{"id":784,"date":"2019-04-23T08:53:31","date_gmt":"2019-04-23T08:53:31","guid":{"rendered":"http:\/\/horizon.peachpuff-wolverine-566518.hostingersite.com\/?p=784"},"modified":"2019-05-06T12:07:54","modified_gmt":"2019-05-06T12:07:54","slug":"danish-dogs-to-receive-virus-inspired-cancer-vaccine-treatment","status":"publish","type":"post","link":"https:\/\/scienceblog.com\/horizon\/784\/danish-dogs-to-receive-virus-inspired-cancer-vaccine-treatment\/","title":{"rendered":"Danish dogs to receive virus-inspired cancer vaccine treatment"},"content":{"rendered":"
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Fifteen Danish dogs with advanced cancer are to receive a new type of therapeutic vaccine which, it is hoped, will rid them of the disease and pave the way for human testing.<\/strong><\/p>\n<\/div>\n<\/div>\n<\/div>\n

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Unlike preventative vaccines, therapeutic vaccines are not used to prevent someone from getting a disease but rather to support an immune system that is already fighting an invader. This one should trick the dogs\u2019 immune systems into thinking they are under attack by a virus and stimulate a response.<\/p>\n

The work\u00a0is part of international effort to harness the vigorous response that immune systems mount against viruses and redirect it to deal with other types of attack \u2013 by bacteria, parasites and some types of cancer.<\/p>\n

The research is led by Professor Ali Salanti, translational microbiologist at the University of Copenhagen, Denmark and stems from work in a variety of projects including\u00a0PLACMALVAC<\/a>.<\/p>\n

\u2018We will test the vaccine in pets coming in to the veterinarians with this disseminated cancer and … with (the results) we will try to raise money for production and (trials) in humans,\u2019 he said.<\/p>\n

His team, and others around the world, were intrigued with the success of a new vaccine against cervical cancer and teamed up with Dr John Schiller from the US National Cancer Institute, who helped develop the vaccine, to explore why it worked.<\/p>\n

Shell<\/strong><\/p>\n

Cervical cancer is caused by a virus and the vaccine consists of the shell of the virus \u2013 known as a capsid \u2013 emptied of its genetic material to make it harmless. The capsid is enough to trigger the immune system to build lifelong defences against the infection and therefore to cervical cancer.<\/p>\n

Most cancers are not caused by viruses, but both carry markers on their surfaces, known as antigens, which trigger the immune system to make antibodies with which to fight them. However, the problem is that tumours also deploy a range of tactics to evade the immune system and often the body\u2019s response is too weak to attack them effectively.<\/p>\n

Prof. Salanti\u2019s group has patented a way of making capsid-like particles from proteins, which can be used to carry molecules such as antigens into the body. To test whether this approach could help against cancer, Prof. Salanti and his team recreated markers found on breast cancer tumours in mice and joined them to the capsid-like particles. They then injected this compound into mice that had been genetically modified to have breast cancer. The mouse immune systems responded as if they were under viral attack, the tumours shrank and, in some cases, disappeared.<\/p>\n

He hopes that this method of stimulating the immune system could have implications beyond treating cancer.<\/p>\n

\u2018The idea is that if we could make any protein look like (a capsid-like particle) then we could life-long protect against any disease (where antibodies are important),\u2019 said Prof. Salanti.<\/p>\n

The next stage is to test it in dogs because their cancers carry the same identifying proteins on their surfaces as humans do, with the aim of moving towards human trials.<\/p>\n

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\u2018We will start with a cancer vaccine and then \u2026 develop the malaria vaccine.\u2019<\/p>\n

Professor Ali Salanti, University of Copenhagen, Denmark<\/p>\n<\/blockquote>\n<\/div>\n

Malaria<\/strong><\/p>\n

But for Prof. Salanti, proving the vaccine works in humans<\/p>\n

is a step towards another, seemingly unconnected goal: developing a vaccine against pregnancy-associated malaria.<\/p>\n

When Prof. Salanti was a postgraduate researcher he discovered the reason why women, who have often developed a resistance to malaria when they were younger, become vulnerable in pregnancy \u2013 often losing their babies. Malaria during pregnancy is responsible for\u00a015% of maternal deaths<\/a>\u00a0and\u00a0if it doesn’t\u00a0kill the foetus\u00a0it can reduce its birth weight.<\/p>\n

During his PhD, Prof. Salanti found that the answer lay in the placenta \u2013 the temporary organ that forms between a mother and her growing foetus. Dotted along the mother\u2019s side are little hooks, or receptors. \u00a0And scattered on the surface of malaria-infected red blood cells are proteins that are perfectly designed to grip tightly to these hooks, disrupting placental business.<\/p>\n

Prof. Salanti reckoned that if he could vaccinate a woman with that protein found on the surface of the malaria-infected cells it might trigger her immune system to produce antibodies that would be ready to attack the parasite \u2013 and thus protect her placenta \u2013 when she became pregnant.<\/p>\n

Some 15 years later, Prof. Salanti has developed just such a vaccine. It has\u00a0proved safe in first-stage human trials<\/a>\u00a0in Germany and has just passed a second set of safety trials \u2013 as yet unpublished \u2013 in Benin, showing that it is safe in women of child-bearing age. However, Prof. Salanti believes that the vaccine in its current form is not optimal.<\/p>\n

There has been growing evidence over the last decade that many vaccines against bacterial and parasitic infections confer only short-lived protection, meaning that repeat vaccinations are needed. This, he believes, is not a practical solution for cash-strapped African countries.<\/p>\n

Instead, Prof. Salanti has been searching for a different way of delivering vaccines and he hopes that the capsid-based virus-like particle technology used in the dog trials may provide the answer.<\/p>\n

\u2018We will start with a cancer vaccine and then \u2026 develop the malaria vaccine,\u2019 he said.<\/p>\n

Professor Robert Sauerwein, of Radboud\u00a0University Nijmegen in the Netherlands, member of the WHO\u2019s Malaria Vaccine Advisory Committee, said using such an approach for malaria is a possibility that\u2019s worth exploring. \u2018Virus-like particles may induce better responses, but that is very much product dependent,\u2019 he said. \u2018It\u2019s worth a try case-by-case but there is no guarantee.\u2019<\/p>\n

In the meantime, Danish dogs may be a long way from Benin, but Prof Salanti is trying to direct his cancer research, too, towards low-cost solutions.<\/p>\n

\u2018People forget that \u2026 in Africa it\u2019s a death sentence to get most types of cancer. So our hope is we can make something more cost-effective that will also be available for these parts of the world.\u2019<\/p>\n

The research in this article was funded by the EU. If you liked this article, please consider sharing it on social media.<\/em><\/p>\n<\/div>\n<\/div>\n<\/div>\n

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Originally published on\u00a0Horizon<\/a><\/em><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

More info<\/strong><\/p>\n

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PLACMALVAC<\/a><\/p>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Fifteen Danish dogs with advanced cancer are to receive a new type of therapeutic vaccine which, it is hoped, will rid them of the disease and pave the way for human testing. Unlike preventative vaccines, therapeutic vaccines are not used to prevent someone from getting a disease but rather to support an immune system that … Read more<\/a><\/p>\n","protected":false},"author":316,"featured_media":785,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"generate_page_header":"","jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[12],"tags":[94,253,37,251,252],"class_list":["post-784","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health","tag-cancer","tag-dogs","tag-health","tag-malaria","tag-vaccine"],"yoast_head":"\nDanish dogs to receive virus-inspired cancer vaccine treatment - Horizon Magazine Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/scienceblog.com\/horizon\/784\/danish-dogs-to-receive-virus-inspired-cancer-vaccine-treatment\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Danish dogs to receive virus-inspired cancer vaccine treatment\" \/>\n<meta property=\"og:description\" content=\"Fifteen Danish dogs with advanced cancer are to receive a new type of therapeutic vaccine which, it is hoped, will rid them of the disease and pave the way for human testing. 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The main question, they say, is which vaccine to prioritise first.\u2026","rel":"","context":"In "Health"","block_context":{"text":"Health","link":"https:\/\/scienceblog.com\/horizon\/category\/health\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2021\/04\/Montage1.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2021\/04\/Montage1.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2021\/04\/Montage1.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2021\/04\/Montage1.jpg?resize=700%2C400&ssl=1 2x"},"classes":[]},{"id":1217,"url":"https:\/\/scienceblog.com\/horizon\/1217\/five-things-you-need-to-know-about-mrna-vaccines\/","url_meta":{"origin":784,"position":1},"title":"Five things you need to know about: mRNA vaccines","author":"Joanna Roberts","date":"April 1, 2020","format":false,"excerpt":"The race for a vaccine against the novel coronavirus, or SARS-CoV-2, is on, with\u00a054 different vaccines under development, two of which are already being tested in humans, according to the World Health Organization. And among the different candidates is a new player on the scene \u2013 mRNA vaccines. One mRNA\u2026","rel":"","context":"In "Health"","block_context":{"text":"Health","link":"https:\/\/scienceblog.com\/horizon\/category\/health\/"},"img":{"alt_text":"According to Prof. Bekeredjian-Ding, an approved mRNA coronavirus vaccine would be easier and faster to produce and thus deploy worldwide than a conventional vaccine. Image credit - Unsplash\/Liliya Lisa","src":"https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2020\/04\/liliya-lisa-sm.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2020\/04\/liliya-lisa-sm.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2020\/04\/liliya-lisa-sm.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2020\/04\/liliya-lisa-sm.jpg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2020\/04\/liliya-lisa-sm.jpg?resize=1050%2C600&ssl=1 3x"},"classes":[]},{"id":1500,"url":"https:\/\/scienceblog.com\/horizon\/1500\/qa-how-vaccines-can-strengthen-immune-response-beyond-a-specific-disease\/","url_meta":{"origin":784,"position":2},"title":"Q&A: How vaccines can strengthen immune response beyond a specific disease","author":"Horizon Magazine","date":"November 25, 2020","format":false,"excerpt":"Live vaccines can give health effects beyond just protecting us from a specific disease and may even help us combat other infections such as Covid-19, according to Christine Stabell Benn, a professor in global health at the University of Southern Denmark. We often think about vaccines protecting us against a\u2026","rel":"","context":"In "Health"","block_context":{"text":"Health","link":"https:\/\/scienceblog.com\/horizon\/category\/health\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2020\/11\/kid-vaccine-sm.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2020\/11\/kid-vaccine-sm.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2020\/11\/kid-vaccine-sm.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2020\/11\/kid-vaccine-sm.jpg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2020\/11\/kid-vaccine-sm.jpg?resize=1050%2C600&ssl=1 3x"},"classes":[]},{"id":1449,"url":"https:\/\/scienceblog.com\/horizon\/1449\/qa-cancer-vaccines-will-not-replace-surgery-or-chemo-but-could-give-long-lasting-immunity\/","url_meta":{"origin":784,"position":3},"title":"Q&A: \u2018Cancer vaccines will not replace surgery or chemo but could give long-lasting immunity\u2019","author":"Horizon Magazine","date":"September 24, 2020","format":false,"excerpt":"by\u00a0Ian Le Guillou A cancer vaccine needs to tackle the dual issues of cancers being able to hide from the immune system and suppress our immune defences. Recent advances are bringing cancer vaccines much closer to reality, giving patients another weapon in their arsenal of cancer treatments, according to Dr\u2026","rel":"","context":"In "Health"","block_context":{"text":"Health","link":"https:\/\/scienceblog.com\/horizon\/category\/health\/"},"img":{"alt_text":"A cancer vaccine needs to tackle the dual issues of cancers being able to hide from the immune system and suppress our immune defences. Image credit - Municipalidad de C\u00f3rdoba\/Flickr, licenced under CC BY-NC-ND 2.0","src":"https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2020\/09\/Women-vaccine.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2020\/09\/Women-vaccine.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2020\/09\/Women-vaccine.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2020\/09\/Women-vaccine.jpg?resize=700%2C400&ssl=1 2x"},"classes":[]},{"id":739,"url":"https:\/\/scienceblog.com\/horizon\/739\/a-new-tb-vaccine-is-within-reach-prof-helen-mcshane\/","url_meta":{"origin":784,"position":4},"title":"A new TB vaccine is within reach \u2013 Prof. Helen McShane","author":"Gary Finnegan","date":"March 22, 2019","format":false,"excerpt":"Nearly 100 years ago scientists developed a vaccine for tuberculosis (TB). Today, there are 10 million new cases worldwide and\u00a01.6 million deaths\u00a0from the disease every year. Increasingly, these cases are becoming difficult to treat as the bug that causes the disease can be resistant to antibiotics. However, several new TB\u2026","rel":"","context":"In "Health"","block_context":{"text":"Health","link":"https:\/\/scienceblog.com\/horizon\/category\/health\/"},"img":{"alt_text":"Image credit - Public Domain Files, this picture is in the public domain","src":"https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2019\/03\/tblung.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2019\/03\/tblung.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2019\/03\/tblung.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2019\/03\/tblung.jpg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2019\/03\/tblung.jpg?resize=1050%2C600&ssl=1 3x, https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2019\/03\/tblung.jpg?resize=1400%2C800&ssl=1 4x"},"classes":[]},{"id":1523,"url":"https:\/\/scienceblog.com\/horizon\/1523\/five-things-you-need-to-know-about-mrna-vaccine-safety\/","url_meta":{"origin":784,"position":5},"title":"Five things you need to know about: mRNA vaccine safety","author":"Horizon Magazine","date":"December 11, 2020","format":false,"excerpt":"The world\u2019s first mRNA vaccine has\u00a0begun its rollout\u00a0after being produced at unprecedented speed as part of the global effort to end the Covid-19 pandemic. A second one is hot on its heels. The two \u2013 one made by Pfizer\/BioNTech and the other by Moderna \u2013 mark the first time this\u2026","rel":"","context":"In "Health"","block_context":{"text":"Health","link":"https:\/\/scienceblog.com\/horizon\/category\/health\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2020\/12\/ChildVaccine.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2020\/12\/ChildVaccine.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2020\/12\/ChildVaccine.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2020\/12\/ChildVaccine.jpg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/scienceblog.com\/horizon\/wp-content\/uploads\/sites\/4\/2020\/12\/ChildVaccine.jpg?resize=1050%2C600&ssl=1 3x"},"classes":[]}],"_links":{"self":[{"href":"https:\/\/scienceblog.com\/horizon\/wp-json\/wp\/v2\/posts\/784","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/scienceblog.com\/horizon\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/scienceblog.com\/horizon\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/scienceblog.com\/horizon\/wp-json\/wp\/v2\/users\/316"}],"replies":[{"embeddable":true,"href":"https:\/\/scienceblog.com\/horizon\/wp-json\/wp\/v2\/comments?post=784"}],"version-history":[{"count":0,"href":"https:\/\/scienceblog.com\/horizon\/wp-json\/wp\/v2\/posts\/784\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/scienceblog.com\/horizon\/wp-json\/wp\/v2\/media\/785"}],"wp:attachment":[{"href":"https:\/\/scienceblog.com\/horizon\/wp-json\/wp\/v2\/media?parent=784"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/scienceblog.com\/horizon\/wp-json\/wp\/v2\/categories?post=784"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/scienceblog.com\/horizon\/wp-json\/wp\/v2\/tags?post=784"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}