1.0Josh Mitteldorfhttps://scienceblog.com/joshmitteldorfJosh Mitteldorfhttps://scienceblog.com/joshmitteldorf/author/joshmitteldorf/Can we trust methylation clocks?rich600338<blockquote class="wp-embedded-content" data-secret="p0lyNel5mk"><a href="https://scienceblog.com/joshmitteldorf/2022/03/04/can-we-trust-methylation-clocks/">Can we trust methylation clocks?</a></blockquote><iframe sandbox="allow-scripts" security="restricted" src="https://scienceblog.com/joshmitteldorf/2022/03/04/can-we-trust-methylation-clocks/embed/#?secret=p0lyNel5mk" width="600" height="338" title="“Can we trust methylation clocks?” — Josh Mitteldorf" data-secret="p0lyNel5mk" frameborder="0" marginwidth="0" marginheight="0" scrolling="no" class="wp-embedded-content"></iframe><script>
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https://scienceblog.com/joshmitteldorf/wp-content/uploads/sites/2/2022/03/Clocks.png1386639A methylation clock is an empirical construct. There is no understanding of physiology or metabolism built into the process. The clock is engineered to do the best job predicting (in the case of the GRIM-Age clock, for example) future mortality and morbidity based on methylation patterns. The whole process is agnostic about biological mechanism. It ... Read more