{"id":421,"date":"2018-08-21T11:56:12","date_gmt":"2018-08-21T11:56:12","guid":{"rendered":"http:\/\/horizon.peachpuff-wolverine-566518.hostingersite.com\/?p=421"},"modified":"2018-08-21T11:56:12","modified_gmt":"2018-08-21T11:56:12","slug":"genetic-error-led-humans-to-evolve-bigger-but-more-vulnerable-brains","status":"publish","type":"post","link":"https:\/\/scienceblog.com\/horizon\/421\/genetic-error-led-humans-to-evolve-bigger-but-more-vulnerable-brains\/","title":{"rendered":"Genetic error led humans to evolve bigger, but more vulnerable, brains"},"content":{"rendered":"
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Newly-discovered genes that helped supersize human brains along with DNA retrieved from extinct humans, which can still be found in people living today, are expanding scientists\u2019 understanding of how our species evolved.<\/strong><\/p>\n

One of the major features that distinguish humans from other primates is the size of our brains, which underwent rapid evolution from about two to three million years ago in a group of our ancestors in Africa called the\u00a0Australopithecines.\u00a0<\/em>During this period, the human brain grew almost three-fold to reach its current size. Scientists know this from skull remains, but have puzzled over how it happened.<\/p>\n

This year, the mystery was partially solved by Professor\u00a0Pierre Vanderhaeghen<\/a>at the Flanders Institute for Biotechnology in Belgium. Prof. Vanderhaeghen, who was conducting his work as part of the GENDEVOCORTEX project, went on a hunt for the genes that drove the growth of human brains.<\/p>\n

Scientists had suspected that brain expansion began in our human ancestors when they evolved genes that are switched on in the foetus, when a lot of key brain development occurs. Prof. Vanderhaeghen therefore looked for genes present in human foetal tissue, but missing from our closest living relatives, apes.<\/p>\n

His lab discovered\u00a035 hominid\u200a\u2014\u200apresent only in apes and humans\u200a\u2014\u200agenes<\/a>that were active in foetal brain tissue. They then became intrigued by three specific genes\u200a\u2014\u200aall similar to NOTCH genes, an ancient gene family involved in sending messages between cells and that are present in all animals. They found that the three new genes, collectively named NOTCH 2NL, were created by a copy and paste error of an original NOTCH gene.<\/p>\n

This error created entirely new proteins which likely helped our ancestors\u2019 cerebral cortex to balloon. This is the part of our brain responsible for our language, imagination and problem-solving abilities. Scientists at the University of California, Santa Cruz, have also identified the NOTCH 2NL genes in DNA from Homo sapiens\u2019 extinct cousins\u200a\u2014\u200athe Neanderthals and Denisovans.<\/p>\n

\u2018(The NOTCH 2NL) genes are only present in humans today. They were also present in Neanderthal DNA, but not in chimpanzees,\u2019 Prof. Vanderhaeghen said.<\/p>\n

Evolution<\/strong><\/p>\n

These genes control the growth rate and differentiation of brain stem cells\u200a\u2014\u200athe starter cells that multiply and give rise to all neurons in our brain\u200a\u2014\u200acausing them to seed more nerve cells, which in turn helped to expand brain size. The genes likely led to more neurons and brain tissue in our ancestor\u2019s descendants\u200a\u2014\u200aincluding Neanderthals, Denisovans, and modern humans.<\/p>\n

Prof. Vanderhaeghen\u2019s research could also help to provide new insights into brain disorders. The US researchers linked genetic faults in DNA that were very similar to NOTCH 2NL, to children born with enlarged brains or small brains. Many of the new human-specific genes are located in a small area of our genome that plays an important role in brain size, according to Prof. Vanderhaeghen.<\/p>\n

As DNA in this area closely resembles another part of the genome where it was originally cut and pasted from millions of years ago, errors are more likely, said Prof. Vanderhaeghen. \u2018Patients who have (inherited) deletions in this area tend to be at risk of developing schizophrenia, whereas patients with duplications are more at risk of autistic spectrum disorder,\u2019 he said.<\/p>\n

Prof. Vanderhaeghen is now studying some 20 of the remaining human-only genes to see how they contributed to the evolution of the human brain.<\/p>\n

\u2018Something like 40\u201350% of the Neanderthal genome can still be found in people\u00a0today.\u2019
\n– Prof. Svante P\u00e4\u00e4bo, Max Planck Institute for Evolutionary Anthropology, Leipzig,\u00a0Germany<\/p><\/blockquote>\n

The use of genetics to study human evolution in this way is helping to transform our understanding of how our own species compared to our ancestors. Traditionally, scientists have studied extinct species by looking at the fossilised remains of their bones. This was how they discovered the existence of Neanderthals, the extinct human species that lived across Europe and much of Asia before vanishing around 40,000 years ago.<\/p>\n

In the last decade, however, scientists have begun to look at the DNA inside these bones. Professor Svante P\u00e4\u00e4bo, director of the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany, has led the way in sequencing DNA of these extinct humans from small bone fragments.<\/p>\n

This allows scientists to compare modern human DNA with that of extinct humans, rather than just living relatives like chimps. Already, the work has revealed some surprising findings\u200a\u2014\u200aour own species appears to have interbred with some of these ancient relatives during our history.<\/p>\n

Ancient humans<\/strong><\/p>\n

Scientists have found that the DNA of every person outside Africa is 1\u20132% Neanderthal, meaning that these extinct human relatives had offspring with our own ancestors.<\/p>\n

\"That<\/a>
That many people still retain Neanderthal DNA today could mean that it plays a role in our immune system. Image credit\u200a\u2014\u200aFrank Vinken for Max Planck Society<\/figcaption><\/figure>\n<\/div>\n
\n

\u2018Different people tend to carry different pieces of the Neanderthal genome,\u2019 said Prof. P\u00e4\u00e4bo, who is undertaking a project called 100 Archaic Genomes to decipher the DNA of ancient human individuals.<\/p>\n

\u2018Something like 40\u201350% of the Neanderthal genome can still be found in people today,\u2019 he said.<\/p>\n

According to Prof. P\u00e4\u00e4bo, we retained some of this DNA because it offered an advantage to our ancestors. \u2018Some (of this retained DNA) has to do with the immune system, presumably helping us to fight off infectious diseases.\u2019<\/p>\n

The power of genetics to unravel the history of human evolution took a new twist in 2010 after Prof. P\u00e4\u00e4bo\u2019s lab sequenced DNA from a finger bone fragment found by a Russian archaeological team in a remote Siberian cave.<\/p>\n

The analysis revealed the bone belonged to a previously unknown human relative, now called Denisovans after Denisova Cave where the bone was found. This mysterious ancient human species lived at around the same time as Neanderthals, but further east into Asia.<\/p>\n

Last year, Prof. P\u00e4\u00e4bo\u2019s group published DNA sequences from a tooth found in the cave\u200a\u2014\u200athe fourth ever Denisovan discovered. We now know Denisovan DNA carries more variation than Neanderthal DNA, leading scientists to conclude that they were more widespread than the better-known Neanderthals.<\/p>\n

Denisovans left a more impressive stamp on some of us than Neanderthals, according to Prof P\u00e4\u00e4bo. Their DNA can be found in people across Asia today, while indigenous peoples of Papua New Guinea and Australia may carry up to 5%. Tibetans also carry some Denisovan DNA in their genomes, which has helped them adapt to life at high altitudes where there is little oxygen in the atmosphere.<\/p>\n

Prof. P\u00e4\u00e4bo and his colleagues will soon publish their third high-quality genome\u200a\u2014\u200awhere almost the entire DNA sequence is intact\u200a\u2014\u200aof a Neanderthal from Siberia. A deciphered genome of this quality allows for better DNA comparisons and could tell us more about the evolution of important genes\u200a\u2014\u200asuch as those linked to the development and function of the brain. It will add yet another puzzle piece to help us understand the history of our closest extinct relatives, according to Prof. P\u00e4\u00e4bo.<\/p>\n

\u2018There may even be other forms of extinct humans out there to be discovered by studying the DNA of the (ancient) bones we find,\u2019 he said.<\/p>\n

The research in this article was funded by the EU. If you liked this article, please consider sharing it on social media.<\/em><\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Newly-discovered genes that helped supersize human brains along with DNA retrieved from extinct humans, which can still be found in people living today, are expanding scientists\u2019 understanding of how our species evolved. One of the major features that distinguish humans from other primates is the size of our brains, which underwent rapid evolution from about … Read more<\/a><\/p>\n","protected":false},"author":320,"featured_media":422,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"generate_page_header":"","jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[10],"tags":[172,68,69],"class_list":["post-421","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-brain-behavior","tag-dna","tag-evolution","tag-history"],"yoast_head":"\nGenetic error led humans to evolve bigger, but more vulnerable, brains - Horizon Magazine Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/scienceblog.com\/horizon\/421\/genetic-error-led-humans-to-evolve-bigger-but-more-vulnerable-brains\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Genetic error led humans to evolve bigger, but more vulnerable, brains\" \/>\n<meta property=\"og:description\" content=\"Newly-discovered genes that helped supersize human brains along with DNA retrieved from extinct humans, which can still be found in people living today, are expanding scientists\u2019 understanding of how our species evolved. 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