{"id":1871,"date":"2021-11-11T09:37:17","date_gmt":"2021-11-11T09:37:17","guid":{"rendered":"https:\/\/horizon.peachpuff-wolverine-566518.hostingersite.com\/?p=1871"},"modified":"2021-11-11T09:37:17","modified_gmt":"2021-11-11T09:37:17","slug":"blood-cancer-diagnosis-when-mission-impossible-became-possible","status":"publish","type":"post","link":"https:\/\/scienceblog.com\/horizon\/1871\/blood-cancer-diagnosis-when-mission-impossible-became-possible\/","title":{"rendered":"Blood cancer diagnosis: when mission impossible became possible"},"content":{"rendered":"

Great achievements in science don\u2019t just happen \u2013 they\u2019re created. This is the story of how a formidable research alliance was born and how it resulted in a discovery that would forever transform the diagnosis and treatment of blood and bone marrow cancers.\u00a0<\/strong><\/p>\n

 <\/p>\n

The EU has an ambitious goal: under its Mission on Cancer<\/a>, \u201cBy 2030, more than 3 million lives saved, living longer and better\u201d. According to the WHO<\/a>, there were around 320,00 new cases of people with blood cancer in Europe in 2020.<\/p>\n

Once deemed impossible, as well as exclusively expert based, standardisation of blood collection and processing for blood cancer diagnostics use is now considered imperative.<\/p>\n

This is the result of decades-long work carried out by three groups under an umbrella organisation formed in 2009, the European Scientific foundation for Laboratory Hemato Oncology (ESLHO<\/a>). In order of conception, they are EuroClonality (1996), EuroMRD (2001) and EuroFlow <\/a>(2006).<\/p>\n

Both EuroClonality and EuroMRD worked on the DNA and genes of leukaemia cells. EuroFlow refined how we look at each individual cell and take crucial measurements important for disease diagnosis, a process called flow cytometry.<\/p>\n

Pooling their knowledge and resources, the three groups organised standardised lab methods to diagnose the three blood and bone marrow cancers: leukaemia, lymphoma and myeloma.<\/p>\n

\u2018The core of our success is standardisation,\u2019 said Jacques van Dongen, professor of medical immunology at the LUMC. \u2018Wherever the patient is in the world, their diagnostic lab is using the same reagents and procedures as advised by EuroFlow.\u2019<\/p>\n

Professor van Dongen is certain about the reason for their success. This level of standardisation has not been achieved earlier with assays of such high complexity. All this could never have been achieved without EU funding and support.\u2019<\/p>\n

More labs, more patients, more data<\/strong><\/p>\n

As Euroflow methods spread globally, more labs and patients mean more data, and standardisation is crucial. Making sure diagnostic data is the same anywhere in the world is the most important factor for rapid diagnosis.<\/p>\n

\u2018Analysing this data with big data tools leads to further refinement and categorisation of the individual\u2019s disease status. This stratification of the patients ultimately means more personalised treatment,\u2019 noted Professor van Dongen.<\/p>\n

When many labs use flow cytometry to look at the physical characteristics of each cell, \u00a0a host of variables can be introduced. But standardisation means every diagnostic centre is using the same criteria so this doesn\u2019t interfere with accuracy of diagnosis.<\/p>\n

Counting cells at the speed of light<\/strong><\/p>\n

Today\u2019s labs can count and categorise blood cells at phenomenal speed for rapid diagnosis.<\/p>\n

\u2018There can be 10 million leucocytes, a type of white blood cell, in 2 ml of blood,\u2019 Professor van Dongen explained. \u2018Using the most up-to-date flow cytometry machines, we can measure 10 million cells in 8 minutes with a 1 in a 100,000 sensitivity. That is, 1 leukaemia cell can be distinguished individually from a population of 100,000 normal cells.\u2019<\/p>\n

This was not always the case. For instance, back in 1996 when Anton Langerak, now professor at Leiden University, South Holland, was just embarking on his postdoc in diagnostics for leukaemia and lymphoma under the EU programme BIOMED-2<\/a>. Now known as EuroClonality<\/a>, this programme was then focused on amplifying and multiplying small amounts of genetic material, DNA or RNA, using the polymerase chain reaction (PCR), then only just discovered.<\/p>\n

Looking for specific molecules and genes is a huge advance on the early days, when leukaemias were characterised on the basis of chromosomes only. Looking at types of chromosomes gives a less accurate diagnosis as one chromosome can contain thousands of genes.<\/p>\n

\u2018The added value of PCR for the patient could be confirmation of a new tumour, and this is essential for treatment determination. At the start of my research career, there was no standardised PCR test for lymphoma. Moreover, patients were faced with a long wait for results of the blood tests, around a month,\u2019 Professor Langerak recalled. Nowadays, they have their test results within a day.<\/p>\n

On November 11 and 12, all three groups \u2013 Euroflow, EuroClonality and EuroMRD \u2013 will meet in Leiden for the 10th ESLHO Symposium<\/a>. For Professor van Dongen, who chairs the ESLHO board, this year\u2019s symposium is of particular importance because it coincides with the 25th anniversary of the inception of EuroFlow.\u00a0<\/em><\/p>\n

 <\/p>\n

\n
More info<\/div>\n
\n

EuroFlow<\/a><\/p>\n

BIOMED-2<\/a><\/p>\n

EuroClonality<\/a><\/p>\n

ESLHO<\/a><\/p>\n

EU Mission on Cancer<\/a><\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Great achievements in science don\u2019t just happen \u2013 they\u2019re created. This is the story of how a formidable research alliance was born and how it resulted in a discovery that would forever transform the diagnosis and treatment of blood and bone marrow cancers.\u00a0   The EU has an ambitious goal: under its Mission on Cancer, … Read more<\/a><\/p>\n","protected":false},"author":298,"featured_media":1872,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"generate_page_header":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[12],"tags":[],"class_list":["post-1871","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health"],"yoast_head":"\nBlood cancer diagnosis: when mission impossible became possible - Horizon Magazine Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/scienceblog.com\/horizon\/1871\/blood-cancer-diagnosis-when-mission-impossible-became-possible\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Blood cancer diagnosis: when mission impossible became possible\" \/>\n<meta property=\"og:description\" content=\"Great achievements in science don\u2019t just happen \u2013 they\u2019re created. 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By\u00a0\u00a0ANTHONY KING At a hotel in the Scottish city of Aberdeen about 20 years ago, urologist James N\u2019Dow and other doctors met a group\u2026","rel":"","context":"In "Health"","block_context":{"text":"Health","link":"https:\/\/scienceblog.com\/horizon\/category\/health\/"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":2508,"url":"https:\/\/scienceblog.com\/horizon\/2508\/young-cancer-survivors-in-europe-get-increased-post-cure-help\/","url_meta":{"origin":1871,"position":3},"title":"Young cancer survivors in Europe get increased post-cure help","author":"Horizon Magazine","date":"September 25, 2023","format":false,"excerpt":"As medical advances in oncology enable more patients to beat tumours, greater attention is being paid to secondary effects from treatment. 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