{"id":2645,"date":"2024-01-16T15:40:32","date_gmt":"2024-01-16T15:40:32","guid":{"rendered":"https:\/\/horizon.peachpuff-wolverine-566518.hostingersite.com\/?p=2645"},"modified":"2024-01-16T15:40:32","modified_gmt":"2024-01-16T15:40:32","slug":"on-the-move-medical-imaging-goes-mobile-for-better-healthcare","status":"publish","type":"post","link":"https:\/\/scienceblog.com\/horizon\/2645\/on-the-move-medical-imaging-goes-mobile-for-better-healthcare\/","title":{"rendered":"On the move: medical imaging goes mobile for better healthcare"},"content":{"rendered":"

Researchers are developing portable ultrasound devices that promise improved treatments for millions of patients.<\/p>\n

By<\/em><\/strong> \u00a0Helen Massy-Beresford<\/p>\n

When someone suffers a stroke, the timing of medical help is crucial. The faster treatment is given, the greater the chance the person will fully recover.<\/p>\n

But doctors need to know what kind of stroke to treat.<\/p>\n

60-minute window<\/strong><\/p>\n

For example, thrombolytic drugs, which break up blood clots, would help in the case of a stroke that blocks blood flow to the brain. The same drugs would have catastrophic consequences in the event of a stroke that involves bleeding in the brain.<\/p>\n

\u2018There\u2019s a huge timing problem,\u2019 said Dr Olivier Couture, research director at the Biomedical Imaging Laboratory in the French capital Paris. \u2018If you treat people within the first hour \u2013 the golden hour \u2013 the stroke has a reduced impact on their life.\u2019<\/p>\n

The Biomedical Imaging Laboratory is run jointly by the French National Centre for Scientific Research, or CNRS, Sorbonne University and the French National Institute of Health and Medical Research, also known as Inserm.<\/p>\n

Couture leads a project that received EU funding to help doctors determine the appropriate treatment for a stroke faster. Named ResolveStroke<\/a>, the project is due to end in February 2024 after five and a half years.<\/p>\n

The stakes are high.<\/p>\n

Strokes permanently disable around 5 million people a year globally \u2013 in addition to killing 6 million worldwide annually.<\/p>\n

In Europe, an estimated 1.5 million people<\/a> have a stroke each year, with a third remaining dependent on outside help.<\/p>\n

New view<\/strong><\/p>\n

The ResolveStroke researchers are counting on ultrasound imaging instead of conventional diagnostic techniques \u2013 mainly CT and MRI scans \u2013 to treat strokes.<\/p>\n

While they provide clear pictures, CT and MRI scans require specialised centres and highly trained operators, involve cumbersome machines and, above all, take time.<\/p>\n

Ultrasound uses sound waves to generate images and, because it\u2019s more portable, offers the prospect of faster diagnoses \u2013 even from ambulances. But ultrasound images tend to be less precise because the scattering of waves in tissue limits resolution.<\/p>\n

The project team has built on an idea known as super-resolution ultrasound. This technique maps out the blood vessels by using a contrast agent, namely clinically approved microbubbles, to track the blood flowing through them rather than the vessels themselves as in traditional ultrasound. This gives a clearer picture of blood flow.<\/p>\n

Scanner on wheels<\/strong><\/p>\n

After initially testing the technology by scanning the brains of rats, the researchers progressed to sheep and eventually developed a scanner that received the go-ahead for tests on human patients in November 2023. The team is preparing for trials at the Bichat-Claude Bernard Hospital in Paris.<\/p>\n

\u2018The dream is to reduce the cost and improve the portability and the access of it \u2013 basically put it in ambulances,\u2019 Couture said.<\/p>\n

The researchers have set up a company, also called ResolveStroke, to push forward commercialisation. They hope to have European approval for the scanner by 2025.<\/p>\n

Faster and better stroke treatment has the potential to reduce healthcare expenditure substantially.<\/p>\n

The total cost of stroke care in Europe was \u20ac60 billion in 2017 and, with the continent\u2019s population ageing, could rise to \u20ac86 billion in 2040 without better prevention, treatment and rehabilitation, according to a European advocacy organisation<\/a>.<\/p>\n

Handheld help<\/strong><\/p>\n

As Couture and his team press ahead with their goal of getting ultrasound scanners into ambulances, EU-funded researchers in neighbouring Belgium are seeking to deploy ultrasound imaging more widely for a broader number of health uses.<\/p>\n

This group of experts is developing a handheld ultrasound probe that should facilitate diagnoses by doctors and improve everything from maternity care to the treatment of sports injuries.<\/p>\n

The project is called\u00a0LucidWave<\/a> and runs for three years until mid-2025. The portable machines being developed are around 20 centimetres in length and rectangular in shape.<\/p>\n

The LucidWave team wants to make them available not just in radiology departments but also elsewhere in hospitals such as surgery rooms and even in care homes for the elderly.<\/p>\n

\u2018We want to offer ultrasound medical imaging that is handheld and wireless,\u2019 said Bart van Duffel, a project member who is innovation manager for membrane, surface and thin film technology at university KU Leuven in the Belgian region of Flanders.<\/p>\n

User friendly<\/strong><\/p>\n

To do that, the team has brought a different transducer technology to the probe using micro-electromechanical systems, or MEMS, which are comparable to the chips found in smartphones.<\/p>\n

The alternative technology is based on piezoelectric micromachined ultrasonic transducers, or PMUTs \u2013 tiny silicone film \u201cdrums\u201d that vibrate when exposed to a voltage and produce the ultrasound waves needed for imaging that can cover various parts of the human body.<\/p>\n

The images generated are analysed by LucidWave software, including artificial intelligence, which can swiftly process the data and provide a pre-diagnosis for medical experts.<\/p>\n

\u2018The project prototype is straightforward to use so medical and healthcare professionals of all kinds \u2013 not only ultrasound specialists \u2013 can make use of it,\u2019 said Dr Sina Sadeghpour, research manager at KU Leuven and leader of LucidWave.<\/p>\n

The team is testing the prototype on cadavers with the aim of improving the image quality \u2013 an important step towards applying for permission to undertake trials with living people and eventually bring the device to market.<\/p>\n

The researchers estimate the device could be fully approved and commercially available in around five years.<\/p>\n

\u2018We want to make ultrasound imaging widely available and affordable without compromising on functionality and performance,\u2019 van Duffel said. \u2018We see this new ultrasound technology as a kind of stethoscope of the future.\u2019<\/p>\n

Research in this article was funded by the EU\u2019s Horizon Programme via the European Research Council (ERC) and the European Innovation Council (EIC). The views of the interviewees don\u2019t necessarily reflect those of the European Commission.<\/em><\/p>\n

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