{"id":205,"date":"2014-02-04T01:49:35","date_gmt":"2014-02-04T01:49:35","guid":{"rendered":"http:\/\/joshmitteldorf.peachpuff-wolverine-566518.hostingersite.com\/?page_id=205"},"modified":"2018-04-11T05:30:08","modified_gmt":"2018-04-11T05:30:08","slug":"index-to-this-blog","status":"publish","type":"page","link":"https:\/\/scienceblog.com\/joshmitteldorf\/index-to-this-blog\/","title":{"rendered":"Index to This Blog"},"content":{"rendered":"

Comprehensive Index of Posts to Josh Mitteldorf\u2019s Aging Blog \u00a0(2012 –\u00a0<\/strong><\/p>\n

Sept-Dec 2012
\n<\/strong>Can telomere herapies help us live longer?
\n<\/a>Vitamin D and Aspirin
\n<\/a>Is Metformin an Anti-Aging Drug?
\n<\/a>Anti-oxidants: A Disappointment or Worse
\n<\/a>Mortality and Life Expectancy
\n<\/a>Telomerase as a Fountain of Youth
\n<\/a>What would it mean to live forever?
\n<\/a>Rising Life Expectancy, but not in the US
\n<\/a>Can having children help you live longer?
\n<\/a>Ideal Weight an Illusion<\/a><\/p>\n

Jan-Mar 2013
\n<\/strong>Is Aging Active Self-Destruction?
\n<\/a>How can we Stop Killing Ourselves (4 modes of programmed self-destruction)
\n<\/a>SkQ: Putting the Brakes on Cell Suicide
\n<\/a>Spectacular success with Buckyballs
\n<\/a>Declining Force of Natural Selection
\n<\/a>The China Study (veganism)
\n<\/a>DNA Methylation \u2013 an aging clock
\n<\/a>Cold temperature, life span, rate-of-living hypothesis
\n<\/a>Thymic Involution
\n<\/a>Resveratrol & Sirtuins
\n<\/a>Deprenyl
\n<\/a>Young Blood, Katcher, Heterochronic Plasma Exchange<\/a><\/p>\n

Apr-Jun 2013
\n<\/strong>Immune System and Cancer
\n<\/a>Mutilevel Selection and Evolution of Aging I
\n<\/a>Mutilevel Selection and Evolution of Aging II
\n<\/a>Intermittent Fasting
\n<\/a>Nervous System controls rate of aging
\n<\/a>Methionine Restriction
\n<\/a>\u201cNatural anti-aging\u201d an oxymoron
\n<\/a>Short takes from AGE mtg 2013
\n<\/a>How to be skinny (weight loss tips)
\n<\/a>Dietary Salt: Science corrects a long-standing error
\n<\/a>Rhodiola<\/a><\/p>\n

July-Sept 2013
\n<\/strong>Demographic Theory of Aging
\n<\/a>Cell Phones and Cancer
\n<\/a>Evolution of Evolution<\/a>\u00a0(Evolvability 1)
\nEvolution of Evolution (Evolvability 2)
\n<\/a>Osteoporosis
\n<\/a>How does aspirin work?<\/a>
\n(Does it extend life by thinning the blood or by reducing inflammation? \u00a0Only the latter can be considered truly anti-aging)
\nMeditation and Longevity
\n<\/a>Natural selection has rewarded those who contribute to the community with long life
\n<\/a>New Take on Free Radicals
\n<\/a>Conference Report: \u00a0SENS-6
\n<\/a>Creative deprivation: how to get less from your food
\n<\/a>Aging and LIfe Extension: Unexpected Lessons from Evolution<\/a><\/p>\n

Oct-Dec 2013
\n<\/strong>Combining biochemical pathways: recipe for the Youth Pill
\n<\/a>How is sex like Obamacare?<\/a>\u00a0(The conundrum of the evolution of sex)
\nWithin the paradigm of the \u201cSelfish Gene\u201d, there is no way that gene sharing could have evolved as an adaptation. \u00a0But sex DID evolve. \u00a0This alone should make us wary of the selfish gene.)
\nHow does the body\u2019s hormonal signaling change with age?
\n<\/a>Signal molecules in the blood: what do we have too much as we age?
\n<\/a>Signal molecules in the blood: what do we lose with age?
\n<\/a>Exercise because it feels good! \u00a0(Longer life is a fringe benefit)
\n<\/a>The Selfish Gene vs Multilevel Selection: Aging doesn\u2019t Fit
\n<\/a>The Selfish Gene can\u2019t Explain Aging \u2013 but neither can Multi-level selection
\n<\/a>Political and \u201cmoral\u201d opposition to the anti-aging program
\n<\/a>Anti-aging anti-depressants
\n<\/a>Love of life? or Fear of death? \u00a0Why do we wish to live longer?<\/a><\/p>\n

Jan-Mar 2014
\n<\/strong>Comprehensive Review of Anti-aging Supplements<\/a>\u00a0\u00a0(points to\u00a0AgingAdvice.org<\/a>)
\nMitoQ and SkQ \u2013 designer anti-oxidants that are targeted to the mitochondria
\n<\/a>Telomerase activation: The most promising medical technology on the horizon
\n<\/a>A new way to eliminate senescent cells and a simpler way to make stem cells
\n<\/a>A heavy hitter weighs in against evolutionary theory
\n<\/a>Anti-oxidants can nullify the benefits of exercise
\n<\/a>A well-known Anti-aging Supplement
\n<\/a>One-minute Workouts
\n<\/a>Mitigating risk of Alzheimer\u2019s Disease: More important than we thought
\n<\/a>A one-man experiment in radical anti-aging
\n<\/a>“Life extension supplements” – a reality check<\/a><\/p>\n

Apr-Jun 2014<\/strong>
\nSalt is good for you<\/a>
\nBuild exercise into your day<\/a>
\nThe body doesn’t just wear out as we get older\u00a0(entropy, damage theories of aging) <\/a>
\nLamarckian Inheritance: Passing what you have learned to your children<\/a>
\nWhole Turmeric better than Curcumin?<\/a>
\nGDF11 – A Hormonal Candidate for Rejuvenation (parabiosis, Wager, Conboy, Rubin)<\/a>
\nCholesterol Controversy – Part I<\/a>
\nCholesterol, Part II<\/a>
\nThree-day fast: Day four (Valter Longo)<\/a>
\nHuman mortality, Individual and Collective (environmental politics, ecosystem collapse, existential threats)
\n<\/a>Anisimov – Russian Optimist on Longevity (short peptides, epithalamin, epitalon)<\/a><\/p>\n

July-Sept 2014
\n<\/strong>Vegetarian diet contributes to longevity
\n<\/a>Origin of Life, Part I
\n<\/a>Origin of Life, Part II
\n<\/a>How Aging contributes to Evolvability<\/a>
\nOxytocin, the “love hormone”, is also a longevity hormone<\/a>
\nQuestioning the FDA decision to back away from recommending aspirin<\/a>
\nNotes from Rejuvenation Biotech Conference in Santa Clara<\/a>
\nImminent test of transfusions with young blood as a treatment for Alzheimer’s<\/a>
\nSleep and Longevity<\/a>
\nCRISPR for gene therapy and maybe epigenetic reprogramming<\/a>
\nSubstituting an inefficient means of DNA repair is one way the body slowly kills itself with age<\/a>
\nAging in protozoa is a means of enforcing the imperative for sexual sharing of genes<\/a><\/p>\n

October-December 2014<\/strong>
\nAnti-Aging Oxymorons and Anti-oxymorons<\/a>\u00a0 Why “natural anti-aging” can never work
\nLithium for Life Extension?<\/a>
\nResponse to Gretchen Reynolds, Poking Fun at Longevity Science<\/a>
\nOpen Letter to Google CaLiCo on Priorities in Research<\/a>
\nConference notes: Center for Aging Research, Sherbrooke, QC<\/a>
\nNicotinamide Riboside–Where’s the Beef?<\/a>
\nThree Technologies to Watch<\/a>\u00a0(1)Thymus regrowth w\/ FOXN1; \u00a0(2) New anti-inflammatory drugs based on ARF6 inhibitors; \u00a0(3) Telomere length directly affects gene expression
\nRegeneration in mammals — Ancient capacity is not lost but actively suppressed<\/a>
\nWhat doesn’t kill me makes me stronger<\/a>
\nCaloric Restriction, Hormesis and what they teach us about Evolution<\/a>
\nGinseng for Longevity?<\/a>
\nWhere do we Live?<\/a>\u00a0In our quest for a longer life, I\u00a0often assume “I am my brain”. \u00a0There are reasons from neuroscience and quantum physics to question this perspective.<\/p>\n

Jan-Mar 2015<\/strong>
\nWhat is aging? Most scientists still get it wrong<\/a> (The body doesn’t just wear out. Death is programmed into our genes.)
\nProgrammed death, H. pylori and the legacy of George Williams<\/a> (evolution and gut bacteria)
\nMYC: bad and good, but more bad than good<\/a>
\nDo we really need epidemiology to tell us to get off our duffs?<\/a> (Common sense experience about exercise and sedentary time)
\nAnti-Aging Pills in the News<\/a> (Novartis and Elysium Health)
\nIdeology is Holding Back Aging Research<\/a>
\n“What Looks like Cooperation is Really Selfishness”<\/a> (Critique of the Selfish Gene)
\nKill Senescent Cells Before They Kill You<\/a>
\nTomorrow’s Anti-Aging Therapies, Available Today<\/a> (Bioviva)
\nFertility is Kaput, but Life Goes On<\/a> (Post-Reproductive Life Span)<\/p>\n

Apr-Jun 2015<\/strong><\/p>\n

Magnesium<\/a>
\nTelomerase Does Not Cause Cancer<\/a>
\nNew Study Correlates Telomere Length with Human Mortality<\/a>
\nPterostilbene<\/a>
\nCaution follows last year’s excitement about GDF11<\/a>
\nReview of The Vital Question by Nick Lane, Part 1<\/a>, \u00a0Part 2<\/a>, \u00a0Part 3<\/a>
\nPreserving Insulin Sensitivity–the Anti-Diabetes Diet<\/a>
\nIs there an aging clock in the hypothalamus?<\/a>\u00a0(Orexin, Neuropeptide Y)
\nToward a Pill to Enable Regeneration\u00a0<\/a>
\nCorrelation and causation; \u00a0Nuts and Chocolate<\/a>
\nLongo on how you can eat while fasting; \u00a0Barzilai’s campaign to have aging recognized as a disease<\/a><\/p>\n

Jul-Sep 2015
\n<\/strong>
\nFunding Policies Distort Science<\/a>
\nAging in Microbes<\/a>
\n(despite theory that forbids it, there is aging in protozoans and even bacteria)
\nUpdate and disclaimer<\/a> — the Longo Fasting-mimicking Diet, including\u00a0Recipes<\/a>
\nParkinson’s Disease<\/a>\u00a0— Can anything be done?
\nOverstated claims and oversimple theories<\/a>, including the
\n“Simple genetic switch” in C elegans<\/em>, \u00a0Autophagy, Glycine & mitochondria,
\nGDF11 and TGF-\u03b2)
\nOrcas and Elephants\u2013Aging and the Taboo Subject of Population Regulation
\n<\/a>\u00a0 \u00a0 \u00a0Review of Carl Safina’s book, Beyond Words<\/span>.
\nReport from Rejuvenation Biotech 2015<\/a>
\n(Thymus regeneration, Bruce Ames & Rhonda Patrick, plasma transfusion update
\nWuyi Kong and NPRCPs)
\nHGH and IGF\u2013Promise and Danger
\n<\/a>Untested Treatments for Longevity, and How to Test Them
\n<\/a>\u00a0 \u00a0 \u00a0 (Redundancy and synergy in combining anti-aging treatments)
\nPromise of Novel Alzheimer\u2019s Treatments<\/a>
\nGrowth and Aging; Myostatin and\u00a0Health<\/a><\/p>\n

Oct-Dec 2015
\n<\/strong>Can botanicals replace metformin?<\/a>\u00a0Jiaogulan, Berberine and Gymnema\u00a0
\nFrom Roscoff, with Rotifers<\/a>\u00a0– What I learned at the Monod Conference on comparative biology of aging
\nDoes donating blood extend your life expectancy?<\/a>
\nAnti-Aging Medicine: Two Paths Diverge<\/a>\u00a0– Can aging be reversed with biochemical signals?
\nWe Know Nothing about Longevity Drug Interactions<\/a>\u00a0– a\u00a0proposal for efficiently finding the best dynergies among\u00a0many potential treatments\u00a0
\n<\/strong>Global Consequences of Increased Human Longevity\u00a0<\/a>–\u00a0Life extensionists have an vital interest and responsibility to preserve the planet.<\/p>\n

Jan-Jun\u00a02016
\n<\/strong>Is Aging Controlled from the Brain?<\/a> NPY and ALK5
\n‘One of the most important aging discoveries ever’<\/a>\u00a0“Senolytics” are agents that kill cells that have become senescent (and toxic).
\nWhen your doctor suggests statins (Part 1: Mechanism of Action)<\/a>
\nCholesterol and inflammation; Statins and alternatives (Part II)
\n<\/a>Politics drives a promising nutraceutical underground<\/a>\u00a0 Anatabine
\nRetrotransposons: The Lamarckian Link<\/a>\u00a0 A mechanism by which the body re-engineers its own genome.
\nAging is a Military Coup<\/a>\u00a0Systems that evolved to defend the body against invaders turn self-destructive and destroy the body late in life.
\nEpigenetics of Aging and Prospects for Rejuvenation
\n<\/a>“No Animal Dies of Old Age in the Wild”<\/a>\u00a0The declining force of natural selection is the foundation\u00a0of all evolutionary theories of aging. \u00a0But it doesn’t decline enough to explain anything.
\nCell Phones can Cause Cancer<\/a>\u00a0–\u00a0It’s worthwhile to take precautions with microwaves.
\nA germ theroy of aging?<\/a>\u00a0A new paper proposes that plaques in Alzheimer’s Disease come from inflammatory response to brain infections.
\nLamarck Update<\/a>\u00a0– Evolutionary scientists have assumed for a century\u00a0that traits acquired in a lifetime can’t be passed to offspring. \u00a0Now it’s clear they were wrong. \u00a0How wrong?
\nRapamycin Redux<\/a>\u00a0– Rapamycin is the most effective life extension drug yet tested in rodents. \u00a0Is it safe for humans?\u00a0
\n<\/strong>CRISPR update\u00a0<\/a>– We’re making progress gaining control over gene expression faster than we are learning what to do with our new power.<\/p>\n

Jul-Dec 2016<\/strong><\/p>\n

Video: “Natural Anti-aging” is an oxymoron<\/a>
\nSocial Correlates of Longevity 1: Social status and depression, activism vs powerlessness<\/a>
\nSocial Correlates of Longevity 2: Family<\/a>
\nArthritis: Its importance, its ubiquity, and suggested treatment approaches<\/a>
\nNutritional Geometry 1: Most of us eat too much protein<\/a>
\nNutritional Geometry 2:\u00a0Carb Restriction<\/a>
\nNutritional Geometry 3: Ketosis\u2014 benefits & risks of oil-rich diets<\/a>
\nPost-Reproductive Life Span in C. elegans\u2014How did worms evolve a life span that continues long beyond the end of their fertility?<\/a>
\nPutting the “system” back in Systems Biology<\/a> (Report from Cold Spring Harbor Asia Conference, October, 2016)
\nIn an age of epigenetics, does antagonistic pleiotropy still make sense?<\/a>
\nTraditional Chinese Medicines for Longevity<\/a>
\nDo we have to worry about telomeres being “too long”?<\/a>
\nYamanaka Factors (which turn normal cells into stem cells) used to rejuvenate mice<\/a>
\nEpigenetics and the Direction of Anti-Aging Science<\/a><\/p>\n

Jan-Jun\u00a02017<\/strong><\/p>\n

First fruits of blood plasma research<\/a>\u00a0<\/a>VCAM-1 identified as a blood factor that we have too much of as we age
\nGlycine and mitochondria<\/a>\u00a0<\/a>The simplest amino acid, taken in large enough quantities, encourages new mitochondrial growth
\nFasting-mimicking diet: can you make it a habit?<\/a>
\nNFkB beyond Inflammation<\/a>\u00a0<\/a>Many supplements and drugs inhibit NFkB, with multiple benefits
\nNew database of lifespan trials<\/a>\u00a0 Some surprises include creatine, N-Acetyl cysteine, ginkgo, BHT, and a Chinese herb no one has heard of.
\nSenolytics against aging: snapshot of a fast-moving field<\/a>\u00a0 The latest and greatest senolytic agent promises to kill more senescent cells while leaving other cells unharmed.
\nIs fasting senolytic?<\/a>\u00a0One of the many benefits of intermittent fasting may be in killing off a tiny number of senescent cells that are poising us from the inside.
\nProlonging life with fecal transplants<\/a>\u00a0opening a new area of research: life span of fish is extended just by changing their gut microbiome
\nThe only experimental subject who matters<\/a>\u00a0using self-experimentation to create a personalized program
\nAging gets personal<\/a>\u00a0my mother’s stroke; notes from Geneva symposium; blood plasma transfusions; ideas from Andy Mendelssohn
\nPreventing Dementia\u00a0\u00a0<\/a>physical exercise; individualized programs
\n
\n<\/a><\/p>\n

Jul-Dec 2017<\/strong><\/p>\n

Mitochondria in Aging: I Mechanisms<\/a>
\nMitochondria in Aging: II Remedies<\/a>
\nBuilding the Case that Aging is Controlled from the Brain<\/a>
\nNew Evidence that Long Telomeres cause Cancer, and Why I Think It\u2019s Wrong<\/a>
\nFollow-up on Telomeres: Genetic Studies vs Straight Epidemiology<\/a>
\nIs Cancer a Mitochondrial Disease<\/a> Warburg has a new lease on life
\nAir Pollution and Life Expectancy<\/a>
\nDigging Deeper in Response to Reader Comments<\/a><\/p>\n

    \n
  1. Aspirin, ibuprofen, neproxen<\/li>\n
  2. Does too much exercise cause areterial calcification?<\/li>\n
  3. IP6<\/li>\n
  4. Cancer as Atavism<\/li>\n
  5. News from the World of telomerase activation<\/li>\n
  6. Inheriting Telomere Length<\/li>\n
  7. Tocotrienols<\/li>\n
  8. Low Dose Naltrexone<\/li>\n
  9. Extraordinary story of radiation hormesis<\/li>\n<\/ol>\n

    Aging in the News This Week<\/a><\/p>\n

      \n
    1. High-profile, misleading \u201cproof\u201d that aging is inevitable<\/li>\n
    2. Disappointing results from Alkahest trials<\/li>\n
    3. NewYorker article on exercise in a pill<\/li>\n
    4. Splicing factors rescue senescent cells<\/li>\n<\/ol>\n

      A Dead Theory Still Walks\u00a0<\/a>many biologists continue to relate their findings to the Antagonistic Pleiotropy theory, though it has been falsified many times over.
      \n      Apologia pro Scientia Sua<\/a> (an original poem)
      \n      The Varieties of Aging in Nature\u00a0<\/a>Life spans and also shapes of aging curves vary tremendously. Nature can do what she pleases.
      \n      The Other Half of Science<\/a>\u00a0<\/a>Science has become synonymous with “reductionism”, and unexpected findings are being suppressed because they cannot be explained in those terms.<\/p>\n","protected":false},"excerpt":{"rendered":"

      Comprehensive Index of Posts to Josh Mitteldorf\u2019s Aging Blog \u00a0(2012 –\u00a0 Sept-Dec 2012 Can telomere herapies help us live longer? Vitamin D and Aspirin Is Metformin an Anti-Aging Drug? Anti-oxidants: A Disappointment or Worse Mortality and Life Expectancy Telomerase as a Fountain of Youth What would it mean to live forever? Rising Life Expectancy, but … Read more<\/a><\/p>\n","protected":false},"author":65,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"open","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-205","page","type-page","status-publish"],"yoast_head":"\nIndex to This Blog - Josh Mitteldorf<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/scienceblog.com\/joshmitteldorf\/index-to-this-blog\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Index to This Blog\" \/>\n<meta property=\"og:description\" content=\"Comprehensive Index of Posts to Josh Mitteldorf\u2019s Aging Blog \u00a0(2012 –\u00a0 Sept-Dec 2012 Can telomere herapies help us live longer? Vitamin D and Aspirin Is Metformin an Anti-Aging Drug? 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