{"id":1308,"date":"2025-02-01T22:14:52","date_gmt":"2025-02-01T22:14:52","guid":{"rendered":"https:\/\/joshmitteldorf.peachpuff-wolverine-566518.hostingersite.com\/?p=1308"},"modified":"2025-02-01T22:14:52","modified_gmt":"2025-02-01T22:14:52","slug":"proposal-for-enhancing-experimental-anti-aging-treatment-with-young-plasma","status":"publish","type":"post","link":"https:\/\/scienceblog.com\/joshmitteldorf\/2025\/02\/01\/proposal-for-enhancing-experimental-anti-aging-treatment-with-young-plasma\/","title":{"rendered":"Proposal for Enhancing Experimental Anti-aging Treatment with Young Plasma"},"content":{"rendered":"<p><span style=\"font-weight: 400\">Large doses of young exosomes, delivered intravenously, have been shown to have extraordinary rejuvenation power in rats. We have known this for 5 years, but translation to human trials has been slow, not for technical reasons but because of trade secrets and intellectual property law and the inability to guarantee that he who funds the translation research will profit from the finished product.<\/span><\/p>\n<p><span style=\"font-weight: 400\">In the interim, a cottage industry has developed around a weaker human therapy based on the technique that is so successful in rats. Plasma infusions are a well-developed, safe and approved procedure for trauma injury and other applications. It has been adapted by clinics in Texas as an anti-aging therapy. For some tens of thousands of dollars, an old person can buy two liters of blood plasma from a guaranteed healthy young donor.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400\">For those with the money to spend, the limit of two liters comes about because the volume of the body\u2019s circulatory system can be stretched only so much. Putting extra fluid into the system, with extra pressure on the arterial walls, can be dangerous. Typically, one liter of blood plasma can be removed and two added, for a net volume increase of one liter. (An adult might have 5 liters total, so this amounts to a 20% expansion of the blood volume.)<\/span><\/p>\n<p><span style=\"font-weight: 400\">Some people report good results from this procedure, but no one has been restored to youthful appearance, health, endurance, and learning potential comparable to the rats in the laboratories of <\/span><a href=\"https:\/\/link.springer.com\/article\/10.1007\/s11357-023-00980-6\"><span style=\"font-weight: 400\">Harold Katcher<\/span><\/a><span style=\"font-weight: 400\"> or <\/span><a href=\"https:\/\/www.nature.com\/articles\/s43587-024-00612-4\"><span style=\"font-weight: 400\">Xi Chen<\/span><\/a><span style=\"font-weight: 400\">. I\u2019m guessing this is because the exosome dosages in these rat experiments were far larger than the ~35% replacement that is achieved in the Texas clinics. I believe that Katcher and Chen both used exosome infusions large enough to overwhelm the reservoir of old exosomes in the blood of the old rat.\u00a0<\/span><\/p>\n<h2><span style=\"font-weight: 400\">Proposal for infusing larger plasma doses in human trials<\/span><\/h2>\n<p><span style=\"font-weight: 400\">Blood plasma is 90% water. If it is the water volume that limits the dosage of young plasma, an obvious work-around is to concentrate the exosomes and other plasma ingredients before infusion. Freeze dried plasma is already a well-developed technology, in use for 80 years. Under a vacuum, the plasma is evaporated and the evaporation lowers the temperature. Over the course of 10-20 hours, almost all the water is removed, and the plasma is reduced to a slurry.<\/span><\/p>\n<p><span style=\"font-weight: 400\">This technique has been developed for the convenience of long-term storage only, so that, in hospitals, plasma is routinely reconstituted to full strength before administration. But by adding less water, the plasma could be reconstituted at triple strength or more. In this way, a much larger dosage of young plasma could be infused in the old patient.<\/span><\/p>\n<h2><span style=\"font-weight: 400\">Refinements<\/span><\/h2>\n<p><span style=\"font-weight: 400\">Platelets are miniature cells responsible for blood clotting. It will be necessary to remove platelets from the plasma, because blood with 3 or 4 times the healthy concentration of platelets poses a danger of clotting, heart attack, and strokes. It may be advisable to remove albumen and some other elements of the plasma to keep their concentration within normal limits.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400\">There is an <\/span><a href=\"https:\/\/www.dobrikiprov.com\/\"><span style=\"font-weight: 400\">experimental anti-aging clinic<\/span><\/a><span style=\"font-weight: 400\"> in California, where old blood plasma is removed and replaced with albumen. It probably makes sense to remove old exosomes as we add young exosomes<\/span><\/p>\n<h2><span style=\"font-weight: 400\">We do not yet know<\/span><\/h2>\n<p><span style=\"font-weight: 400\">The principal uncertainty is whether the young exosomes are able to reprogram the body\u2019s epigenetics, with a result that is self-sustaining. If we are lucky, then the reprogrammed body will produce its own young exosomes; if we are unlucky, then infusions of young exosomes will have to be repeated, perhaps as often as the blood turns over, which is a few months; if we are very unlucky, then the infusions will have to be repeated as often as exosomes are cleared from the blood, which is less than one day, and the treatment becomes completely impractical.<\/span><\/p>\n<p><span style=\"font-weight: 400\">But results with rats suggest that the rejuvenation has some staying power.\u00a0<\/span><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Large doses of young exosomes, delivered intravenously, have been shown to have extraordinary rejuvenation power in rats. We have known this for 5 years, but translation to human trials has been slow, not for technical reasons but because of trade secrets and intellectual property law and the inability to guarantee that he who funds the &#8230; <a title=\"Proposal for Enhancing Experimental Anti-aging Treatment with Young Plasma\" class=\"read-more\" href=\"https:\/\/scienceblog.com\/joshmitteldorf\/2025\/02\/01\/proposal-for-enhancing-experimental-anti-aging-treatment-with-young-plasma\/\" aria-label=\"Read more about Proposal for Enhancing Experimental Anti-aging Treatment with Young Plasma\">Read more<\/a><\/p>\n","protected":false},"author":65,"featured_media":1309,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1308","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Proposal for Enhancing Experimental Anti-aging Treatment with Young Plasma - Josh Mitteldorf<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/scienceblog.com\/joshmitteldorf\/2025\/02\/01\/proposal-for-enhancing-experimental-anti-aging-treatment-with-young-plasma\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Proposal for Enhancing Experimental Anti-aging Treatment with Young Plasma\" \/>\n<meta property=\"og:description\" content=\"Large doses of young exosomes, delivered intravenously, have been shown to have extraordinary rejuvenation power in rats. 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Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/scienceblog.com\/joshmitteldorf\/2025\/02\/01\/proposal-for-enhancing-experimental-anti-aging-treatment-with-young-plasma\/\" \/>\n<meta property=\"og:site_name\" content=\"Josh Mitteldorf\" \/>\n<meta property=\"article:published_time\" content=\"2025-02-01T22:14:52+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/scienceblog.com\/joshmitteldorf\/wp-content\/uploads\/sites\/2\/2025\/02\/plasmapheresis.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"258\" \/>\n\t<meta property=\"og:image:height\" content=\"195\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Josh Mitteldorf\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Josh Mitteldorf\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/scienceblog.com\\\/joshmitteldorf\\\/2025\\\/02\\\/01\\\/proposal-for-enhancing-experimental-anti-aging-treatment-with-young-plasma\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/scienceblog.com\\\/joshmitteldorf\\\/2025\\\/02\\\/01\\\/proposal-for-enhancing-experimental-anti-aging-treatment-with-young-plasma\\\/\"},\"author\":{\"name\":\"Josh Mitteldorf\",\"@id\":\"https:\\\/\\\/scienceblog.com\\\/joshmitteldorf\\\/#\\\/schema\\\/person\\\/214c5d1dad9f15c48f03128d5cfccdb1\"},\"headline\":\"Proposal for Enhancing Experimental Anti-aging Treatment with Young Plasma\",\"datePublished\":\"2025-02-01T22:14:52+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/scienceblog.com\\\/joshmitteldorf\\\/2025\\\/02\\\/01\\\/proposal-for-enhancing-experimental-anti-aging-treatment-with-young-plasma\\\/\"},\"wordCount\":659,\"commentCount\":108,\"publisher\":{\"@id\":\"https:\\\/\\\/scienceblog.com\\\/joshmitteldorf\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/scienceblog.com\\\/joshmitteldorf\\\/2025\\\/02\\\/01\\\/proposal-for-enhancing-experimental-anti-aging-treatment-with-young-plasma\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/scienceblog.com\\\/joshmitteldorf\\\/wp-content\\\/uploads\\\/sites\\\/2\\\/2025\\\/02\\\/plasmapheresis.jpg\",\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/scienceblog.com\\\/joshmitteldorf\\\/2025\\\/02\\\/01\\\/proposal-for-enhancing-experimental-anti-aging-treatment-with-young-plasma\\\/#respond\"]}],\"copyrightYear\":\"2025\",\"copyrightHolder\":{\"@id\":\"https:\\\/\\\/scienceblog.com\\\/#organization\"}},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/scienceblog.com\\\/joshmitteldorf\\\/2025\\\/02\\\/01\\\/proposal-for-enhancing-experimental-anti-aging-treatment-with-young-plasma\\\/\",\"url\":\"https:\\\/\\\/scienceblog.com\\\/joshmitteldorf\\\/2025\\\/02\\\/01\\\/proposal-for-enhancing-experimental-anti-aging-treatment-with-young-plasma\\\/\",\"name\":\"Proposal for Enhancing Experimental Anti-aging Treatment with Young Plasma - 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The surprising fact that our bodies are genetically programmed to age and to die offers an enormous opportunity for medical intervention. It may be that therapies to slow the progress of aging need not repair or regenerate anything, but only need to interfere with an existing program of self-destruction. Mitteldorf has taught a weekly yoga class for thirty years. He is an advocate for vigorous self care, including exercise, meditation and caloric restriction. After earning a PhD in astrophysicist, Mitteldorf moved to evolutionary biology as a primary field in 1996. He has taught at Harvard, Berkeley, Bryn Mawr, LaSalle and Temple University. He is presently affiliated with MIT as a visiting scholar. In private life, Mitteldorf is an advocate for election integrity as well as public health. He is an avid amateur musician, playing piano in chamber groups, French horn in community orchestras. His two daughters are among the first children adopted from China in the mid-1980s. Much to the surprise of evolutionary biologists, genetic experiments indicate that aging has been selected as an adaptation for its own sake. This poses a conundrum: the impact of aging on individual fitness is wholly negative, so aging must be regarded as a kind of evolutionary altruism. Unlike other forms of evolutionary altruism, aging offers benefits to the community that are weak, and not well focussed on near kin of the altruist. This makes the mechanism challenging to understand and to model. more at http:\\\/\\\/mathforum.org\\\/~josh\",\"sameAs\":[\"http:\\\/\\\/AgingAdvice.org\"],\"url\":\"https:\\\/\\\/scienceblog.com\\\/joshmitteldorf\\\/author\\\/joshmitteldorf\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Proposal for Enhancing Experimental Anti-aging Treatment with Young Plasma - Josh Mitteldorf","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/scienceblog.com\/joshmitteldorf\/2025\/02\/01\/proposal-for-enhancing-experimental-anti-aging-treatment-with-young-plasma\/","og_locale":"en_US","og_type":"article","og_title":"Proposal for Enhancing Experimental Anti-aging Treatment with Young Plasma","og_description":"Large doses of young exosomes, delivered intravenously, have been shown to have extraordinary rejuvenation power in rats. 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The surprising fact that our bodies are genetically programmed to age and to die offers an enormous opportunity for medical intervention. It may be that therapies to slow the progress of aging need not repair or regenerate anything, but only need to interfere with an existing program of self-destruction. Mitteldorf has taught a weekly yoga class for thirty years. He is an advocate for vigorous self care, including exercise, meditation and caloric restriction. After earning a PhD in astrophysicist, Mitteldorf moved to evolutionary biology as a primary field in 1996. He has taught at Harvard, Berkeley, Bryn Mawr, LaSalle and Temple University. He is presently affiliated with MIT as a visiting scholar. In private life, Mitteldorf is an advocate for election integrity as well as public health. He is an avid amateur musician, playing piano in chamber groups, French horn in community orchestras. His two daughters are among the first children adopted from China in the mid-1980s. Much to the surprise of evolutionary biologists, genetic experiments indicate that aging has been selected as an adaptation for its own sake. This poses a conundrum: the impact of aging on individual fitness is wholly negative, so aging must be regarded as a kind of evolutionary altruism. Unlike other forms of evolutionary altruism, aging offers benefits to the community that are weak, and not well focussed on near kin of the altruist. This makes the mechanism challenging to understand and to model. more at http:\/\/mathforum.org\/~josh","sameAs":["http:\/\/AgingAdvice.org"],"url":"https:\/\/scienceblog.com\/joshmitteldorf\/author\/joshmitteldorf\/"}]}},"jetpack_featured_media_url":"https:\/\/scienceblog.com\/joshmitteldorf\/wp-content\/uploads\/sites\/2\/2025\/02\/plasmapheresis.jpg","jetpack_shortlink":"https:\/\/wp.me\/pgtN8h-l6","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/scienceblog.com\/joshmitteldorf\/wp-json\/wp\/v2\/posts\/1308","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/scienceblog.com\/joshmitteldorf\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/scienceblog.com\/joshmitteldorf\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/scienceblog.com\/joshmitteldorf\/wp-json\/wp\/v2\/users\/65"}],"replies":[{"embeddable":true,"href":"https:\/\/scienceblog.com\/joshmitteldorf\/wp-json\/wp\/v2\/comments?post=1308"}],"version-history":[{"count":0,"href":"https:\/\/scienceblog.com\/joshmitteldorf\/wp-json\/wp\/v2\/posts\/1308\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/scienceblog.com\/joshmitteldorf\/wp-json\/wp\/v2\/media\/1309"}],"wp:attachment":[{"href":"https:\/\/scienceblog.com\/joshmitteldorf\/wp-json\/wp\/v2\/media?parent=1308"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/scienceblog.com\/joshmitteldorf\/wp-json\/wp\/v2\/categories?post=1308"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/scienceblog.com\/joshmitteldorf\/wp-json\/wp\/v2\/tags?post=1308"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}