{"id":246,"date":"2014-05-05T13:33:00","date_gmt":"2014-05-05T13:33:00","guid":{"rendered":"http:\/\/joshmitteldorf.peachpuff-wolverine-566518.hostingersite.com\/?p=246"},"modified":"2014-05-05T13:44:25","modified_gmt":"2014-05-05T13:44:25","slug":"gdf11-a-hormonal-candidate-for-rejuvenation","status":"publish","type":"post","link":"https:\/\/scienceblog.com\/joshmitteldorf\/2014\/05\/05\/gdf11-a-hormonal-candidate-for-rejuvenation\/","title":{"rendered":"GDF11: A hormonal candidate for rejuvenation"},"content":{"rendered":"

I did a series last fall <\/i>[1<\/a>, 2<\/a>, 3<\/a>] on the thesis that aging is a program of self-destruction, executed under the control of hormonal signals in the blood. \u00a0If we can re-balance those signals appropriately, we will be able to revert the body to a younger age. \u00a0Maybe. \u00a0Yesterday, just in one day, three papers appeared in major journals reporting on blood factors that can reverse aging. <\/i><\/p>\n

\"\"<\/p>\n

All three papers come from a line of research called parabiosis<\/a>. \u00a0Circulatory systems of a young mouse and an old mouse are surgically joined so that the blood circulating in the veins of the old mouse comes half from the young mouse. \u00a0The finding from the Conboy Lab in 2005<\/a> is that the old mouse is rejuvenated in significant ways. \u00a0Research since then has sought to separate which factors in the blood are responsible for this effect. \u00a0Irina Conboy<\/a> told me last month she has identified 6 key molecules, some of which need to be added, others either removed or de-activated.<\/p>\n

Paper #1<\/a>: (out of Stanford and UCSF and the Palo Alto Center for Regenerative Medicine) \u201cHere we report that exposure of an aged animal to young blood can counteract and reverse pre-existing effects of brain aging at the molecular, structural, functional and cognitive level.\u201d \u00a0Exactly which chemical compounds was not determined, but the benefit was seen both in growth of new neurons in the brain, and also in oberved behavioral changes and improvements in learning among the older animals. \u00a0The mechanism was traced to biochemical effects in the hippocampus, part of the old mammalian brain that is the first to be damaged in Alzheimer\u2019s disease. \u00a0In case you\u2019re wondering how you measure cognitive behaior in a surgically-creaed Siamese twin, the answer is that the group was able to see the cognitive benefits when small amounts of the young mouse blood were injected intravenously into the old mouse, eliminating the need for surgerical pairing.<\/p>\n

The other two papers were announced in on-line news<\/a> from Science Magazine, but the original papers are embargoed until Friday. \u00a0Both involve GDF11, (for \u201cGrowth-Differentiating Factor\u201d), which is a hormone common to mice and humans. \u00a0\u201cGDF11 is naturally found in much higher concentration in young mice than in older mice, and raising its levels in the older mice has improved the function of every organ system thus far studied.\u201d [Doug Melton of Harvard, quoted in Science Daily<\/a>]<\/p>\n

Paper #2<\/a>: (from Lee Rubin\u2019s group<\/a> at Harvard) Improvement in l earning behavior and increase in new neurons were both noted with injections of GDF11. “Regardless of the age of the old brain . . . young blood is still able to rejuvenate the aged brain.\u201d \u00a0\u201cWe do think that, at least in principle, there will be a way to reverse some of the cognitive decline that takes place during aging, perhaps even with a single protein. It could be that a molecule like GDF 11, or GDF 11 itself, could” reverse the damage of aging.\u201d [quoted in Science 2.0<\/a>]<\/p>\n

Paper #3<\/a>: (from Amy Wager\u2019s group<\/a> at Harvard) also used GDF11, and demonstrates improvements in healing and in muscle growth and strength. \u201cInjections of GDF11 can reduce the thickening of the heart that typically comes with aging in mice…GDF11 works nearly as well as parabiosis in helping aging mice recover from a muscle injury and boosts their performance on running and grip strength tests.\u201d<\/p>\n

When dramatic results like this, indicating that some simple intervention is capable of turning back the aging clock, the question everyone avoids asking is, “Why isn’t the body doing this on its own?” \u00a0The answer, of course, is that the body doesn’t want to. \u00a0The body is programmed in its genes to age and die<\/a>, but to acknowledge this is to precipitate a revolution in our understanding of the fundamental mechanisms of evolutionary biology.<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

I did a series last fall [1, 2, 3] on the thesis that aging is a program of self-destruction, executed under the control of hormonal signals in the blood. \u00a0If we can re-balance those signals appropriately, we will be able to revert the body to a younger age. \u00a0Maybe. \u00a0Yesterday, just in one day, three … Read more<\/a><\/p>\n","protected":false},"author":65,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[1],"tags":[],"class_list":["post-246","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"\nGDF11: A hormonal candidate for rejuvenation - Josh Mitteldorf<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/scienceblog.com\/joshmitteldorf\/2014\/05\/05\/gdf11-a-hormonal-candidate-for-rejuvenation\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"GDF11: A hormonal candidate for rejuvenation\" \/>\n<meta property=\"og:description\" content=\"I did a series last fall [1, 2, 3] on the thesis that aging is a program of self-destruction, executed under the control of hormonal signals in the blood. \u00a0If we can re-balance those signals appropriately, we will be able to revert the body to a younger age. \u00a0Maybe. \u00a0Yesterday, just in one day, three ... 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The surprising fact that our bodies are genetically programmed to age and to die offers an enormous opportunity for medical intervention. It may be that therapies to slow the progress of aging need not repair or regenerate anything, but only need to interfere with an existing program of self-destruction. Mitteldorf has taught a weekly yoga class for thirty years. He is an advocate for vigorous self care, including exercise, meditation and caloric restriction. After earning a PhD in astrophysicist, Mitteldorf moved to evolutionary biology as a primary field in 1996. He has taught at Harvard, Berkeley, Bryn Mawr, LaSalle and Temple University. He is presently affiliated with MIT as a visiting scholar. In private life, Mitteldorf is an advocate for election integrity as well as public health. He is an avid amateur musician, playing piano in chamber groups, French horn in community orchestras. His two daughters are among the first children adopted from China in the mid-1980s. Much to the surprise of evolutionary biologists, genetic experiments indicate that aging has been selected as an adaptation for its own sake. This poses a conundrum: the impact of aging on individual fitness is wholly negative, so aging must be regarded as a kind of evolutionary altruism. Unlike other forms of evolutionary altruism, aging offers benefits to the community that are weak, and not well focussed on near kin of the altruist. 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The surprising fact that our bodies are genetically programmed to age and to die offers an enormous opportunity for medical intervention. It may be that therapies to slow the progress of aging need not repair or regenerate anything, but only need to interfere with an existing program of self-destruction. Mitteldorf has taught a weekly yoga class for thirty years. He is an advocate for vigorous self care, including exercise, meditation and caloric restriction. After earning a PhD in astrophysicist, Mitteldorf moved to evolutionary biology as a primary field in 1996. He has taught at Harvard, Berkeley, Bryn Mawr, LaSalle and Temple University. He is presently affiliated with MIT as a visiting scholar. In private life, Mitteldorf is an advocate for election integrity as well as public health. He is an avid amateur musician, playing piano in chamber groups, French horn in community orchestras. His two daughters are among the first children adopted from China in the mid-1980s. Much to the surprise of evolutionary biologists, genetic experiments indicate that aging has been selected as an adaptation for its own sake. This poses a conundrum: the impact of aging on individual fitness is wholly negative, so aging must be regarded as a kind of evolutionary altruism. Unlike other forms of evolutionary altruism, aging offers benefits to the community that are weak, and not well focussed on near kin of the altruist. This makes the mechanism challenging to understand and to model. more at http:\/\/mathforum.org\/~josh","sameAs":["http:\/\/AgingAdvice.org"],"url":"https:\/\/scienceblog.com\/joshmitteldorf\/author\/joshmitteldorf\/"}]}},"jetpack_featured_media_url":"","jetpack_shortlink":"https:\/\/wp.me\/pgtN8h-3Y","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/scienceblog.com\/joshmitteldorf\/wp-json\/wp\/v2\/posts\/246","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/scienceblog.com\/joshmitteldorf\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/scienceblog.com\/joshmitteldorf\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/scienceblog.com\/joshmitteldorf\/wp-json\/wp\/v2\/users\/65"}],"replies":[{"embeddable":true,"href":"https:\/\/scienceblog.com\/joshmitteldorf\/wp-json\/wp\/v2\/comments?post=246"}],"version-history":[{"count":0,"href":"https:\/\/scienceblog.com\/joshmitteldorf\/wp-json\/wp\/v2\/posts\/246\/revisions"}],"wp:attachment":[{"href":"https:\/\/scienceblog.com\/joshmitteldorf\/wp-json\/wp\/v2\/media?parent=246"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/scienceblog.com\/joshmitteldorf\/wp-json\/wp\/v2\/categories?post=246"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/scienceblog.com\/joshmitteldorf\/wp-json\/wp\/v2\/tags?post=246"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}