{"id":476,"date":"2016-04-04T21:40:27","date_gmt":"2016-04-04T21:40:27","guid":{"rendered":"http:\/\/joshmitteldorf.peachpuff-wolverine-566518.hostingersite.com\/?p=476"},"modified":"2016-04-04T21:41:33","modified_gmt":"2016-04-04T21:41:33","slug":"politics-drives-a-promising-nutraceutical-underground","status":"publish","type":"post","link":"https:\/\/scienceblog.com\/joshmitteldorf\/2016\/04\/04\/politics-drives-a-promising-nutraceutical-underground\/","title":{"rendered":"Politics Drives a Promising Nutraceutical Underground"},"content":{"rendered":"<p><em>The plural of \u201canecdote\u201d is \u201cdata\u201d. \u00a0When Anatabloc was taken off the market two years ago, customers bemoaned the loss of the only product they had ever found that relieved their arthritic symptoms. \u00a0One of them contacted me through this blog, and told me that before it disappeared, he stockpiled three years\u2019 inventory, which he is still taking now.<\/em><\/p>\n<p>Anatabine is a naturally-occurring chemical constituent of eggplant, tomatoes and (especially) tobacco. \u00a0The chemical structure is similar to nicotine<\/p>\n<p><a href=\"https:\/\/2e9be637a5b4415c18c5-5ddb36df15af65ab8482e83373c53fe5.ssl.cf1.rackcdn.com\/images\/371.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter\" src=\"https:\/\/2e9be637a5b4415c18c5-5ddb36df15af65ab8482e83373c53fe5.ssl.cf1.rackcdn.com\/images\/371.png\" alt=\"\" width=\"698\" height=\"189\" \/><\/a><\/p>\n<p>Anatabine is interesting because<\/p>\n<ul>\n<li>Inflammation is one of the primary means by which the body self-destructs as we get older.<\/li>\n<li><a href=\"https:\/\/scienceblog.com\/joshmitteldorf\/2013\/11\/12\/molecules-in-the-blood-that-signal-self-destruction\/\">NF\u03baB<\/a> is the best-known pro-inflammatory hormone that increases with age, to our detriment.<\/li>\n<li>Anatabine is reported to block the action of NF\u03baB.<\/li>\n<\/ul>\n<p>Beginning more than 10 years ago, anatabine was promoted by Star Scientific Co as a nutraceutical under their trade name, Anatabloc. \u00a0Impatient with the steady rise of sales, Johnnie Williams of Star Sci used political influence with Virginia\u2019s Gov Bob McDonnell to get Medicaid to pay for anatabine as a drug. \u00a0A <a href=\"http:\/\/www.nytimes.com\/2014\/01\/22\/us\/former-virginia-governor-and-his-wife-are-indicted.html\">scandal two years ago<\/a> brought down Williams and McDonnell both. \u00a0(<a href=\"http:\/\/www.cc.com\/video-clips\/9x6g2h\/the-daily-show-with-jon-stewart-the-giving-spree\">Jon Stewart skewered<\/a> the story at the time, and though his take on the politics may be well-grounded, his implication that any chemical found in tobacco must be poison is silly.) \u00a0Anatabine was dragged down with the two, and now research on a promising chemical is foundering. \u00a0Anatabine is no longer available for purchase in the America or Europe.<\/p>\n<p>In the <a href=\"http:\/\/press.endocrine.org\/doi\/abs\/10.1210\/jc.2013-2951\">only published clinical study<\/a> of anatabine, it was found useful for an obscure auto-immune syndrome of the thyroid. \u00a0In the government web site <a href=\"https:\/\/clinicaltrials.gov\/ct2\/results?term=anatabine&amp;Search=Search\">ClinicalTrials.gov<\/a>, there are three more completed trials for which I was unable to find publications as yet. \u00a0The most interesting relates to the effect of anatabine on C-Reactive Protein in the blood, which is a well-established marker of inflammation. \u00a0That study was conducted by <a href=\"https:\/\/www.youtube.com\/watch?v=pZhZyeDAAhw\">Michael Mullan of Roskamp Inst<\/a>. \u00a0In <a href=\"https:\/\/www.youtube.com\/watch?v=pZhZyeDAAhw\">this video<\/a>, he reviews a mouse study suggesting anatabine might be useful for slowing progress of Alzheimer\u2019s Disease. \u00a0Psoriasis is another disease of inflammation gone awry for which it may be useful, and <a href=\"http:\/\/biotuesdays.com\/2015\/10\/20\/maxim-starts-rock-creek-pharma-at-buy\/\">reportedly<\/a> Rock Creek Pharmaceuticals is banking on psoriasis for their first clinical approval, from which they might leverage research on other applications. \u00a0<a href=\"https:\/\/www.google.com\/patents\/US6534527\">Smoking cessation<\/a> is another promising early application. \u00a0But in the long run, Rock Creek scientists have their sights set on <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26010758\">Alzheimer\u2019s Disease<\/a>. \u00a0(I\u2019ve been unable to raise a response from Rock Creek\u2019s principal scientists to find out more.)<\/p>\n<p> <b>What\u2019s the evidence for blocking NF\u03baB?<\/b><\/p>\n<p>These three studies [<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23383175\">1<\/a>, <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23178521\">2<\/a>, <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23178521\">3<\/a>] all claim to observe that NF<span style=\"font-family: symbol\">k<\/span>B activity is lower in mice taking anatabine. \u00a0The mechanism is to block phosphorylation of NFkB, which is an energizing stage in the biochemistry that initiates its activity. \u00a0Dosages were injected, at 2mg\/kg. \u00a0These studies followed from cell studies <i>in vitro<\/i> observing the same chemistry.<\/p>\n<p>All studies come from the same team of scientists, associated with RockCreek Pharma and the Rosskamp Inst, both in Tampa, FL. \u00a0I wish there were independent groups replicating their findings, and I suspect that it is the political scandal that has driven them away.<\/p>\n<p>I learned from <a href=\"https:\/\/examine.com\/supplements\/anatabine\/\">Examine.com<\/a> of two more herbs that block NFkB, to wit Boswellia (frankinicense) and Feverfew.<\/p>\n<p>&nbsp;<\/p>\n<p><b>Dosage<\/b><\/p>\n<p>Anatabloc contained a dosage of only 1mg per pill, but rodent studies suggest that the effective human dosage is likely to be at least 10 times higher than that.<\/p>\n<p>&nbsp;<\/p>\n<p><b>Safety, and the Bottom Line<\/b><\/p>\n<p>Reported side-effects of anatabine include headache and stomachache. \u00a0Perhaps this is why the dosage in Anatabloc was kept so low. \u00a0Rock Creek\u00a0Pharma\u00a0claims that a phase-1 trial of oral anatabine\u00a0found no side effects, but <a href=\"http:\/\/www.amazon.com\/review\/R33VCR5L8VEOZH\">anecdotal evidence<\/a> suggests that some people have serious responses.<\/p>\n<p>The best evidence we have may be from a user survey conducted by scientists affiliated with Rock Creek, and written up as a <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3825642\/\">journal article<\/a>.<\/p>\n<blockquote><p>Of the 78 respondents who stopped taking the supplement for some period of time for any reason, 83% experienced a noticeable return of their joint pain symptoms. Forty-four of 65 (68%) respondents indicated that their symptoms returned within 2\u20133 days or less, and 64 of 65 (98%) indicated that their symptoms returned within one week or less (<a class=\"fig-table-link fig figpopup\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3825642\/figure\/f3-cmamd-6-2013-073\/\" target=\"figure\">Fig. 3<\/a>). Almost all of the respondents (64 of 65, or 98%) who had stopped using anatabine and felt their joint pain symptoms return subsequently felt those symptoms decrease once they resumed using the supplement.<\/p><\/blockquote>\n<p>The survey indicates a lot of satisfied customers, but does not touch on the issues of dosage or side-effects.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The plural of \u201canecdote\u201d is \u201cdata\u201d. \u00a0When Anatabloc was taken off the market two years ago, customers bemoaned the loss of the only product they had ever found that relieved their arthritic symptoms. \u00a0One of them contacted me through this blog, and told me that before it disappeared, he stockpiled three years\u2019 inventory, which he &#8230; <a title=\"Politics Drives a Promising Nutraceutical Underground\" class=\"read-more\" href=\"https:\/\/scienceblog.com\/joshmitteldorf\/2016\/04\/04\/politics-drives-a-promising-nutraceutical-underground\/\" aria-label=\"Read more about Politics Drives a Promising Nutraceutical Underground\">Read more<\/a><\/p>\n","protected":false},"author":65,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[1],"tags":[],"class_list":["post-476","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.5 (Yoast SEO v27.5) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Politics Drives a Promising Nutraceutical Underground - Josh Mitteldorf<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/scienceblog.com\/joshmitteldorf\/2016\/04\/04\/politics-drives-a-promising-nutraceutical-underground\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Politics Drives a Promising Nutraceutical Underground\" \/>\n<meta property=\"og:description\" content=\"The plural of \u201canecdote\u201d is \u201cdata\u201d. \u00a0When Anatabloc was taken off the market two years ago, customers bemoaned the loss of the only product they had ever found that relieved their arthritic symptoms. \u00a0One of them contacted me through this blog, and told me that before it disappeared, he stockpiled three years\u2019 inventory, which he ... 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The surprising fact that our bodies are genetically programmed to age and to die offers an enormous opportunity for medical intervention. It may be that therapies to slow the progress of aging need not repair or regenerate anything, but only need to interfere with an existing program of self-destruction. Mitteldorf has taught a weekly yoga class for thirty years. He is an advocate for vigorous self care, including exercise, meditation and caloric restriction. After earning a PhD in astrophysicist, Mitteldorf moved to evolutionary biology as a primary field in 1996. He has taught at Harvard, Berkeley, Bryn Mawr, LaSalle and Temple University. He is presently affiliated with MIT as a visiting scholar. In private life, Mitteldorf is an advocate for election integrity as well as public health. He is an avid amateur musician, playing piano in chamber groups, French horn in community orchestras. His two daughters are among the first children adopted from China in the mid-1980s. Much to the surprise of evolutionary biologists, genetic experiments indicate that aging has been selected as an adaptation for its own sake. This poses a conundrum: the impact of aging on individual fitness is wholly negative, so aging must be regarded as a kind of evolutionary altruism. Unlike other forms of evolutionary altruism, aging offers benefits to the community that are weak, and not well focussed on near kin of the altruist. This makes the mechanism challenging to understand and to model. more at http:\\\/\\\/mathforum.org\\\/~josh\",\"sameAs\":[\"http:\\\/\\\/AgingAdvice.org\"],\"url\":\"https:\\\/\\\/scienceblog.com\\\/joshmitteldorf\\\/author\\\/joshmitteldorf\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Politics Drives a Promising Nutraceutical Underground - Josh Mitteldorf","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/scienceblog.com\/joshmitteldorf\/2016\/04\/04\/politics-drives-a-promising-nutraceutical-underground\/","og_locale":"en_US","og_type":"article","og_title":"Politics Drives a Promising Nutraceutical Underground","og_description":"The plural of \u201canecdote\u201d is \u201cdata\u201d. \u00a0When Anatabloc was taken off the market two years ago, customers bemoaned the loss of the only product they had ever found that relieved their arthritic symptoms. \u00a0One of them contacted me through this blog, and told me that before it disappeared, he stockpiled three years\u2019 inventory, which he ... 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The surprising fact that our bodies are genetically programmed to age and to die offers an enormous opportunity for medical intervention. It may be that therapies to slow the progress of aging need not repair or regenerate anything, but only need to interfere with an existing program of self-destruction. Mitteldorf has taught a weekly yoga class for thirty years. He is an advocate for vigorous self care, including exercise, meditation and caloric restriction. After earning a PhD in astrophysicist, Mitteldorf moved to evolutionary biology as a primary field in 1996. He has taught at Harvard, Berkeley, Bryn Mawr, LaSalle and Temple University. He is presently affiliated with MIT as a visiting scholar. In private life, Mitteldorf is an advocate for election integrity as well as public health. He is an avid amateur musician, playing piano in chamber groups, French horn in community orchestras. His two daughters are among the first children adopted from China in the mid-1980s. Much to the surprise of evolutionary biologists, genetic experiments indicate that aging has been selected as an adaptation for its own sake. This poses a conundrum: the impact of aging on individual fitness is wholly negative, so aging must be regarded as a kind of evolutionary altruism. Unlike other forms of evolutionary altruism, aging offers benefits to the community that are weak, and not well focussed on near kin of the altruist. 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