{"id":2194,"date":"2022-10-29T05:40:52","date_gmt":"2022-10-29T05:40:52","guid":{"rendered":"https:\/\/horizon.peachpuff-wolverine-566518.hostingersite.com\/?p=2194"},"modified":"2022-10-29T05:40:52","modified_gmt":"2022-10-29T05:40:52","slug":"repurposing-finds-new-health-giving-uses-for-old-medicines","status":"publish","type":"post","link":"https:\/\/scienceblog.com\/horizon\/2194\/repurposing-finds-new-health-giving-uses-for-old-medicines\/","title":{"rendered":"Repurposing finds new health-giving uses for old medicines"},"content":{"rendered":"

Medicines that have been approved to medicate one ailment are being repurposed to treat others, saving lives and giving fresh hope to millions saddled with disease.<\/p>\n

By<\/em><\/strong>\u00a0\u00a0VITTORIA D\u2019ALESSIO<\/p>\n

Drug discovery is slow, expensive and often ends in failure, so no wonder scientists are exploring new ways to medicate disease. One source of hope lies in \u2018drug repurposing\u2019, where new uses are found for established medicines.<\/p>\n

For example, the humble dexamethasone proved a lifesaver during the Covid-19 pandemic, significantly reducing mortality in critical patients who are put on oxygen or ventilators.<\/p>\n

Yet the drug was not developed with a killer virus in mind. Dexamethasone became a licenced medication half a century before the advent of Covid-19, and it was designed to help patients with swelling and severe allergies. The serendipitous discovery that it also kept people alive during the coronavirus pandemic was the result of the scientists working at lightening-speed in the field of \u201cdrug repurposing\u201d.<\/p>\n

Drug repurposing is not just some niche area of scientific exploration. Finding new uses for pre-existing medicines is becoming a major focus for research bodies the world over, with Europe leading the way.<\/p>\n

Drug discovery<\/strong><\/p>\n

\u2018We\u2019ll still need to discover new drugs, but drug repurposing is going to play a growing role in medicine, and it\u2019s going to be particularly important in the area of rare diseases,\u2019 said Anton Ussi, coordinator of the recently launched, \u20ac22.6m\u00a0Horizon-funded REMEDI4ALL project<\/a>. \u2018It could make the difference between having no drugs to treat a debilitating condition to having a repurposed one that has a big impact on quality of life.\u2019<\/p>\n

There are clear benefits to repurposing \u2018old\u2019 drugs to tackle diseases for which treatment is lacking. Developing a drug from scratch is a huge undertaking. The average cost is over \u20ac1 billion, and typically it takes more than decade for a new medicine to complete its journey from initial discovery through clinical trials and to the marketplace. What\u2019s more, many therapeutic molecules that look promising near the start of the research process are eventually ditched because they\u2019re found to be either ineffective or unsafe.<\/p>\n

\u2018By turning our attention to an existing drug, in optimal circumstances, a new treatment can be found in just a few years and for a fraction of the cost \u2013 rather than many years of research and tens of millions, even hundreds of millions, of euro,\u2019 said Mr Ussi, who is based at\u00a0EATRIS, the European infrastructure for translational medicine<\/a>.<\/p>\n

Many steps<\/strong><\/p>\n

Drug repurposing may bring efficiencies to drug development, but many steps still stand between a researcher\u2019s light-bulb idea and a boxed medicine. Clinical trials are needed to establish a medicine\u2019s effectiveness at treating the new condition. The drug must be deemed safe for its new application. Dosage protocols must be established. Patient advocacy groups must be consulted. Regulatory authorities must be satisfied. A manufacturer and distributor must be found.<\/p>\n

However, patchy coordination between academics and institutions working in the field is stymying progress. Teams are working on their projects in silos and expertise is going untapped. As a result, many researchers working on a promising idea simply give up.<\/p>\n

Elaborating, Mr Ussi said, \u2018There are islands of great research activity but it\u2019s difficult to take your research to the end without outside professional help.<\/p>\n

\u2018Take the example of an expert clinician who knows anecdotally that a drug used off-label (for an unapproved purpose) slows down a disease,\u2019 he said. \u2018This clinician may want to validate their hunch so the drug can become authorised to treat that disease, but they don\u2019t have access to the broad range of experts and disciplines needed to do so. Because of this, most would-be drug developers run out of capacity.\u2019<\/p>\n

The aim of REMEDI4ALL is to catch enthusiastic researchers and research groups before they fall. \u2018We want to make the world of drug repurposing more understandable,\u2019 said Mr Ussi. \u2018We\u2019re creating development teams that can get to grips with the specific requirements of a project and help move the process along to completion.\u2019<\/p>\n

Through its \u2018transparent and predictable pipeline\u2019, REMEDI4ALL will bring experts in all areas of drug development from all over the world into one space.<\/p>\n

Repurposing process<\/strong><\/p>\n

\u2018Everyone who has a role in the repurposing process will become part of our network,\u2019 said Mr Ussi. \u2018Our vibrant community will be able to help researchers execute their projects at any phase of development. Our vision for 10 years from now is that drug repurposing will work efficiently, so projects with real potential don\u2019t get stuck in bottlenecks.\u2019<\/p>\n

Another\u00a0Horizon project, the brand new REPO4EU<\/a>\u00a0describes itself as a \u201cplatform for precision drug repurposing\u201d. REPO4EU will be working closely with the REMEDI4ALL group to make the process fast, cost-effective and patient-centric. With ambitions to turbo-boost the world of drug repurposing, they will address unmet medical needs in all disease areas.<\/p>\n

Funded by the Horizon Europe programme to the tune of \u20ac23 million, the project also aims to develop a permanent European infrastructure that can serve as a resource for every potential researcher or small-to-medium-size enterprise interested in drug repurposing. But that\u2019s where the similarities between the two projects end.<\/p>\n

The \u201chigh-precision\u201d REPO4EU approach to finding new applications for registered drugs (based on a seminal study from 2015 on the relationships between diseases) is predicated on the finding that, when all human diseases are plotted on a network map, disease clusters emerge.<\/p>\n

Significantly, diseases in a given cluster share the same risk genes. In other words, specific gene mutations can trigger a cascade of events that can give rise to any disease from within its cluster.<\/p>\n

The REPO4EU team position is that a disease should therefore be described less as an \u201corgan malfunction\u201d (say, heart or kidney failure) and more as a precise \u201cmechanistic\u201d problem (i.e. focused on the mechanisms giving rise to disease). This is nothing short of a paradigm shift.<\/p>\n

Precision cure<\/strong><\/p>\n

In their quest to find new purposes for established medicines, the REPO4EU researchers are zeroing in on drugs that are known to target a particular mechanism, explained Prof. Harald Schmidt, coordinator of REPO4EU and professor of pharmacology at Maastricht University. Next, the team will design high-precision clinical trials to \u2018rapidly and safely cure\u2019 conditions that share this mechanism.<\/p>\n

\u2018Patients will be selected based on symptoms and, more importantly, the detection of the disease mechanism. This means every treated patient is expected to benefit,\u2019 said Prof. Schmidt.<\/p>\n

He believes the project will herald the end of the organ-based structure of medicine. \u2018Right now, we hardly understand the cause of any chronic disease at the level of genes and cellular signalling, and so we\u2019re left with chronically treating symptoms with low precision and limited patient benefit.\u2019<\/p>\n

He added: \u2018The traditional, reductionist \u201cone disease, one target, one drug\u201d dogma has had its time. Ours is a completely new approach to medicine, and our team is totally convinced by it. Network medicine will redefine what we call a disease, how we diagnose it, and how we cure it \u2013 not just treat it.\u2019<\/p>\n

Research in this article was funded by the EU. The article was originally published\u202fin <\/em>Horizon<\/em><\/a>, the EU Research and Innovation Magazine.\u202f\u00a0<\/em><\/p>\n

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