{"id":261,"date":"2020-01-13T19:09:38","date_gmt":"2020-01-13T19:09:38","guid":{"rendered":"http:\/\/niaaa.peachpuff-wolverine-566518.hostingersite.com\/?p=261"},"modified":"2020-01-13T19:09:38","modified_gmt":"2020-01-13T19:09:38","slug":"study-identifies-genetic-variant-that-may-contribute-to-alcohol-and-drug-addiction","status":"publish","type":"post","link":"https:\/\/scienceblog.com\/niaaa\/261\/study-identifies-genetic-variant-that-may-contribute-to-alcohol-and-drug-addiction\/","title":{"rendered":"Study Identifies Genetic Variant that May Contribute to Alcohol and Drug Addiction"},"content":{"rendered":"<p>People with a genetic variant of a neurotransmitter gene may have an increased risk of addiction to alcohol and other substances later in life if they were exposed to childhood stress, such as divorce or emotionally distant parents, and other adverse experiences, according to recent research.<\/p>\n<p>The study led by researchers at the University of Oklahoma College of Medicine in collaboration with researchers from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), part of the National Institutes of Health, focused on an inherited variant of the gene for the enzyme catechol\u2010O\u2010methyltransferase (<em>COMT<\/em>).\u00a0 \u201cThis is a well-known genetic variant of COMT, common worldwide, that leads to lower activity of this enzyme, and that has been previously observed to alter brain responses to stress and cognitive challenges,\u201d stated study co-author, David Goldman, M.D., Chief of NIAAA\u2019s Laboratory of Neurogenetics. <em>COMT<\/em> does so by helping the body manage levels of neurotransmitters, including dopamine, that are released when a person drinks alcohol or takes a drug like amphetamine.<\/p>\n<p>The study included 480 healthy young adults ages 18\u201330 years of age who had experienced varying amounts of early-life adversity during childhood and adolescence. The researchers found that people who experienced early life stress and had the genetically less active COMT variant were more vulnerable and started drinking at a younger age. This heightened vulnerability often led to consumption of alcohol and illicit drugs prior to the age of 15 years, a predictor for alcohol and other substance use disorders in later life.<\/p>\n<p>These findings demonstrate the interplay between a person\u2019s genetic makeup and adverse environmental factors during childhood to alter the risk of alcohol and other substance use disorders later in life. Although no single gene alone strongly predicts risk of addiction, some genes predict risk more strongly in the context of environmental exposures.<\/p>\n<p>Reference:<\/p>\n<p>Lovallo WR, Cohoon AJ, Sorocco KH, Vincent AS, Acheson A, Hodgkinson CA, Goldman D. (2019) Early-life adversity and blunted stress reactivity as predictors of alcohol and drug use in persons with <em>COMT <\/em>(rs4680) Val158Met genotypes. Alcohol Clin Exp Res. 43(7):1519-1527. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31150143\">PMID: 31150143 <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>People with a genetic variant of a neurotransmitter gene may have an increased risk of addiction to alcohol and other substances later in life if they were exposed to childhood stress, such as divorce or emotionally distant parents, and other adverse experiences, according to recent research. The study led by researchers at the University of &#8230; <a title=\"Study Identifies Genetic Variant that May Contribute to Alcohol and Drug Addiction\" class=\"read-more\" href=\"https:\/\/scienceblog.com\/niaaa\/261\/study-identifies-genetic-variant-that-may-contribute-to-alcohol-and-drug-addiction\/\" aria-label=\"Read more about Study Identifies Genetic Variant that May Contribute to Alcohol and Drug Addiction\">Read more<\/a><\/p>\n","protected":false},"author":336,"featured_media":262,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"generate_page_header":"","jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[53],"tags":[34,27,67,29,28,68],"class_list":["post-261","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-news","tag-addiction","tag-alcohol","tag-genetics","tag-national-institute-on-alcohol-abuse-and-alcoholism","tag-niaaa","tag-stress"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Study Identifies Genetic Variant that May Contribute to Alcohol and Drug Addiction - News from the National Institute on Alcohol Abuse and Alcoholism<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/scienceblog.com\/niaaa\/261\/study-identifies-genetic-variant-that-may-contribute-to-alcohol-and-drug-addiction\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Study Identifies Genetic Variant that May Contribute to Alcohol and Drug Addiction\" \/>\n<meta property=\"og:description\" content=\"People with a genetic variant of a neurotransmitter gene may have an increased risk of addiction to alcohol and other substances later in life if they were exposed to childhood stress, such as divorce or emotionally distant parents, and other adverse experiences, according to recent research. 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