{"id":409,"date":"2022-05-13T18:36:29","date_gmt":"2022-05-13T18:36:29","guid":{"rendered":"https:\/\/niaaa.peachpuff-wolverine-566518.hostingersite.com\/?p=409"},"modified":"2022-05-13T18:36:29","modified_gmt":"2022-05-13T18:36:29","slug":"niaaa-fosters-innovation-through-its-small-business-research-program","status":"publish","type":"post","link":"https:\/\/scienceblog.com\/niaaa\/409\/niaaa-fosters-innovation-through-its-small-business-research-program\/","title":{"rendered":"NIAAA Fosters Innovation Through Its Small Business Research Program"},"content":{"rendered":"<p class=\"intro\">The Small Business Innovation Research (SBIR) and Small Business Technology Transfer Research (STTR) program supports the development and commercialization of innovative tools, technologies, and strategies. The\u00a0<a id=\"anch_27\" href=\"https:\/\/www.niaaa.nih.gov\/research\/niaaa-sbir\" target=\"_blank\" rel=\"noopener noreferrer\">National Institute on Alcohol Abuse and Alcoholism (NIAAA) SBIR\/STTR program<\/a>\u00a0aims to improve the diagnosis, prevention, and treatment\u2014as well as recovery from\u2014alcohol-related problems. The SBIR\/STTR program enhances NIAAA\u2019s research portfolio across the spectrum of basic, translational, and clinical research. This portfolio includes research on medications development, alcohol biosensors, screening and diagnostic tools, educational resources, mobile apps, and more.<\/p>\n<p>\u201cEstablished by Congress as a federal-wide effort, the SBIR\/STTR program is an important component of the NIAAA research portfolio, with set-aside funds to advance innovative solutions out of the laboratory into mainstream use,\u201d reflects NIAAA Director George F. Koob, Ph.D.<\/p>\n<h2 class=\"article-title\">What Makes the SBIR\/STTR Program Unique?<\/h2>\n<p>The SBIR\/STTR program is also known as America\u2019s Seed Fund. It provides support to early-stage small businesses to meet the nation\u2019s research and development needs in a manner that stimulates innovation, encourages entrepreneurship, and contributes to the national economy. In turn, those research and development efforts increase the likelihood that publicly supported private-sector research gains will be commercialized for the benefit of the American people.<\/p>\n<p>\u201cThe SBIR\/STTR program provides an incentive for researchers who have innovative ideas and have completed successful R01 grants to try out being an entrepreneur. It de-risks the transition from academia to small business ownership,\u201d adds Megan Ryan, M.B.A., who has served as NIAAA\u2019s SBIR\/STTR Program Coordinator since 2016.<\/p>\n<p>Prioritizing project support is essential for early-stage small business viability. Throughout the years, small businesses have leveraged the support provided through the SBIR\/STTR program to advance products that show promise but are deemed a lower priority given limited resources.<\/p>\n<p>An example is the development of Vivitrol, a long-acting, injectable form of naltrexone that received U.S. Food and Drug Administration (FDA) approval for alcohol use disorder (AUD) treatment in 2006. Alkermes, at the time a small business biopharmaceutical company specializing in drug delivery technology, was awarded an NIAAA SBIR contract in 2000 to conduct proof-of-concept and efficacy clinical trials of Vivitrol. The SBIR award effectively took the risk out of development and helped Alkermes leverage the award to raise additional financial support and conduct larger clinical trials, ultimately providing the data needed for FDA approval.<\/p>\n<h2 class=\"article-title\">Increasing the Visibility of the NIAAA SBIR\/STTR Program<\/h2>\n<p>In recent years, NIAAA has focused on enhancing its SBIR\/STTR portfolio. This effort has largely focused on raising awareness of NIAAA\u2019s SBIR\/STTR program and educating entrepreneurs on how to apply for an NIAAA SBIR\/STTR award.<\/p>\n<p>To accomplish this, Ms. Ryan teamed up with a marketing company that specializes in science and healthcare to expand NIAAA\u2019s outreach about its SBIR\/STTR program. Together, they developed new outreach materials, expanded the NIAAA SBIR\/STTR website, and held informational webinars with small business incubators and \u201cstate bios.\u201d State bios are organizations that bring together a state\u2019s bioscience companies, universities, research institutions, and others dedicated to advancing life science research and commercialization. These efforts contributed to a 33 percent increase in the total number of SBIR\/STTR applications received by NIAAA within a year. Despite research setbacks common in the COVID-19 pandemic, NIAAA has continued to receive an increased number of SBIR\/STTR applications.<\/p>\n<p>\u201cThese results demonstrate the importance of outreach to potential applicants, which will remain a focus of NIAAA\u2019s SBIR\/STTR program moving forward,\u201d says Jenica Patterson, Ph.D., NIAAA\u2019s incoming SBIR\/STTR Program Coordinator.<\/p>\n<h2 class=\"article-title\">NIAAA SBIR\/STTR Program Priority Highlights<\/h2>\n<p>One of the program priorities of the NIAAA SBIR\/STTR program is developing wearable biosensors to detect the amount of alcohol an individual has consumed. Researchers are using innovative techniques to improve the accuracy of the devices as well as their wearability. This work will allow researchers to better measure alcohol consumption in clinical research studies and treatment settings.<\/p>\n<p>Another priority is the development of new medications to treat alcohol-related consequences and conditions, such as AUD, alcohol-associated organ damage (AAOD), alcohol withdrawal, and alcohol overdose. An example of\u00a0<a id=\"anch_28\" href=\"https:\/\/reporter.nih.gov\/search\/0u4ykZHaOkmWs3KG7egLHQ\/project-details\/10139179\" target=\"_blank\" rel=\"noopener noreferrer\">an NIAAA-supported SBIR project<\/a>, led by Felix Moser, Ph.D., at Synlife Bio, is the development of a novel therapeutic injection to counteract alcohol overdose. Billions of dollars are spent annually to treat alcohol overdose cases, many of which result in death\u2014yet there are no FDA-approved pharmacological treatments. NIAAA\u2019s commitment to developing new medications is emphasized by a recent SBIR\/STTR\u00a0<a id=\"anch_29\" href=\"https:\/\/grants.nih.gov\/grants\/guide\/pa-files\/PAR-22-102.html\" target=\"_blank\" rel=\"noopener noreferrer\">funding announcement<\/a>, and is an important step in bridging the gap between basic research and clinical trials.<\/p>\n<p>Improving diagnostics for AAOD is another area of interest for NIAAA\u2019s SBIR\/STTR program. For example, InLighta BioSciences, a company started by Jenny Yang, Ph.D., has developed a novel contrast agent for magnetic resonance imaging (MRI) that significantly improves diagnostic ability for conditions such as liver disease. Unlike traditional contrast agents,\u00a0<a id=\"anch_30\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30710270\/\" target=\"_blank\" rel=\"noopener noreferrer\">this agent is non-toxic and can detect early stages of disease<\/a>. From the beginning, this technology was poised to provide\u00a0<a id=\"anch_31\" href=\"https:\/\/reporter.nih.gov\/search\/-YBPOqtaA02LYdGGS9qccw\/project-details\/9971410\" target=\"_blank\" rel=\"noopener noreferrer\">a non-invasive early diagnostic tool for liver disease<\/a>\u2014a disease in which alcohol misuse is a major risk factor. In the United States, nearly half of liver disease deaths are associated with alcohol misuse.<\/p>\n<p>NIAAA\u2019s SBIR\/STTR program also supports the development of alcohol prevention programs, educational services, behavioral treatment programs, and digital health technologies. In\u00a0<a id=\"anch_32\" href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04581499\" target=\"_blank\" rel=\"noopener noreferrer\">one ongoing NIAAA-supported clinical trial<\/a>, DynamiCare Health is testing a smartphone-based digital coaching program to support accessible and affordable long-term recovery from AUD. The program is based on behavioral techniques such as contingency management, recovery coaching, and cognitive behavioral therapy.<\/p>\n<h2 class=\"article-title\">Learn More<\/h2>\n<p>For more information about the NIAAA SBIR\/STTR program, visit the NIAAA SBIR\/STTR\u00a0<a id=\"anch_33\" href=\"https:\/\/www.niaaa.nih.gov\/research\/niaaa-sbir\" target=\"_blank\" rel=\"noopener noreferrer\">website<\/a>.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>References:<\/strong><br \/>\nNIAAA SBIR\/STTR Program. Available at\u00a0<a id=\"anch_34\" href=\"https:\/\/www.niaaa.nih.gov\/research\/niaaa-sbir\" target=\"_blank\" rel=\"noopener noreferrer\">https:\/\/www.niaaa.nih.gov\/research\/niaaa-sbir<\/a>. Accessed March 16, 2022.<\/p>\n<p>NIH. A liposomal enzyme system for removal of ethanol from the blood. Available at\u00a0<a id=\"anch_35\" href=\"https:\/\/reporter.nih.gov\/search\/0u4ykZHaOkmWs3KG7egLHQ\/project-details\/10139179\" target=\"_blank\" rel=\"noopener noreferrer\">https:\/\/reporter.nih.gov\/search\/0u4ykZHaOkmWs3KG7egLHQ\/project-details\/10139179<\/a>. Accessed March 16, 2022.<\/p>\n<p>NIH. Investigational New Drug (IND)-enabling and Early-Stage Development of Medications to Treat Alcohol Use disorder and Alcohol-Associated Organ Damage (U43\/U44 Clinical Trial Optional). Available at\u00a0<a id=\"anch_36\" href=\"https:\/\/grants.nih.gov\/grants\/guide\/pa-files\/PAR-22-102.html\" target=\"_blank\" rel=\"noopener noreferrer\">https:\/\/grants.nih.gov\/grants\/guide\/pa-files\/PAR-22-102.html<\/a>. Accessed March 16, 2022.<\/p>\n<p>Salarian, M; Xue, S.; Ibhagui, O.Y.; and Yang, J.J. Designing calcium-binding proteins for molecular MR imaging.\u00a0<em>Methods in Molecular Biology<\/em>. 2019;1929:111\u2013125.\u00a0<a id=\"anch_37\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30710270\/\" target=\"_blank\" rel=\"noopener noreferrer\">PMID: 30710270<\/a><\/p>\n<p>NIH. Detecting and staging of liver fibrosis by precise MRI (pMRI). Available at\u00a0<a id=\"anch_38\" href=\"https:\/\/reporter.nih.gov\/search\/-YBPOqtaA02LYdGGS9qccw\/project-details\/9971410\" target=\"_blank\" rel=\"noopener noreferrer\">https:\/\/reporter.nih.gov\/search\/-YBPOqtaA02LYdGGS9qccw\/project-details\/9971410<\/a>. Accessed May 2, 2022.<\/p>\n<p>National Library of Medicine. Tech-Enabled CM for AUD at Scale in Medicaid. Available at\u00a0<a id=\"anch_39\" href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04581499\" target=\"_blank\" rel=\"noopener noreferrer\">https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04581499<\/a>. Accessed March 16, 2022.<\/p>\n<hr \/>\n<p><em>This article first appeared in\u00a0<a href=\"https:\/\/www.spectrum.niaaa.nih.gov\/\">NIAAA Spectrum<\/a>.<\/em><\/p>\n<p><em>To receive email alerts from NIAAA, sign up at\u00a0<a href=\"https:\/\/public.govdelivery.com\/accounts\/USNIAAA\/subscriber\/new\">https:\/\/public.govdelivery.com\/accounts\/USNIAAA\/subscriber\/new<\/a>.<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The Small Business Innovation Research (SBIR) and Small Business Technology Transfer Research (STTR) program supports the development and commercialization of innovative tools, technologies, and strategies. The\u00a0National Institute on Alcohol Abuse and Alcoholism (NIAAA) SBIR\/STTR program\u00a0aims to improve the diagnosis, prevention, and treatment\u2014as well as recovery from\u2014alcohol-related problems. The SBIR\/STTR program enhances NIAAA\u2019s research portfolio across &#8230; <a title=\"NIAAA Fosters Innovation Through Its Small Business Research Program\" class=\"read-more\" href=\"https:\/\/scienceblog.com\/niaaa\/409\/niaaa-fosters-innovation-through-its-small-business-research-program\/\" aria-label=\"Read more about NIAAA Fosters Innovation Through Its Small Business Research Program\">Read more<\/a><\/p>\n","protected":false},"author":336,"featured_media":410,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"generate_page_header":"","jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[3],"tags":[27,42],"class_list":["post-409","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-features","tag-alcohol","tag-alcohol-treatment"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>NIAAA Fosters Innovation Through Its Small Business Research Program - News from the National Institute on Alcohol Abuse and Alcoholism<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/scienceblog.com\/niaaa\/409\/niaaa-fosters-innovation-through-its-small-business-research-program\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"NIAAA Fosters Innovation Through Its Small Business Research Program\" \/>\n<meta property=\"og:description\" content=\"The Small Business Innovation Research (SBIR) and Small Business Technology Transfer Research (STTR) program supports the development and commercialization of innovative tools, technologies, and strategies. 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