{"id":1780,"date":"2021-08-10T05:55:40","date_gmt":"2021-08-10T05:55:40","guid":{"rendered":"https:\/\/horizon.peachpuff-wolverine-566518.hostingersite.com\/?p=1780"},"modified":"2021-08-10T05:55:40","modified_gmt":"2021-08-10T05:55:40","slug":"antifreeze-fish-inspire-new-cryoprotectants-for-human-cells-and-tissues","status":"publish","type":"post","link":"https:\/\/scienceblog.com\/horizon\/1780\/antifreeze-fish-inspire-new-cryoprotectants-for-human-cells-and-tissues\/","title":{"rendered":"Antifreeze fish inspire new cryoprotectants for human cells and tissues"},"content":{"rendered":"

The idea of cryogenically freezing a person to preserve their body until many years into the future has long been a staple of science fiction stories. However, the need to reliably store biological materials such as cells or tissue is a common concern for scientific research and, increasingly, for society too.<\/strong><\/p>\n

Whether it’s the dark, suffocating deep sea or the scalding, bubbling thermal pools, life finds a way to call it home. So, it isn’t a surprise that\u00a0fish living in the freezing cold waters of the Arctic and Antarctic<\/a>\u00a0could provide the inspiration for a new generation of cryoprotectant molecules.<\/p>\n

The fish, and other cold-temperature extremophiles, produce proteins that can recognise and bind to ice as it is forming, acting like an anti-freeze. Ice crystals can do a lot of damage to the body, from causing proteins to clump together to weakening the structures that hold tissue together.<\/p>\n

This led Professor Matthew Gibson, at Warwick University in the United Kingdom, to attempt to recreate the abilities of ice-binding proteins using synthetic polymers. These have the advantage of being easier to adjust or \u2018tune\u2019 to suit their purpose and to manufacture at scale.<\/p>\n

\u2018We can make it a bit more tuneable as you’ve got literally thousands of different monomers you could use to make a polymer,\u2019 he said. \u2018Our aim was, if we can mimic some of those properties, to apply these to improve or change how we freeze cells.\u2019<\/p>\n

Through the\u00a0CRYOSTEM<\/a>\u00a0project, Prof. Gibson tested these polymers by adding them to samples of bone marrow stem cells, which are often frozen when being transported for a transplant. The current system involves adding solvents to protect the cells when freezing. However, it isn’t ideal. A significant proportion of the cells do not survive and the solvent itself can affect them.<\/p>\n

Prof. Gibson has been able to show that his\u00a0polymers can decrease the amount of solvent<\/a>\u00a0needed for cryopreservation, reducing the damage done to the cells. This approach could also help biomedical research, allowing scientists to more reliably store and thaw a wider range of cells in the laboratory.<\/p>\n

He is now expanding this work through the\u00a0ICE PACK<\/a>\u00a0project to apply cryoprotectant polymers to the growing field of biologic treatments. Traditional pharmaceuticals are typically small molecules that can be put into a tablet form and will be stable in the medicine cabinet for months. Now, more and more of the modern best-selling drugs are proteins, such as antibodies to treat arthritis or cancer, which need to be stored much more carefully.<\/p>\n

More delicate still are cell-based therapies like CAR T cells, which are modified immune cells used to treat cancer. At the moment, cell-based therapies are rare and very expensive, but in the future, they may become more common.<\/p>\n

\u2018They have quite a complex process, where they’re collected from the donor and then they need modifying, freezing and shipping,\u2019 said Prof. Gibson. \u2018Anything you can do to make sure they’re protected as best as they can, or make the cold chain easier, is going to have a really big (effect on) patient outcome.\u2019<\/p>\n

The ultimate dream<\/strong><\/p>\n

Zoom out from individual proteins or cells and the picture becomes even more complicated.<\/p>\n

\u2018Ice can form inside and outside the cell. Depending on where the ice forms, it is disruptive to cellular structures or extra-cellular structures \u2013 for example, the extra-cellular matrix in which the cells are embedded,\u2019 said Professor Ilja Voets at Eindhoven University of Technology in the Netherlands.<\/p>\n

The challenge of freezing samples of tissue is another area where analogues of ice-binding proteins could help. As part of the\u00a0PROTECT<\/a>\u00a0project, Prof. Voets is particularly interested in the freezing and thawing of heart cells and tissue. Currently, only about half of the cells are useable after freezing when studying cultures in the laboratory. This becomes even more difficult when studying tissue samples.<\/p>\n

\u2018Typically, the preservation conditions are optimal for one cell type (within the heart tissue), but not for the other types, or not for the tissue as a whole,\u2019 she said. It is a big challenge but the ice-binding protein analogues don\u2019t have to preserve the tissue perfectly to be useful. \u2018There’s a very strong regenerative ability of tissues. So in some cases, if the damage is modest, then the tissue can repair itself and it can still be used.\u2019<\/p>\n

Voets is using very high-resolution microscopy to understand how different types of ice-binding protein analogues are able to prevent ice formation. This will help to create improved versions that can reduce freeze injury to tissue.<\/p>\n

The potential to reliably bank your own tissue samples, to be thawed if needed in the future, is \u2018one of the ultimate dreams\u2019, Voets said.<\/p>\n

\u2018Say someone has an infarct (a region of dead cells), you will be able to transplant heart tissue from that very specific patient because you have banked it. That’ll be fantastic, and it could lower the risk of rejection as well. There’s a lot of things that we could gain from being able to bank more types of cells and tissues.\u2019<\/p>\n

 <\/p>\n

\u2018Our cultural imagery of frozenness is about to change.\u2019<\/strong><\/i><\/p>\n

Prof. Thomas Lemke, Goethe University, Germany<\/strong><\/i><\/p><\/blockquote>\n

 <\/p>\n

A technological fix<\/strong><\/p>\n

Advances in cryopreservation are already making an impact on society. Some companies, mostly in the US, offer egg-freezing services as a perk to employees who want to delay having a child. This essentially defers the decision-making of how to align the competing needs of professional advancement and childcare, says Professor Thomas Lemke, from Goethe University in Germany. \u2018This is what is often called a technological fix for a societal problem,\u2019 he said.<\/p>\n

This technological fix places further burden on the individual to adapt so that society doesn’t need to change. Prof. Lemke said there is a real danger that it could become a societal expectation. Cryopreservation could become the ultimate insurance policy. Private companies already offer banking for umbilical cord blood, which is rich in stem cells. Perhaps in the future, we will also be able to bank heart tissue.<\/p>\n

Prof. Lemke is studying the societal impacts of this ‘suspended life’, as he calls it, across Europe through the\u00a0CRYOSOCIETIES<\/a>\u00a0project. He is examining how cryopreservation practices have developed and how they influence our decision-making.<\/p>\n

Whereas societies have often associated coldness with death, cryopreservation creates new opportunities from medical care to biodiversity.<\/p>\n

\u2018It’s no longer the state of non-transformation, of remaining inert. But rather, it mobilises things and it opens up options,\u2019 said Prof. Lemke. \u2018Our cultural imagery of frozenness is about to change.\u2019<\/p>\n

The research in this article was funded by the EU\u2019s European Research Council. If you liked this article, please consider sharing it on social media.<\/i><\/p>\n

Originally published on Horizon Magazine<\/a><\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

The idea of cryogenically freezing a person to preserve their body until many years into the future has long been a staple of science fiction stories. However, the need to reliably store biological materials such as cells or tissue is a common concern for scientific research and, increasingly, for society too. Whether it’s the dark, … Read more<\/a><\/p>\n","protected":false},"author":298,"featured_media":1781,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"generate_page_header":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[12,16],"tags":[449,448,28],"class_list":["post-1780","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health","category-technology","tag-biology","tag-human","tag-technology"],"yoast_head":"\nAntifreeze fish inspire new cryoprotectants for human cells and tissues - Horizon Magazine Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/scienceblog.com\/horizon\/1780\/antifreeze-fish-inspire-new-cryoprotectants-for-human-cells-and-tissues\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Antifreeze fish inspire new cryoprotectants for human cells and tissues\" \/>\n<meta property=\"og:description\" content=\"The idea of cryogenically freezing a person to preserve their body until many years into the future has long been a staple of science fiction stories. However, the need to reliably store biological materials such as cells or tissue is a common concern for scientific research and, increasingly, for society too. Whether it’s the dark, ... Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/scienceblog.com\/horizon\/1780\/antifreeze-fish-inspire-new-cryoprotectants-for-human-cells-and-tissues\/\" \/>\n<meta property=\"og:site_name\" content=\"Horizon Magazine Blog\" \/>\n<meta property=\"article:author\" content=\"https:\/\/www.facebook.com\/horizon.magazine.eu\" \/>\n<meta property=\"article:published_time\" content=\"2021-08-10T05:55:40+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2021\/08\/ANTIFREEZE-image1-CMS-aa09260a-scaled.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2560\" \/>\n\t<meta property=\"og:image:height\" content=\"1706\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Horizon Magazine\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@https:\/\/twitter.com\/HorizonMagEU\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Horizon Magazine\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"6 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/1780\\\/antifreeze-fish-inspire-new-cryoprotectants-for-human-cells-and-tissues\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/1780\\\/antifreeze-fish-inspire-new-cryoprotectants-for-human-cells-and-tissues\\\/\"},\"author\":{\"name\":\"Horizon Magazine\",\"@id\":\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/#\\\/schema\\\/person\\\/8f23522ba58f477f04dd574e1034f679\"},\"headline\":\"Antifreeze fish inspire new cryoprotectants for human cells and tissues\",\"datePublished\":\"2021-08-10T05:55:40+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/1780\\\/antifreeze-fish-inspire-new-cryoprotectants-for-human-cells-and-tissues\\\/\"},\"wordCount\":1139,\"publisher\":{\"@id\":\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/1780\\\/antifreeze-fish-inspire-new-cryoprotectants-for-human-cells-and-tissues\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/wp-content\\\/uploads\\\/sites\\\/4\\\/2021\\\/08\\\/ANTIFREEZE-image1-CMS-aa09260a-scaled.jpg\",\"keywords\":[\"biology\",\"human\",\"technology\"],\"articleSection\":[\"Health\",\"Technology\"],\"inLanguage\":\"en-US\",\"copyrightYear\":\"2021\",\"copyrightHolder\":{\"@id\":\"https:\\\/\\\/scienceblog.com\\\/#organization\"}},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/1780\\\/antifreeze-fish-inspire-new-cryoprotectants-for-human-cells-and-tissues\\\/\",\"url\":\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/1780\\\/antifreeze-fish-inspire-new-cryoprotectants-for-human-cells-and-tissues\\\/\",\"name\":\"Antifreeze fish inspire new cryoprotectants for human cells and tissues - Horizon Magazine Blog\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/1780\\\/antifreeze-fish-inspire-new-cryoprotectants-for-human-cells-and-tissues\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/1780\\\/antifreeze-fish-inspire-new-cryoprotectants-for-human-cells-and-tissues\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/wp-content\\\/uploads\\\/sites\\\/4\\\/2021\\\/08\\\/ANTIFREEZE-image1-CMS-aa09260a-scaled.jpg\",\"datePublished\":\"2021-08-10T05:55:40+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/1780\\\/antifreeze-fish-inspire-new-cryoprotectants-for-human-cells-and-tissues\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/1780\\\/antifreeze-fish-inspire-new-cryoprotectants-for-human-cells-and-tissues\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/1780\\\/antifreeze-fish-inspire-new-cryoprotectants-for-human-cells-and-tissues\\\/#primaryimage\",\"url\":\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/wp-content\\\/uploads\\\/sites\\\/4\\\/2021\\\/08\\\/ANTIFREEZE-image1-CMS-aa09260a-scaled.jpg\",\"contentUrl\":\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/wp-content\\\/uploads\\\/sites\\\/4\\\/2021\\\/08\\\/ANTIFREEZE-image1-CMS-aa09260a-scaled.jpg\",\"width\":2560,\"height\":1706,\"caption\":\"Test tube in liquid nitrogen, cryopreservation process\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/1780\\\/antifreeze-fish-inspire-new-cryoprotectants-for-human-cells-and-tissues\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Antifreeze fish inspire new cryoprotectants for human cells and tissues\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/#website\",\"url\":\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/\",\"name\":\"Horizon Magazine Blog\",\"description\":\"The EU Research & Innovation Magazine\",\"publisher\":{\"@id\":\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/#organization\",\"name\":\"Horizon Magazine Blog\",\"url\":\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/wp-content\\\/uploads\\\/sites\\\/4\\\/2026\\\/04\\\/eu-logo.jpg\",\"contentUrl\":\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/wp-content\\\/uploads\\\/sites\\\/4\\\/2026\\\/04\\\/eu-logo.jpg\",\"width\":601,\"height\":283,\"caption\":\"Horizon Magazine Blog\"},\"image\":{\"@id\":\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/#\\\/schema\\\/logo\\\/image\\\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/#\\\/schema\\\/person\\\/8f23522ba58f477f04dd574e1034f679\",\"name\":\"Horizon Magazine\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/407bd816be829798850d5e7f646c4137f70c86c6af6c761b67a6ea80c364ffa4?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/407bd816be829798850d5e7f646c4137f70c86c6af6c761b67a6ea80c364ffa4?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/407bd816be829798850d5e7f646c4137f70c86c6af6c761b67a6ea80c364ffa4?s=96&d=mm&r=g\",\"caption\":\"Horizon Magazine\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/horizon.magazine.eu\",\"https:\\\/\\\/x.com\\\/https:\\\/\\\/twitter.com\\\/HorizonMagEU\"],\"url\":\"https:\\\/\\\/scienceblog.com\\\/horizon\\\/author\\\/horizonmagazine\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Antifreeze fish inspire new cryoprotectants for human cells and tissues - Horizon Magazine Blog","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/scienceblog.com\/horizon\/1780\/antifreeze-fish-inspire-new-cryoprotectants-for-human-cells-and-tissues\/","og_locale":"en_US","og_type":"article","og_title":"Antifreeze fish inspire new cryoprotectants for human cells and tissues","og_description":"The idea of cryogenically freezing a person to preserve their body until many years into the future has long been a staple of science fiction stories. However, the need to reliably store biological materials such as cells or tissue is a common concern for scientific research and, increasingly, for society too. Whether it’s the dark, ... Read more","og_url":"https:\/\/scienceblog.com\/horizon\/1780\/antifreeze-fish-inspire-new-cryoprotectants-for-human-cells-and-tissues\/","og_site_name":"Horizon Magazine Blog","article_author":"https:\/\/www.facebook.com\/horizon.magazine.eu","article_published_time":"2021-08-10T05:55:40+00:00","og_image":[{"width":2560,"height":1706,"url":"https:\/\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2021\/08\/ANTIFREEZE-image1-CMS-aa09260a-scaled.jpg","type":"image\/jpeg"}],"author":"Horizon Magazine","twitter_card":"summary_large_image","twitter_creator":"@https:\/\/twitter.com\/HorizonMagEU","twitter_misc":{"Written by":"Horizon Magazine","Est. reading time":"6 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/scienceblog.com\/horizon\/1780\/antifreeze-fish-inspire-new-cryoprotectants-for-human-cells-and-tissues\/#article","isPartOf":{"@id":"https:\/\/scienceblog.com\/horizon\/1780\/antifreeze-fish-inspire-new-cryoprotectants-for-human-cells-and-tissues\/"},"author":{"name":"Horizon Magazine","@id":"https:\/\/scienceblog.com\/horizon\/#\/schema\/person\/8f23522ba58f477f04dd574e1034f679"},"headline":"Antifreeze fish inspire new cryoprotectants for human cells and tissues","datePublished":"2021-08-10T05:55:40+00:00","mainEntityOfPage":{"@id":"https:\/\/scienceblog.com\/horizon\/1780\/antifreeze-fish-inspire-new-cryoprotectants-for-human-cells-and-tissues\/"},"wordCount":1139,"publisher":{"@id":"https:\/\/scienceblog.com\/horizon\/#organization"},"image":{"@id":"https:\/\/scienceblog.com\/horizon\/1780\/antifreeze-fish-inspire-new-cryoprotectants-for-human-cells-and-tissues\/#primaryimage"},"thumbnailUrl":"https:\/\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2021\/08\/ANTIFREEZE-image1-CMS-aa09260a-scaled.jpg","keywords":["biology","human","technology"],"articleSection":["Health","Technology"],"inLanguage":"en-US","copyrightYear":"2021","copyrightHolder":{"@id":"https:\/\/scienceblog.com\/#organization"}},{"@type":"WebPage","@id":"https:\/\/scienceblog.com\/horizon\/1780\/antifreeze-fish-inspire-new-cryoprotectants-for-human-cells-and-tissues\/","url":"https:\/\/scienceblog.com\/horizon\/1780\/antifreeze-fish-inspire-new-cryoprotectants-for-human-cells-and-tissues\/","name":"Antifreeze fish inspire new cryoprotectants for human cells and tissues - Horizon Magazine Blog","isPartOf":{"@id":"https:\/\/scienceblog.com\/horizon\/#website"},"primaryImageOfPage":{"@id":"https:\/\/scienceblog.com\/horizon\/1780\/antifreeze-fish-inspire-new-cryoprotectants-for-human-cells-and-tissues\/#primaryimage"},"image":{"@id":"https:\/\/scienceblog.com\/horizon\/1780\/antifreeze-fish-inspire-new-cryoprotectants-for-human-cells-and-tissues\/#primaryimage"},"thumbnailUrl":"https:\/\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2021\/08\/ANTIFREEZE-image1-CMS-aa09260a-scaled.jpg","datePublished":"2021-08-10T05:55:40+00:00","breadcrumb":{"@id":"https:\/\/scienceblog.com\/horizon\/1780\/antifreeze-fish-inspire-new-cryoprotectants-for-human-cells-and-tissues\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/scienceblog.com\/horizon\/1780\/antifreeze-fish-inspire-new-cryoprotectants-for-human-cells-and-tissues\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/scienceblog.com\/horizon\/1780\/antifreeze-fish-inspire-new-cryoprotectants-for-human-cells-and-tissues\/#primaryimage","url":"https:\/\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2021\/08\/ANTIFREEZE-image1-CMS-aa09260a-scaled.jpg","contentUrl":"https:\/\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2021\/08\/ANTIFREEZE-image1-CMS-aa09260a-scaled.jpg","width":2560,"height":1706,"caption":"Test tube in liquid nitrogen, cryopreservation process"},{"@type":"BreadcrumbList","@id":"https:\/\/scienceblog.com\/horizon\/1780\/antifreeze-fish-inspire-new-cryoprotectants-for-human-cells-and-tissues\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/scienceblog.com\/horizon\/"},{"@type":"ListItem","position":2,"name":"Antifreeze fish inspire new cryoprotectants for human cells and tissues"}]},{"@type":"WebSite","@id":"https:\/\/scienceblog.com\/horizon\/#website","url":"https:\/\/scienceblog.com\/horizon\/","name":"Horizon Magazine Blog","description":"The EU Research & Innovation Magazine","publisher":{"@id":"https:\/\/scienceblog.com\/horizon\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/scienceblog.com\/horizon\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/scienceblog.com\/horizon\/#organization","name":"Horizon Magazine Blog","url":"https:\/\/scienceblog.com\/horizon\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/scienceblog.com\/horizon\/#\/schema\/logo\/image\/","url":"https:\/\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2026\/04\/eu-logo.jpg","contentUrl":"https:\/\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2026\/04\/eu-logo.jpg","width":601,"height":283,"caption":"Horizon Magazine Blog"},"image":{"@id":"https:\/\/scienceblog.com\/horizon\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/scienceblog.com\/horizon\/#\/schema\/person\/8f23522ba58f477f04dd574e1034f679","name":"Horizon Magazine","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/407bd816be829798850d5e7f646c4137f70c86c6af6c761b67a6ea80c364ffa4?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/407bd816be829798850d5e7f646c4137f70c86c6af6c761b67a6ea80c364ffa4?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/407bd816be829798850d5e7f646c4137f70c86c6af6c761b67a6ea80c364ffa4?s=96&d=mm&r=g","caption":"Horizon Magazine"},"sameAs":["https:\/\/www.facebook.com\/horizon.magazine.eu","https:\/\/x.com\/https:\/\/twitter.com\/HorizonMagEU"],"url":"https:\/\/scienceblog.com\/horizon\/author\/horizonmagazine\/"}]}},"jetpack_featured_media_url":"https:\/\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2021\/08\/ANTIFREEZE-image1-CMS-aa09260a-scaled.jpg","jetpack_shortlink":"https:\/\/wp.me\/pgtNKV-sI","jetpack_sharing_enabled":true,"jetpack-related-posts":[{"id":1940,"url":"https:\/\/scienceblog.com\/horizon\/1940\/antifreeze-fish-inspire-new-cryoprotectants-for-human-cells-and-tissues-2\/","url_meta":{"origin":1780,"position":0},"title":"Antifreeze fish inspire new cryoprotectants for human cells and tissues","author":"Horizon Magazine","date":"January 18, 2022","format":false,"excerpt":"The idea of cryogenically freezing a person to preserve their body until many years into the future has long been a staple of science fiction stories. However, the need to reliably store biological materials such as cells or tissue is a common concern for scientific research and, increasingly, for society\u2026","rel":"","context":"In "Health"","block_context":{"text":"Health","link":"https:\/\/scienceblog.com\/horizon\/category\/health\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2022\/01\/aa09260a.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2022\/01\/aa09260a.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2022\/01\/aa09260a.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2022\/01\/aa09260a.jpg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2022\/01\/aa09260a.jpg?resize=1050%2C600&ssl=1 3x"},"classes":[]},{"id":1782,"url":"https:\/\/scienceblog.com\/horizon\/1782\/cooling-without-warming\/","url_meta":{"origin":1780,"position":1},"title":"Cooling without warming","author":"Horizon Magazine","date":"August 10, 2021","format":false,"excerpt":"Demand for energy-intensive cooling technologies - whether for buildings, electronics, or refrigeration of food and medicines - is on the rise as global temperatures increase. But how can we make cooling technologies available to all while reducing the environmental impact? In August, Horizon looks at how science and innovation can\u2026","rel":"","context":"In "Earth, Energy & Environment"","block_context":{"text":"Earth, Energy & Environment","link":"https:\/\/scienceblog.com\/horizon\/category\/earth-energy-environment\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2021\/08\/Cooling-without-warming-intro-to-MF-_-sergei-akulich-hfbfc5ymick-unsplash-scaled.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2021\/08\/Cooling-without-warming-intro-to-MF-_-sergei-akulich-hfbfc5ymick-unsplash-scaled.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2021\/08\/Cooling-without-warming-intro-to-MF-_-sergei-akulich-hfbfc5ymick-unsplash-scaled.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2021\/08\/Cooling-without-warming-intro-to-MF-_-sergei-akulich-hfbfc5ymick-unsplash-scaled.jpg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2021\/08\/Cooling-without-warming-intro-to-MF-_-sergei-akulich-hfbfc5ymick-unsplash-scaled.jpg?resize=1050%2C600&ssl=1 3x, https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2021\/08\/Cooling-without-warming-intro-to-MF-_-sergei-akulich-hfbfc5ymick-unsplash-scaled.jpg?resize=1400%2C800&ssl=1 4x"},"classes":[]},{"id":1461,"url":"https:\/\/scienceblog.com\/horizon\/1461\/secret-of-how-fish-repair-their-hearts-could-help-cardiac-patients\/","url_meta":{"origin":1780,"position":2},"title":"Secret of how fish repair their hearts could help cardiac patients","author":"Anthony King","date":"September 29, 2020","format":false,"excerpt":"The ability of certain fish to heal damage to their hearts could lead to new treatments for patients who have suffered heart attacks and may also help to unravel how the lifestyle of our parents and grandparents can affect our own heart health. The human heart cannot heal itself. After\u2026","rel":"","context":"In "Health"","block_context":{"text":"Health","link":"https:\/\/scienceblog.com\/horizon\/category\/health\/"},"img":{"alt_text":"The Mexican Tetra cave fish is brighter and has more sensitive taste buds than fish of the same species that live in rivers, but unlike those, it cannot regenerate heart muscle. Image credit - H.Zell\/Wikimedia Commons, licensed under CC BY 3.0","src":"https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2020\/09\/2048px-Astyanax_mexicanus_01.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2020\/09\/2048px-Astyanax_mexicanus_01.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2020\/09\/2048px-Astyanax_mexicanus_01.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2020\/09\/2048px-Astyanax_mexicanus_01.jpg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2020\/09\/2048px-Astyanax_mexicanus_01.jpg?resize=1050%2C600&ssl=1 3x, https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2020\/09\/2048px-Astyanax_mexicanus_01.jpg?resize=1400%2C800&ssl=1 4x"},"classes":[]},{"id":2834,"url":"https:\/\/scienceblog.com\/horizon\/2834\/3d-printed-living-cells-pave-way-for-tomorrows-medicine-and-cruelty-free-animal-products\/","url_meta":{"origin":1780,"position":3},"title":"3D-printed living cells pave way for tomorrow’s medicine and cruelty-free animal products","author":"Horizon Magazine","date":"August 23, 2024","format":false,"excerpt":"EU-funded researchers are expanding the possibilities of 3D printing to create miniature human organs and a variety of products made from living tissue, including food. By Tereza Pultarova 3D printing has come a long way since its early days in the 1980s and is considered an essential tool in many\u2026","rel":"","context":"In "Health"","block_context":{"text":"Health","link":"https:\/\/scienceblog.com\/horizon\/category\/health\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2024\/08\/23.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2024\/08\/23.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2024\/08\/23.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2024\/08\/23.jpg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2024\/08\/23.jpg?resize=1050%2C600&ssl=1 3x, https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2024\/08\/23.jpg?resize=1400%2C800&ssl=1 4x"},"classes":[]},{"id":227,"url":"https:\/\/scienceblog.com\/horizon\/227\/lab-grown-tissues-to-improve-reliability-of-safety-tests-for-drugs-chemicals\/","url_meta":{"origin":1780,"position":4},"title":"Lab-grown tissues to improve reliability of safety tests for drugs, chemicals","author":"Horizon Magazine","date":"April 11, 2018","format":false,"excerpt":"by Natalie Grover Testing the safety of medicines and chemicals on organ-like structures developed from various types of stem cells could reduce the reliance on animal testing and streamline chemical and drug development, according to scientists in the Netherlands who are in the early stages of developing such technology.\u00a0 Tissues\u2026","rel":"","context":"In "Health"","block_context":{"text":"Health","link":"https:\/\/scienceblog.com\/horizon\/category\/health\/"},"img":{"alt_text":"This human liver organoid gives researchers hope that animal-based studies about drug safety will be a method of the past one day.","src":"https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2018\/04\/Organoid.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2018\/04\/Organoid.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2018\/04\/Organoid.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2018\/04\/Organoid.jpg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2018\/04\/Organoid.jpg?resize=1050%2C600&ssl=1 3x, https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2018\/04\/Organoid.jpg?resize=1400%2C800&ssl=1 4x"},"classes":[]},{"id":1415,"url":"https:\/\/scienceblog.com\/horizon\/1415\/hydroacoustic-3d-snapshots-of-fish-habitats-could-help-stem-overfishing\/","url_meta":{"origin":1780,"position":5},"title":"Hydroacoustic 3D snapshots of fish habitats could help stem overfishing","author":"Steve Gillman","date":"August 31, 2020","format":false,"excerpt":"Robotic eyes and ears under the water\u2019s surface could help researchers figure out how much fish are in our oceans \u2013 and how much we can eat. Researchers are hoping fishing nets scanned by high resolution sonar, underwater cameras and unmanned aquatic vehicles can help paint one of the most\u2026","rel":"","context":"In "Earth, Energy & Environment"","block_context":{"text":"Earth, Energy & Environment","link":"https:\/\/scienceblog.com\/horizon\/category\/earth-energy-environment\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2020\/08\/fishingnorthsea.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2020\/08\/fishingnorthsea.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2020\/08\/fishingnorthsea.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2020\/08\/fishingnorthsea.jpg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2020\/08\/fishingnorthsea.jpg?resize=1050%2C600&ssl=1 3x"},"classes":[]}],"_links":{"self":[{"href":"https:\/\/scienceblog.com\/horizon\/wp-json\/wp\/v2\/posts\/1780","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/scienceblog.com\/horizon\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/scienceblog.com\/horizon\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/scienceblog.com\/horizon\/wp-json\/wp\/v2\/users\/298"}],"replies":[{"embeddable":true,"href":"https:\/\/scienceblog.com\/horizon\/wp-json\/wp\/v2\/comments?post=1780"}],"version-history":[{"count":0,"href":"https:\/\/scienceblog.com\/horizon\/wp-json\/wp\/v2\/posts\/1780\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/scienceblog.com\/horizon\/wp-json\/wp\/v2\/media\/1781"}],"wp:attachment":[{"href":"https:\/\/scienceblog.com\/horizon\/wp-json\/wp\/v2\/media?parent=1780"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/scienceblog.com\/horizon\/wp-json\/wp\/v2\/categories?post=1780"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/scienceblog.com\/horizon\/wp-json\/wp\/v2\/tags?post=1780"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}