{"id":429,"date":"2018-08-28T10:03:24","date_gmt":"2018-08-28T10:03:24","guid":{"rendered":"http:\/\/horizon.peachpuff-wolverine-566518.hostingersite.com\/?p=429"},"modified":"2018-08-28T10:03:24","modified_gmt":"2018-08-28T10:03:24","slug":"familys-grief-sparks-a-quest-for-better-bladder-cancer-cures","status":"publish","type":"post","link":"https:\/\/scienceblog.com\/horizon\/429\/familys-grief-sparks-a-quest-for-better-bladder-cancer-cures\/","title":{"rendered":"Family\u2019s grief sparks a quest for better bladder cancer cures"},"content":{"rendered":"
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‘Invasive and uncomfortable’ prodedures for detecting if someone has bladder cancer\u00a0could be replaced by urine tests that not only screen for the presence of the disease but also help doctors choose the right course of treatment for a particular patient.<\/strong><\/h3>\n<\/form>\n<\/div>\n
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\u2018Our lives literally came to a stop when my mother was diagnosed with cancer,\u2019 said Dr Gitte Pedersen. \u2018The first treatment didn\u2019t work, neither did the next one. Eventually we just ran out of time.\u2019<\/p>\n

The heartbreak of losing her mother inspired Dr Pedersen and her brother, Morten, to take action and start a Danish biotech company, Genomic Expression, in 2009. \u2018It\u2019s very much a passion project \u2013 we want to help solve this problem.\u2019<\/p>\n

The deeper they looked at modern cancer care, the more convinced they became that a new approach was needed. Dr Pedersen says\u00a0that only about one in four treatments prolong life, and\u00a0as many drugs don’t work, tens of billions of euro are wasted globally every year. \u2018My brother and I are both scientists and, understanding genetics, we concluded that there had to be a better way,’ she said.<\/p>\n

Their goal has been to apply the latest findings from basic research in areas such as genomics to improve the lives of cancer patients. At the heart of their approach are insights that allow patients to be treated according to the underlying cause of their disease.<\/p>\n

Through Genomic Expression, the Pedersens believe they can improve cancer diagnosis and monitoring, help doctors find the right drugs for patients, and make it easier for drug developers to identify suitable patients for clinical trials of new medicines.<\/p>\n

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\u2018My brother and I are both scientists and, understanding genetics, we concluded that there had to be a better way (to treat cancer).’<\/p>\n

Dr Gitte Pedersen, Genomic Expression<\/p>\n<\/blockquote>\n<\/div>\n

For Genomic Expression, bladder cancer is a key target because it is costly to treat due to expensive and invasive diagnostic procedures. It also has a very high recurrence rate of between 50% and 70%, which means that patients undergo lifelong surveillance. Knowing the underlying genetic drivers in a patient\u2019s tumour presents an opportunity to pick the most effective treatment and reduce recurrence.<\/p>\n

The company uses a patented technology that filters urine, allowing bladder tumour cells to be selected and tested for a series of biomarkers \u2013 tell-tale molecular signs of cancer. Diagnostic and treatment choices can then be tailored to the genetic make-up of the tumour cells. Four studies are underway to test the system in people with breast, ovarian, colon and bladder cancer.<\/p>\n

Barriers<\/strong><\/p>\n

One of the barriers to improving outcomes for bladder cancer patients is obtaining early and accurate diagnosis. \u2018The only symptom is blood in the urine,\u2019 said Dr Pedersen, who leads the OneRNA4Bladder project focused on validating a urine-based diagnostic test. \u2018But only one in 10 (people) who present to their doctor with blood in the urine actually have cancer. However, given the risk of serious illness, all are referred to specialist urologists for cystoscopy.\u2019<\/p>\n

Cystoscopy is a highly invasive procedure wherein the bladder is inspected using a small camera inserted into the urinary tract. Patients who have survived cancer are required to have between four and eight cystoscopies per year.<\/p>\n

\u2018It\u2019s an invasive and uncomfortable procedure and causes urinary tract infections in 10% of patients,\u2019 Dr Pedersen said. \u2018The test we are validating would potentially substitute for some or all of these.\u2019<\/p>\n

The urine test would spare patients cystoscopies, save health professionals time, and reduce costs for health systems.<\/p>\n

If all goes to plan, it could even be offered by general practitioners, reducing waiting times by avoiding referrals to hospital specialists.<\/p>\n

\u2018The patient experience will completely change over the next five years,\u2019 Dr Pedersen said. \u2018For monitoring recurrence, the patients will be able to take the test in the comfort of their home and only get called into the doctor\u2019s office if the test is positive. That will support adherence, which is a problem for older patients who are immobile, as well as patients who simply refuse to undergo cystoscopy several times a year.\u2019<\/p>\n

Another way\u00a0of detecting the presence and nature of\u00a0tumours\u00a0is\u00a0by\u00a0analysing\u00a0the small protein strands known as peptides. By identifying the combination of peptides in a urine sample and analysing this through mathematical models and data analytics, scientists can tell how aggressive a cancer is likely to be.<\/p>\n

Mosaiques Diagnostics, a German\u00a0biotech company,\u00a0is using these predictive qualities of peptide analysis to develop a bladder cancer urine test. The work falls under several projects, which have been working on\u00a0different aspects of the test.<\/p>\n

The company uses an approach known as capillary electrophoresis coupled to mass spectrometry (CE-MS), to profile bladder cancer at the molecular level by analysing a urine sample.<\/p>\n

\u2018The system can detect up to 22,000 peptides which are initially separated depending on their electrical mobility (charge),\u2019 said Dr Maria Frantzi, a postdoctoral researcher at Mosaiques Diagnostics working on a project called TheranOMICS.<\/p>\n

Personalised<\/strong><\/p>\n

Scientists can test a single urine sample for several diseases at once. This information is then checked against a database including more than 50,000 patients to determine the molecular characteristics of the tumour in that particular person.<\/p>\n

\u2018By identifying the combination of peptides present in urine, we can go back to the patient with a score indicating the probability of disease being present,\u2019 Dr Frantzi said. \u2018We could also calculate the risk of the disease recurring in patients who have been successfully treated for cancer.\u2019 This can alert the urologist and guide personalised patient management.<\/p>\n

This approach has the potential to improve bladder cancer detection, but ultimately, shifting to a new system may take time.<\/p>\n

\u2018Cystoscopy cannot see all tumours, particularly those high up in the bladder, but this molecular approach is more precise,\u2019 said Professor Harald Mischak, founder of Mosaiques Diagnostics.<\/p>\n

\u2018I hope clinical practice will change in the coming years, but this will require a willingness from clinics to implement new approaches, as well as regulatory approval and reimbursement. When it comes to changing patient care, science is not the only piece of the puzzle.\u2019<\/p>\n

Originally published on Horizon<\/a>.\u00a0<\/i><\/p>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

‘Invasive and uncomfortable’ prodedures for detecting if someone has bladder cancer\u00a0could be replaced by urine tests that not only screen for the presence of the disease but also help doctors choose the right course of treatment for a particular patient. \u2018Our lives literally came to a stop when my mother was diagnosed with cancer,\u2019 said … Read more<\/a><\/p>\n","protected":false},"author":313,"featured_media":430,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"generate_page_header":"","jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[12],"tags":[94,71,37,95,79,24],"class_list":["post-429","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health","tag-cancer","tag-genetics","tag-health","tag-medicine","tag-research","tag-science"],"yoast_head":"\nFamily\u2019s grief sparks a quest for better bladder cancer cures - Horizon Magazine Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/scienceblog.com\/horizon\/429\/familys-grief-sparks-a-quest-for-better-bladder-cancer-cures\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Family\u2019s grief sparks a quest for better bladder cancer cures\" \/>\n<meta property=\"og:description\" content=\"‘Invasive and uncomfortable’ prodedures for detecting if someone has bladder cancer\u00a0could be replaced by urine tests that not only screen for the presence of the disease but also help doctors choose the right course of treatment for a particular patient. \u2018Our lives literally came to a stop when my mother was diagnosed with cancer,\u2019 said ... 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