you have to address both sides of the balance – promoting with the vaccine and removing the suppression with the checkpoint inhibitor.<\/p>\n

Five years ago, cancer vaccines were standalone, now it\u2019s always as a combination and that\u2019s very important.<\/p>\n

You are currently testing a vaccine for colorectal cancer using your \u2018chimeric protein\u2019 approach. What stage is the vaccine currently at?<\/strong><\/p>\n

It\u2019s in phase 1b clinical trial (for side effects and dosage in humans), where it\u2019s being tested in two populations of metastatic colorectal cancer patients. Within colorectal cancer, you have different populations based on their genetic background or based on where they are in the standard of care treatment.<\/p>\n

We chose colorectal cancer because in 2015, for the first time in immunotherapy, we had a genetic marker which allowed you to say if a colorectal cancer patient will respond to (the checkpoint inhibitor drug) anti-PD1. This is seen in about 4-5% of metastatic patients, and the remaining patients will not respond to this treatment. I was thinking that cancer vaccines should be used in patients where anti-PD1 is not working. It is not working for a reason and that could be addressed by the vaccine. A combination of a vaccine and anti-PD1 could get those patients to respond. So for colorectal cancer we had a clear differentiation (genetic) marker.<\/p>\n

At the beginning, this (trial) was planned for 32 patients, but this number will increase as soon as we see a signal (results that indicate the vaccine is effective).<\/p>\n

For a first-in-human trial, the primary endpoint is always safety, and then the secondary endpoints are clinical outcomes. You\u2019ll have the vaccine response in four or five months, but the clinical outcome takes a little bit longer \u2013 six to twelve months.<\/p>\n

I\u2019m very grateful to the patients who enrol in the trial because they not only get the treatment, but they also come a few times to give us some blood samples so we can follow the immune response.<\/p>\n

\n
\"Dr
Dr Derouazi says this year for the first time she\u2019s seen scientific publications on cancer vaccines with really promising results. Image credit – Liliroze<\/figcaption><\/figure>\n<\/div>\n

Why do you think your vaccine approach will be successful?<\/strong><\/p>\n

I\u2019m a lot more cautious in how I communicate about it. I get a lot of letters from patients requesting to be included in our trial or to get the vaccine under compassionate use, and it\u2019s very sad. I don\u2019t want to sell dreams to cancer patients; I don\u2019t want to oversell it.<\/p>\n

Where I think we are differentiating ourselves is that we are really trying to build up our technology platforms and clinical strategies on how the others have failed and what we have learned from their trials.<\/p>\n

It\u2019s an impossible question to answer, but when will we have a cancer vaccine available?<\/strong><\/p>\n

Ask me again next year! Honestly, we are much closer, because already in 2020, I have seen two scientific publications on cancer vaccines which, for the first time, have really promising results.<\/p>\n

I really believe that in the next five years, this will become a reality.<\/p>\n

On 23 September Dr Derouazi was awarded a \u20ac100,000 EU Women Innovators prize in recognition of her work. Her fellow winners, also awarded \u20ac100,000, were Maria F\u00e1tima Lucas, co-founder and CEO of Zymvol Biomodeling, and Aranzazu Mart\u00ednez co-founder and Managing Director of It Will Be. Josefien Groot, co-founder and CEO of Qlayers was named \u2018Rising Innovator\u2019 and awarded \u20ac50,000.<\/em><\/p>\n

Published by Horizon<\/a><\/em><\/p>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

by\u00a0Ian Le Guillou A cancer vaccine needs to tackle the dual issues of cancers being able to hide from the immune system and suppress our immune defences. Recent advances are bringing cancer vaccines much closer to reality, giving patients another weapon in their arsenal of cancer treatments, according to Dr Madiha Derouazi, CEO of\u00a0Amal Therapeutics\u00a0and … Read more<\/a><\/p>\n","protected":false},"author":298,"featured_media":1451,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"generate_page_header":"","jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[12],"tags":[],"class_list":["post-1449","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health"],"yoast_head":"\nQ&A: \u2018Cancer vaccines will not replace surgery or chemo but could give long-lasting immunity\u2019 - Horizon Magazine Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/scienceblog.com\/horizon\/1449\/qa-cancer-vaccines-will-not-replace-surgery-or-chemo-but-could-give-long-lasting-immunity\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Q&A: \u2018Cancer vaccines will not replace surgery or chemo but could give long-lasting immunity\u2019\" \/>\n<meta property=\"og:description\" content=\"by\u00a0Ian Le Guillou A cancer vaccine needs to tackle the dual issues of cancers being able to hide from the immune system and suppress our immune defences. Recent advances are bringing cancer vaccines much closer to reality, giving patients another weapon in their arsenal of cancer treatments, according to Dr Madiha Derouazi, CEO of\u00a0Amal Therapeutics\u00a0and ... Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/scienceblog.com\/horizon\/1449\/qa-cancer-vaccines-will-not-replace-surgery-or-chemo-but-could-give-long-lasting-immunity\/\" \/>\n<meta property=\"og:site_name\" content=\"Horizon Magazine Blog\" \/>\n<meta property=\"article:author\" content=\"https:\/\/www.facebook.com\/horizon.magazine.eu\" \/>\n<meta property=\"article:published_time\" content=\"2020-09-24T11:04:50+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-09-24T11:09:00+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2020\/09\/Women-vaccine.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"800\" \/>\n\t<meta property=\"og:image:height\" content=\"531\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Horizon Magazine\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@https:\/\/twitter.com\/HorizonMagEU\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Horizon Magazine\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"7 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/1449\\\/qa-cancer-vaccines-will-not-replace-surgery-or-chemo-but-could-give-long-lasting-immunity\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/1449\\\/qa-cancer-vaccines-will-not-replace-surgery-or-chemo-but-could-give-long-lasting-immunity\\\/\"},\"author\":{\"name\":\"Horizon Magazine\",\"@id\":\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/#\\\/schema\\\/person\\\/8f23522ba58f477f04dd574e1034f679\"},\"headline\":\"Q&A: \u2018Cancer vaccines will not replace surgery or chemo but could give long-lasting immunity\u2019\",\"datePublished\":\"2020-09-24T11:04:50+00:00\",\"dateModified\":\"2020-09-24T11:09:00+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/1449\\\/qa-cancer-vaccines-will-not-replace-surgery-or-chemo-but-could-give-long-lasting-immunity\\\/\"},\"wordCount\":1444,\"publisher\":{\"@id\":\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/1449\\\/qa-cancer-vaccines-will-not-replace-surgery-or-chemo-but-could-give-long-lasting-immunity\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/wp-content\\\/uploads\\\/sites\\\/4\\\/2020\\\/09\\\/Women-vaccine.jpg\",\"articleSection\":[\"Health\"],\"inLanguage\":\"en-US\",\"copyrightYear\":\"2020\",\"copyrightHolder\":{\"@id\":\"https:\\\/\\\/scienceblog.com\\\/#organization\"}},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/1449\\\/qa-cancer-vaccines-will-not-replace-surgery-or-chemo-but-could-give-long-lasting-immunity\\\/\",\"url\":\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/1449\\\/qa-cancer-vaccines-will-not-replace-surgery-or-chemo-but-could-give-long-lasting-immunity\\\/\",\"name\":\"Q&A: \u2018Cancer vaccines will not replace surgery or chemo but could give long-lasting immunity\u2019 - Horizon Magazine Blog\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/1449\\\/qa-cancer-vaccines-will-not-replace-surgery-or-chemo-but-could-give-long-lasting-immunity\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/1449\\\/qa-cancer-vaccines-will-not-replace-surgery-or-chemo-but-could-give-long-lasting-immunity\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/wp-content\\\/uploads\\\/sites\\\/4\\\/2020\\\/09\\\/Women-vaccine.jpg\",\"datePublished\":\"2020-09-24T11:04:50+00:00\",\"dateModified\":\"2020-09-24T11:09:00+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/1449\\\/qa-cancer-vaccines-will-not-replace-surgery-or-chemo-but-could-give-long-lasting-immunity\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/1449\\\/qa-cancer-vaccines-will-not-replace-surgery-or-chemo-but-could-give-long-lasting-immunity\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/1449\\\/qa-cancer-vaccines-will-not-replace-surgery-or-chemo-but-could-give-long-lasting-immunity\\\/#primaryimage\",\"url\":\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/wp-content\\\/uploads\\\/sites\\\/4\\\/2020\\\/09\\\/Women-vaccine.jpg\",\"contentUrl\":\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/wp-content\\\/uploads\\\/sites\\\/4\\\/2020\\\/09\\\/Women-vaccine.jpg\",\"width\":800,\"height\":531,\"caption\":\"A cancer vaccine needs to tackle the dual issues of cancers being able to hide from the immune system and suppress our immune defences.\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/1449\\\/qa-cancer-vaccines-will-not-replace-surgery-or-chemo-but-could-give-long-lasting-immunity\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Q&A: \u2018Cancer vaccines will not replace surgery or chemo but could give long-lasting immunity\u2019\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/#website\",\"url\":\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/\",\"name\":\"Horizon Magazine Blog\",\"description\":\"The EU Research & Innovation Magazine\",\"publisher\":{\"@id\":\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/#organization\",\"name\":\"Horizon Magazine Blog\",\"url\":\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/wp-content\\\/uploads\\\/sites\\\/4\\\/2026\\\/04\\\/eu-logo.jpg\",\"contentUrl\":\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/wp-content\\\/uploads\\\/sites\\\/4\\\/2026\\\/04\\\/eu-logo.jpg\",\"width\":601,\"height\":283,\"caption\":\"Horizon Magazine Blog\"},\"image\":{\"@id\":\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/#\\\/schema\\\/logo\\\/image\\\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/#\\\/schema\\\/person\\\/8f23522ba58f477f04dd574e1034f679\",\"name\":\"Horizon Magazine\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/407bd816be829798850d5e7f646c4137f70c86c6af6c761b67a6ea80c364ffa4?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/407bd816be829798850d5e7f646c4137f70c86c6af6c761b67a6ea80c364ffa4?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/407bd816be829798850d5e7f646c4137f70c86c6af6c761b67a6ea80c364ffa4?s=96&d=mm&r=g\",\"caption\":\"Horizon Magazine\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/horizon.magazine.eu\",\"https:\\\/\\\/x.com\\\/https:\\\/\\\/twitter.com\\\/HorizonMagEU\"],\"url\":\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/author\\\/horizonmagazine\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Q&A: \u2018Cancer vaccines will not replace surgery or chemo but could give long-lasting immunity\u2019 - Horizon Magazine Blog","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/scienceblog.com\/horizon\/1449\/qa-cancer-vaccines-will-not-replace-surgery-or-chemo-but-could-give-long-lasting-immunity\/","og_locale":"en_US","og_type":"article","og_title":"Q&A: \u2018Cancer vaccines will not replace surgery or chemo but could give long-lasting immunity\u2019","og_description":"by\u00a0Ian Le Guillou A cancer vaccine needs to tackle the dual issues of cancers being able to hide from the immune system and suppress our immune defences. Recent advances are bringing cancer vaccines much closer to reality, giving patients another weapon in their arsenal of cancer treatments, according to Dr Madiha Derouazi, CEO of\u00a0Amal Therapeutics\u00a0and ... Read more","og_url":"https:\/\/scienceblog.com\/horizon\/1449\/qa-cancer-vaccines-will-not-replace-surgery-or-chemo-but-could-give-long-lasting-immunity\/","og_site_name":"Horizon Magazine Blog","article_author":"https:\/\/www.facebook.com\/horizon.magazine.eu","article_published_time":"2020-09-24T11:04:50+00:00","article_modified_time":"2020-09-24T11:09:00+00:00","og_image":[{"width":800,"height":531,"url":"https:\/\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2020\/09\/Women-vaccine.jpg","type":"image\/jpeg"}],"author":"Horizon Magazine","twitter_card":"summary_large_image","twitter_creator":"@https:\/\/twitter.com\/HorizonMagEU","twitter_misc":{"Written by":"Horizon Magazine","Est. reading time":"7 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/scienceblog.com\/horizon\/1449\/qa-cancer-vaccines-will-not-replace-surgery-or-chemo-but-could-give-long-lasting-immunity\/#article","isPartOf":{"@id":"https:\/\/scienceblog.com\/horizon\/1449\/qa-cancer-vaccines-will-not-replace-surgery-or-chemo-but-could-give-long-lasting-immunity\/"},"author":{"name":"Horizon Magazine","@id":"https:\/\/scienceblog.com\/horizon\/#\/schema\/person\/8f23522ba58f477f04dd574e1034f679"},"headline":"Q&A: \u2018Cancer vaccines will not replace surgery or chemo but could give long-lasting immunity\u2019","datePublished":"2020-09-24T11:04:50+00:00","dateModified":"2020-09-24T11:09:00+00:00","mainEntityOfPage":{"@id":"https:\/\/scienceblog.com\/horizon\/1449\/qa-cancer-vaccines-will-not-replace-surgery-or-chemo-but-could-give-long-lasting-immunity\/"},"wordCount":1444,"publisher":{"@id":"https:\/\/scienceblog.com\/horizon\/#organization"},"image":{"@id":"https:\/\/scienceblog.com\/horizon\/1449\/qa-cancer-vaccines-will-not-replace-surgery-or-chemo-but-could-give-long-lasting-immunity\/#primaryimage"},"thumbnailUrl":"https:\/\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2020\/09\/Women-vaccine.jpg","articleSection":["Health"],"inLanguage":"en-US","copyrightYear":"2020","copyrightHolder":{"@id":"https:\/\/scienceblog.com\/#organization"}},{"@type":"WebPage","@id":"https:\/\/scienceblog.com\/horizon\/1449\/qa-cancer-vaccines-will-not-replace-surgery-or-chemo-but-could-give-long-lasting-immunity\/","url":"https:\/\/scienceblog.com\/horizon\/1449\/qa-cancer-vaccines-will-not-replace-surgery-or-chemo-but-could-give-long-lasting-immunity\/","name":"Q&A: \u2018Cancer vaccines will not replace surgery or chemo but could give long-lasting immunity\u2019 - Horizon Magazine Blog","isPartOf":{"@id":"https:\/\/scienceblog.com\/horizon\/#website"},"primaryImageOfPage":{"@id":"https:\/\/scienceblog.com\/horizon\/1449\/qa-cancer-vaccines-will-not-replace-surgery-or-chemo-but-could-give-long-lasting-immunity\/#primaryimage"},"image":{"@id":"https:\/\/scienceblog.com\/horizon\/1449\/qa-cancer-vaccines-will-not-replace-surgery-or-chemo-but-could-give-long-lasting-immunity\/#primaryimage"},"thumbnailUrl":"https:\/\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2020\/09\/Women-vaccine.jpg","datePublished":"2020-09-24T11:04:50+00:00","dateModified":"2020-09-24T11:09:00+00:00","breadcrumb":{"@id":"https:\/\/scienceblog.com\/horizon\/1449\/qa-cancer-vaccines-will-not-replace-surgery-or-chemo-but-could-give-long-lasting-immunity\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/scienceblog.com\/horizon\/1449\/qa-cancer-vaccines-will-not-replace-surgery-or-chemo-but-could-give-long-lasting-immunity\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/scienceblog.com\/horizon\/1449\/qa-cancer-vaccines-will-not-replace-surgery-or-chemo-but-could-give-long-lasting-immunity\/#primaryimage","url":"https:\/\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2020\/09\/Women-vaccine.jpg","contentUrl":"https:\/\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2020\/09\/Women-vaccine.jpg","width":800,"height":531,"caption":"A cancer vaccine needs to tackle the dual issues of cancers being able to hide from the immune system and suppress our immune defences."},{"@type":"BreadcrumbList","@id":"https:\/\/scienceblog.com\/horizon\/1449\/qa-cancer-vaccines-will-not-replace-surgery-or-chemo-but-could-give-long-lasting-immunity\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/scienceblog.com\/horizon\/"},{"@type":"ListItem","position":2,"name":"Q&A: \u2018Cancer vaccines will not replace surgery or chemo but could give long-lasting immunity\u2019"}]},{"@type":"WebSite","@id":"https:\/\/scienceblog.com\/horizon\/#website","url":"https:\/\/scienceblog.com\/horizon\/","name":"Horizon Magazine Blog","description":"The EU Research & Innovation Magazine","publisher":{"@id":"https:\/\/scienceblog.com\/horizon\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/scienceblog.com\/horizon\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/scienceblog.com\/horizon\/#organization","name":"Horizon Magazine Blog","url":"https:\/\/scienceblog.com\/horizon\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/scienceblog.com\/horizon\/#\/schema\/logo\/image\/","url":"https:\/\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2026\/04\/eu-logo.jpg","contentUrl":"https:\/\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2026\/04\/eu-logo.jpg","width":601,"height":283,"caption":"Horizon Magazine Blog"},"image":{"@id":"https:\/\/scienceblog.com\/horizon\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/scienceblog.com\/horizon\/#\/schema\/person\/8f23522ba58f477f04dd574e1034f679","name":"Horizon Magazine","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/407bd816be829798850d5e7f646c4137f70c86c6af6c761b67a6ea80c364ffa4?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/407bd816be829798850d5e7f646c4137f70c86c6af6c761b67a6ea80c364ffa4?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/407bd816be829798850d5e7f646c4137f70c86c6af6c761b67a6ea80c364ffa4?s=96&d=mm&r=g","caption":"Horizon Magazine"},"sameAs":["https:\/\/www.facebook.com\/horizon.magazine.eu","https:\/\/x.com\/https:\/\/twitter.com\/HorizonMagEU"],"url":"https:\/\/scienceblog.com\/horizon\/author\/horizonmagazine\/"}]}},"jetpack_featured_media_url":"https:\/\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2020\/09\/Women-vaccine.jpg","jetpack_shortlink":"https:\/\/wp.me\/pgtNKV-nn","jetpack_sharing_enabled":true,"jetpack-related-posts":[{"id":1690,"url":"https:\/\/scienceblog.com\/horizon\/1690\/qa-biontech-vaccine-is-only-mrna-1-0-this-is-just-the-beginning-say-co-founders\/","url_meta":{"origin":1449,"position":0},"title":"Q&A: BioNTech vaccine is only \u2018mRNA 1.0\u2019. This is just the beginning, say co-founders","author":"Joanna Roberts","date":"April 8, 2021","format":false,"excerpt":"The successful development of\u00a0mRNA vaccines\u00a0for Covid-19 is \u2018transformational\u2019 and opens the doors to new types of vaccines for other infectious diseases as well as cancer, according to Dr \u00d6zlem T\u00fcreci and Dr U\u011fur \u015eahin, the co-founders of Germany\u2019s BioNTech. The main question, they say, is which vaccine to prioritise first.\u2026","rel":"","context":"In "Health"","block_context":{"text":"Health","link":"https:\/\/scienceblog.com\/horizon\/category\/health\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2021\/04\/Montage1.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2021\/04\/Montage1.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2021\/04\/Montage1.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2021\/04\/Montage1.jpg?resize=700%2C400&ssl=1 2x"},"classes":[]},{"id":784,"url":"https:\/\/scienceblog.com\/horizon\/784\/danish-dogs-to-receive-virus-inspired-cancer-vaccine-treatment\/","url_meta":{"origin":1449,"position":1},"title":"Danish dogs to receive virus-inspired cancer vaccine treatment","author":"Aisling Irwin","date":"April 23, 2019","format":false,"excerpt":"Fifteen Danish dogs with advanced cancer are to receive a new type of therapeutic vaccine which, it is hoped, will rid them of the disease and pave the way for human testing. Unlike preventative vaccines, therapeutic vaccines are not used to prevent someone from getting a disease but rather to\u2026","rel":"","context":"In "Health"","block_context":{"text":"Health","link":"https:\/\/scienceblog.com\/horizon\/category\/health\/"},"img":{"alt_text":"Researchers are testing the therapeutic vaccine on dogs with the hope that trials could progress to humans. Image Credit - Pixabay\/No License","src":"https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2019\/04\/doggycrop.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2019\/04\/doggycrop.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2019\/04\/doggycrop.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2019\/04\/doggycrop.jpg?resize=700%2C400&ssl=1 2x"},"classes":[]},{"id":121,"url":"https:\/\/scienceblog.com\/horizon\/121\/fighting-cancer-with-nanobodies-and-computer-simulations\/","url_meta":{"origin":1449,"position":2},"title":"Fighting cancer with nanobodies and computer simulations","author":"Catherine Collins","date":"February 2, 2018","format":false,"excerpt":"Stimulating or enhancing someone\u2019s own\u00a0immune system to fight cancer\u00a0is not a new concept but scientists are taking it one step further by using nanoscience and computer simulations to improve existing treatments. Immunotherapy drugs are specifically designed to help the immune system respond to cancerous cells, something that it doesn\u2019t naturally\u2026","rel":"","context":"In "Health"","block_context":{"text":"Health","link":"https:\/\/scienceblog.com\/horizon\/category\/health\/"},"img":{"alt_text":"Researchers in the Netherlands are hoping to move vaccine therapy from the lab to inside the body.","src":"https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2018\/02\/petri-dish-2000-e1648216038606.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2018\/02\/petri-dish-2000-e1648216038606.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2018\/02\/petri-dish-2000-e1648216038606.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2018\/02\/petri-dish-2000-e1648216038606.jpg?resize=700%2C400&ssl=1 2x"},"classes":[]},{"id":1217,"url":"https:\/\/scienceblog.com\/horizon\/1217\/five-things-you-need-to-know-about-mrna-vaccines\/","url_meta":{"origin":1449,"position":3},"title":"Five things you need to know about: mRNA vaccines","author":"Joanna Roberts","date":"April 1, 2020","format":false,"excerpt":"The race for a vaccine against the novel coronavirus, or SARS-CoV-2, is on, with\u00a054 different vaccines under development, two of which are already being tested in humans, according to the World Health Organization. And among the different candidates is a new player on the scene \u2013 mRNA vaccines. One mRNA\u2026","rel":"","context":"In "Health"","block_context":{"text":"Health","link":"https:\/\/scienceblog.com\/horizon\/category\/health\/"},"img":{"alt_text":"According to Prof. Bekeredjian-Ding, an approved mRNA coronavirus vaccine would be easier and faster to produce and thus deploy worldwide than a conventional vaccine. Image credit - Unsplash\/Liliya Lisa","src":"https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2020\/04\/liliya-lisa-sm.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2020\/04\/liliya-lisa-sm.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2020\/04\/liliya-lisa-sm.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2020\/04\/liliya-lisa-sm.jpg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2020\/04\/liliya-lisa-sm.jpg?resize=1050%2C600&ssl=1 3x"},"classes":[]},{"id":1523,"url":"https:\/\/scienceblog.com\/horizon\/1523\/five-things-you-need-to-know-about-mrna-vaccine-safety\/","url_meta":{"origin":1449,"position":4},"title":"Five things you need to know about: mRNA vaccine safety","author":"Horizon Magazine","date":"December 11, 2020","format":false,"excerpt":"The world\u2019s first mRNA vaccine has\u00a0begun its rollout\u00a0after being produced at unprecedented speed as part of the global effort to end the Covid-19 pandemic. A second one is hot on its heels. The two \u2013 one made by Pfizer\/BioNTech and the other by Moderna \u2013 mark the first time this\u2026","rel":"","context":"In "Health"","block_context":{"text":"Health","link":"https:\/\/scienceblog.com\/horizon\/category\/health\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2020\/12\/ChildVaccine.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2020\/12\/ChildVaccine.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2020\/12\/ChildVaccine.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2020\/12\/ChildVaccine.jpg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2020\/12\/ChildVaccine.jpg?resize=1050%2C600&ssl=1 3x"},"classes":[]},{"id":971,"url":"https:\/\/scienceblog.com\/horizon\/971\/will-we-ever-cure-cancer\/","url_meta":{"origin":1449,"position":5},"title":"Will we ever cure cancer?","author":"Horizon Magazine","date":"September 18, 2019","format":false,"excerpt":"Cancer is a group of diseases that we may never be able to cure completely, but scientists are optimistic that vaccines, personalised medicine and smart lifestyle choices will help prevent and treat a much greater proportion of cases than currently happens. We asked three cancer experts - Nobel laureate Professor\u2026","rel":"","context":"In "Health"","block_context":{"text":"Health","link":"https:\/\/scienceblog.com\/horizon\/category\/health\/"},"img":{"alt_text":"Many of the risk factors to do with cancer are related to lifestyle, so there is concrete action people can take to avoid getting the disease. Image credit - Pixabay\/ MabelAmber, licensed under pixabay license","src":"https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2019\/09\/jogging-1509003_1280.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2019\/09\/jogging-1509003_1280.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2019\/09\/jogging-1509003_1280.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2019\/09\/jogging-1509003_1280.jpg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2019\/09\/jogging-1509003_1280.jpg?resize=1050%2C600&ssl=1 3x"},"classes":[]}],"_links":{"self":[{"href":"https:\/\/scienceblog.com\/horizon\/wp-json\/wp\/v2\/posts\/1449","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/scienceblog.com\/horizon\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/scienceblog.com\/horizon\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/scienceblog.com\/horizon\/wp-json\/wp\/v2\/users\/298"}],"replies":[{"embeddable":true,"href":"https:\/\/scienceblog.com\/horizon\/wp-json\/wp\/v2\/comments?post=1449"}],"version-history":[{"count":0,"href":"https:\/\/scienceblog.com\/horizon\/wp-json\/wp\/v2\/posts\/1449\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/scienceblog.com\/horizon\/wp-json\/wp\/v2\/media\/1451"}],"wp:attachment":[{"href":"https:\/\/scienceblog.com\/horizon\/wp-json\/wp\/v2\/media?parent=1449"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/scienceblog.com\/horizon\/wp-json\/wp\/v2\/categories?post=1449"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/scienceblog.com\/horizon\/wp-json\/wp\/v2\/tags?post=1449"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}