{"id":1523,"date":"2020-12-11T13:07:38","date_gmt":"2020-12-11T13:07:38","guid":{"rendered":"http:\/\/horizon.peachpuff-wolverine-566518.hostingersite.com\/?p=1523"},"modified":"2020-12-11T13:07:38","modified_gmt":"2020-12-11T13:07:38","slug":"five-things-you-need-to-know-about-mrna-vaccine-safety","status":"publish","type":"post","link":"https:\/\/scienceblog.com\/horizon\/1523\/five-things-you-need-to-know-about-mrna-vaccine-safety\/","title":{"rendered":"Five things you need to know about: mRNA vaccine safety"},"content":{"rendered":"
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The world\u2019s first mRNA vaccine has\u00a0<\/strong>begun its rollout<\/strong><\/a>\u00a0after being produced at unprecedented speed as part of the global effort to end the Covid-19 pandemic. A second one is hot on its heels. The two \u2013 one made by Pfizer\/BioNTech and the other by Moderna \u2013 mark the first time this vaccine technology has been approved for use.<\/strong><\/p>\n<\/div>\n<\/div>\n<\/div>\n

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In trials these vaccines have shown to be at least 94% effective at preventing people from falling ill with Covid-19. But how safe is this new technology? We spoke to Michel Goldman, a professor of immunology and founder of the I3h Institute for Interdisciplinary Innovation in healthcare at the Universit\u00e9 Libre de Bruxelles in Belgium. Here are five things to know.<\/p>\n

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  1. mRNA vaccine technology is not entirely new<\/strong><\/li>\n<\/ol>\n

    Vaccines\u00a0such as the inactivated polio vaccine, or most flu vaccines, use inactivated viruses\u00a0to trigger a person\u2019s immune system to respond to that disease-causing organism. In other vaccines, such as the hepatitis B vaccine, an individual protein made by that organism is injected instead to trigger a similar response.<\/p>\n

    mRNA vaccines, however, trick the body into making the viral protein itself which, in turn, triggers an immune response.<\/p>\n

    Although the COVID-19 vaccines made by Pfizer\/BioNTech are the first mRNA vaccines to complete all clinical trial stages and be licensed for use, the technology has been around for a while.<\/p>\n

    Human trials of cancer vaccines using the same mRNA technology have been taking place since 2011. \u2018If there was a real problem with the technology, we\u2019d have seen it before now for sure,\u2019 said Prof. Goldman.<\/p>\n

    Because the technology can be deployed extremely rapidly, and clinical trials have been so successful, mRNA platforms will be an important means of preparing for future epidemics, he says.<\/p>\n

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    1. mRNA vaccines do not alter your DNA<\/strong><\/li>\n<\/ol>\n

      A concern that some have had about the mRNA vaccines is that they could change people\u2019s DNA. But that idea is \u2018completely false\u2019 and has \u2018no scientific basis\u2019, says Prof. Goldman.<\/p>\n

      \u2018The (vaccine)\u00a0mRNA will not enter the nucleus of the cells, where our DNA is.\u2019<\/p>\n

      Once the injected mRNA enters a human cell, it degrades quickly and only stays in the body for a couple of days.\u00a0This is why people need two injections to develop the best immune response, he says.<\/p>\n

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      \u2018The highest risk right now (especially for vulnerable people) is not to be vaccinated.\u2019<\/p>\n

      -Prof. Michel Goldman, Universit\u00e9 Libre de Bruxelles, Belgium<\/span><\/p>\n<\/blockquote>\n

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      1. mRNA vaccines are very specific<\/strong><\/li>\n<\/ol>\n

        The novel coronavirus, or SARS-CoV-2, has a complex structure, and different parts of the virus trigger the immune system to produce different antibodies to neutralise the virus.<\/p>\n

        If an unvaccinated person catches the virus, they will produce antibodies that prevent the virus from entering human cells. They may also generate antibodies that do not have much impact. And in some cases, a person may produce antibodies which actually help the virus enter cells.<\/p>\n

        mRNA vaccines are much more specific. They are designed to only trigger an immune response to the virus\u2019s spike protein, which is just one component of the viral membrane and enables the virus to invade our cells.<\/p>\n

        To be sure this is the case, researchers are carefully monitoring that the vaccine does not trigger an unwanted immune response.<\/p>\n

        \u2018So far this has not been shown for the (Covid-19) vaccines.\u2019 But it \u2018will remain important to ensure the immune response triggered by the vaccine is focused on the viral spike protein,\u2019 said Prof. Goldman.<\/p>\n

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        1. Corners were not cut in the clinical trials and approvals process<\/strong><\/li>\n<\/ol>\n

          Vaccine trials take place in stages, starting with trials on animals, and then three trials on people \u2013 Phase 1, Phase 2 and finally Phase 3.<\/p>\n

          The Pfizer\/BioNTech vaccine Phase 3 trial involved more than\u00a040,000 people<\/a>. It began in July and will continue to collect efficacy and safety data for another two years.<\/p>\n

          Safety issues\u00a0that would affect significant numbers of\u00a0vaccines mostly appear within two months, Prof. Goldman says.<\/p>\n

          However, after a vaccine is given to millions of people, very rare side effects that cannot be anticipated from clinical trials might develop, so researchers and regulators will be keeping a close eye on how the vaccine rollout goes. This will be especially important for Covid-19 vaccines based on innovative technology.<\/p>\n

          Regulatory agencies reviewed the data from Covid-19 vaccine trials more quickly than usual by looking at it on a rolling basis rather than only once the trials were complete, but they did not fundamentally change their rules. \u2018I really don\u2019t think that corners were cut in terms of safety,\u2019 said Prof. Goldman.<\/p>\n

          The process was faster than usual because researchers had already built an mRNA platform \u2013 a way of getting viral mRNA into the body \u2013 for cancer and other vaccines under trial. It meant this could be put into action as soon as the genomic sequence of the virus was shared.<\/p>\n

          Companies and governments also took the risk of producing large numbers of vaccines even before the the first stages of experimentation had been completed, which meant they were ready to begin\u00a0large human trials as soon as the results were in.<\/p>\n

          \u2018It\u2019s a financial risk, because if you were wrong all this is lost. That\u2019s why the risk is shared between the private companies and the governments,\u2019 said Prof. Goldman.<\/p>\n

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          1. The vaccine triggers an inflammatory response<\/strong><\/li>\n<\/ol>\n

            The vaccine partly works by inducing local inflammatory reactions to trigger the immune system. This means that it\u2019s normal for many people to experience pain at the site of the injection and sometimes fever and discomfort for one or two days after the vaccine.<\/p>\n

            \u2018This is something that has not been advertised enough,\u2019 says Prof. Goldman.<\/p>\n

            A\u00a0November survey<\/a>\u00a0in 15 countries found 54% of people were worried about possible side effects from a Covid-19 vaccine.<\/p>\n

            One unwanted response to the Pfizer-BioNTech mRNA vaccine came to light during the first day of mass vaccination in the UK after two people with a history of significant allergies\u00a0reacted to the injection<\/a>. The UK regulatory authority\u00a0updated its advice<\/a>\u00a0to specify that people with a history of anaphylaxis to medicine or food should not get the shot.<\/p>\n

            In the clinical trials, allergic reactions occurred in 0.63% of people given the Pfizer-BioNTech vaccine, and in 0.5% of people given a placebo.<\/p>\n

            \u2018My main concern is that people will use (possible side-effects) as an argument not to be vaccinated,\u2019 said Prof. Goldman \u2018The highest risk right now (especially for vulnerable people) is not to be vaccinated.\u2019<\/p>\n

            Prof. Goldman was the first executive director of the Innovative Medicines Initiative, a partnership between the EU and the European pharmaceutical industry to speed up the development of, and access to, innovative medicines.<\/em><\/p>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

            The world\u2019s first mRNA vaccine has\u00a0begun its rollout\u00a0after being produced at unprecedented speed as part of the global effort to end the Covid-19 pandemic. A second one is hot on its heels. The two \u2013 one made by Pfizer\/BioNTech and the other by Moderna \u2013 mark the first time this vaccine technology has been approved … Read more<\/a><\/p>\n","protected":false},"author":298,"featured_media":1524,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"generate_page_header":"","jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[12],"tags":[359,360,37,252],"class_list":["post-1523","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health","tag-coronavirus","tag-covid-19","tag-health","tag-vaccine"],"yoast_head":"\nFive things you need to know about: mRNA vaccine safety - Horizon Magazine Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/scienceblog.com\/horizon\/1523\/five-things-you-need-to-know-about-mrna-vaccine-safety\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Five things you need to know about: mRNA vaccine safety\" \/>\n<meta property=\"og:description\" content=\"The world\u2019s first mRNA vaccine has\u00a0begun its rollout\u00a0after being produced at unprecedented speed as part of the global effort to end the Covid-19 pandemic. 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After nearly two decades of working in vaccine development, seeing the subject of her work \u2013 coronavirus \u2013 in the news every single day is a first for her. \u2018It's very exciting and very motivational, but there is a lot of\u2026","rel":"","context":"In "Health"","block_context":{"text":"Health","link":"https:\/\/scienceblog.com\/horizon\/category\/health\/"},"img":{"alt_text":"CureVac began testing its mRNA vaccine candidate in people in mid-June and will shortly proceed to the next phase of trials. 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Surveys conducted\u2026","rel":"","context":"In "Health"","block_context":{"text":"Health","link":"https:\/\/scienceblog.com\/horizon\/category\/health\/"},"img":{"alt_text":"People\u2019s willingness to have a vaccine changes depending on how at risk they feel, says anthropologist Heidi Larson. 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