{"id":67,"date":"2025-04-24T13:31:19","date_gmt":"2025-04-24T20:31:19","guid":{"rendered":"https:\/\/scienceblog.com\/sciencechina\/?p=67"},"modified":"2025-04-24T13:31:19","modified_gmt":"2025-04-24T20:31:19","slug":"mice-show-empathy-help-unconscious-friends","status":"publish","type":"post","link":"https:\/\/scienceblog.com\/sciencechina\/2025\/04\/24\/mice-show-empathy-help-unconscious-friends\/","title":{"rendered":"Mice Show Empathy, Help Unconscious Friends"},"content":{"rendered":"<p>Scientists have discovered that mice naturally help their unconscious companions without any training or rewards, challenging long-held assumptions about animal altruism and revealing surprising parallels between rodent and human social behavior.<\/p>\n<p>When placed near an anesthetized mouse, observer mice show clear signs of distress and quickly begin grooming and licking their unconscious companions. This behavior not only accelerates the recovery of the anesthetized mouse but also reduces the helper&#8217;s own stress levels, according to research published April 23 in the <em><a href=\"https:\/\/www.pnas.org\/doi\/10.1073\/pnas.2423374122\">Proceedings of the National Academy of Sciences<\/a><\/em>.<\/p>\n<p>The study marks the first time scientists have mapped the exact brain pathways responsible for this spontaneous helping behavior in mice, potentially illuminating the biological roots of empathy across species.<\/p>\n<p>&#8220;This study reveals that mice exhibit spontaneous rescue-like behavior, facilitating the recovery of anesthetized conspecifics without prior training or external rewards,&#8221; the researchers write in their paper.<\/p>\n<p>While altruistic behaviors have been well documented in larger mammals like elephants and dogs, and even in insects like ants, evidence for such tendencies in rodents has remained controversial until now.<\/p>\n<p>The research team, led by Dr. HU Li from the Institute of Psychology of the Chinese Academy of Sciences and Dr. CHEN Zhoufeng from Washington University School of Medicine and the Shenzhen Medical Academy of Research and Translation, used advanced techniques including transgenic mice, chemogenetics, optogenetics, and fiber photometry to uncover the biological mechanisms driving this behavior.<\/p>\n<p>Their findings identify oxytocin\u2014often called the &#8220;prosocial hormone&#8221; in humans\u2014as the key molecular player coordinating the helping response through two distinct brain pathways.<\/p>\n<p>When an observer mouse encounters an anesthetized companion, oxytocin neurons in the paraventricular nucleus of the hypothalamus activate. The released oxytocin then works through parallel pathways to coordinate both the emotional and physical aspects of the helping behavior.<\/p>\n<p>One pathway, through the central amygdala, processes the emotional component\u2014recognizing the distress of the unconscious mouse. Meanwhile, a second pathway through the dorsal bed n<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Scientists have discovered that mice naturally help their unconscious companions without any training or rewards, challenging long-held assumptions about animal altruism and revealing surprising parallels between rodent and human social behavior. When placed near an anesthetized mouse, observer mice show clear signs of distress and quickly begin grooming and licking their unconscious companions. This behavior &#8230; <a title=\"Mice Show Empathy, Help Unconscious Friends\" class=\"read-more\" href=\"https:\/\/scienceblog.com\/sciencechina\/2025\/04\/24\/mice-show-empathy-help-unconscious-friends\/\" aria-label=\"Read more about Mice Show Empathy, Help Unconscious Friends\">Read more<\/a><\/p>\n","protected":false},"author":1299,"featured_media":69,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[8,7],"tags":[],"class_list":["post-67","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-brain-behavior","category-life-nonhumans","generate-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-50"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.3 (Yoast SEO v27.3) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Mice Show Empathy, Help Unconscious Friends - SciChi<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/scienceblog.com\/sciencechina\/2025\/04\/24\/mice-show-empathy-help-unconscious-friends\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Mice Show Empathy, Help Unconscious Friends\" \/>\n<meta property=\"og:description\" content=\"Scientists have discovered that mice naturally help their unconscious companions without any training or rewards, challenging long-held assumptions about animal altruism and revealing surprising parallels between rodent and human social behavior. When placed near an anesthetized mouse, observer mice show clear signs of distress and quickly begin grooming and licking their unconscious companions. This behavior ... 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Inside a research lab in China, nine aged rhesus monkeys sat near speakers emitting 40-hertz tones for an\u2026","rel":"","context":"In &quot;Brain &amp; Behavior&quot;","block_context":{"text":"Brain &amp; Behavior","link":"https:\/\/scienceblog.com\/sciencechina\/category\/brain-behavior\/"},"img":{"alt_text":"monkey looking thoughtful","src":"https:\/\/i0.wp.com\/scienceblog.com\/sciencechina\/wp-content\/uploads\/sites\/16\/2026\/01\/pexels-alexasfotos-11171325.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/scienceblog.com\/sciencechina\/wp-content\/uploads\/sites\/16\/2026\/01\/pexels-alexasfotos-11171325.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/scienceblog.com\/sciencechina\/wp-content\/uploads\/sites\/16\/2026\/01\/pexels-alexasfotos-11171325.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/scienceblog.com\/sciencechina\/wp-content\/uploads\/sites\/16\/2026\/01\/pexels-alexasfotos-11171325.jpg?resize=700%2C400&ssl=1 2x"},"classes":[]},{"id":346,"url":"https:\/\/scienceblog.com\/sciencechina\/2026\/01\/28\/new-technique-unlocks-gene-therapy-for-hundreds-of-conditions\/","url_meta":{"origin":67,"position":3},"title":"New Technique Unlocks Gene Therapy for Hundreds of Conditions","author":"ScienceBlog.com","date":"January 28, 2026","format":false,"excerpt":"Gene therapy just leapt past a barrier that's held it back for years. Researchers in China have worked out how to pack oversized genes into the viral delivery vehicles that doctors use to treat genetic diseases, a trick that could unlock treatments for hundreds of conditions previously considered untreatable. The\u2026","rel":"","context":"In &quot;Health&quot;","block_context":{"text":"Health","link":"https:\/\/scienceblog.com\/sciencechina\/category\/health\/"},"img":{"alt_text":"Graphical abstract","src":"https:\/\/i0.wp.com\/scienceblog.com\/sciencechina\/wp-content\/uploads\/sites\/16\/2026\/01\/fx1_lrg.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/scienceblog.com\/sciencechina\/wp-content\/uploads\/sites\/16\/2026\/01\/fx1_lrg.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/scienceblog.com\/sciencechina\/wp-content\/uploads\/sites\/16\/2026\/01\/fx1_lrg.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/scienceblog.com\/sciencechina\/wp-content\/uploads\/sites\/16\/2026\/01\/fx1_lrg.jpg?resize=700%2C400&ssl=1 2x"},"classes":[]},{"id":219,"url":"https:\/\/scienceblog.com\/sciencechina\/2025\/07\/25\/ancient-desert-berry-shows-rare-power-to-reverse-diabetes-in-mice\/","url_meta":{"origin":67,"position":4},"title":"Ancient Desert Berry Shows Rare Power to Reverse Diabetes in Mice","author":"SciChi","date":"July 25, 2025","format":false,"excerpt":"A crimson berry long prized by nomads in western China is offering new hope in the fight against type 2 diabetes. Scientists have shown that a natural extract from the fruit of Nitraria roborowskii Kom\u2014known locally as the \u201cdesert cherry\u201d\u2014can dramatically reduce blood sugar, restore insulin sensitivity, and protect organs\u2026","rel":"","context":"In &quot;Health&quot;","block_context":{"text":"Health","link":"https:\/\/scienceblog.com\/sciencechina\/category\/health\/"},"img":{"alt_text":"Nitraria roborowskii Kom","src":"https:\/\/i0.wp.com\/scienceblog.com\/sciencechina\/wp-content\/uploads\/sites\/16\/2025\/07\/nitraria-37e12c3a-fcd6-4e31-ac60-1df56ac2965-resize-750.jpeg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/scienceblog.com\/sciencechina\/wp-content\/uploads\/sites\/16\/2025\/07\/nitraria-37e12c3a-fcd6-4e31-ac60-1df56ac2965-resize-750.jpeg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/scienceblog.com\/sciencechina\/wp-content\/uploads\/sites\/16\/2025\/07\/nitraria-37e12c3a-fcd6-4e31-ac60-1df56ac2965-resize-750.jpeg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/scienceblog.com\/sciencechina\/wp-content\/uploads\/sites\/16\/2025\/07\/nitraria-37e12c3a-fcd6-4e31-ac60-1df56ac2965-resize-750.jpeg?resize=700%2C400&ssl=1 2x"},"classes":[]},{"id":395,"url":"https:\/\/scienceblog.com\/sciencechina\/2026\/03\/13\/yak-gene-could-repair-damaged-nerves-in-multiple-sclerosis\/","url_meta":{"origin":67,"position":5},"title":"Yak Gene Could Repair Damaged Nerves in Multiple Sclerosis","author":"SciChi","date":"March 13, 2026","format":false,"excerpt":"Every nerve fibre in your brain and spinal cord is wrapped in something a bit like electrical tape. The myelin sheath, as it's called, is a fatty insulating layer produced by specialist cells called oligodendrocytes, and without it, nerve signals lose their speed and coherence. In multiple sclerosis, the immune\u2026","rel":"","context":"Similar post","block_context":{"text":"Similar post","link":""},"img":{"alt_text":"Yak","src":"https:\/\/i0.wp.com\/scienceblog.com\/sciencechina\/wp-content\/uploads\/sites\/16\/2026\/03\/pexels-soulofmurcidus-8843014.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/scienceblog.com\/sciencechina\/wp-content\/uploads\/sites\/16\/2026\/03\/pexels-soulofmurcidus-8843014.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/scienceblog.com\/sciencechina\/wp-content\/uploads\/sites\/16\/2026\/03\/pexels-soulofmurcidus-8843014.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/scienceblog.com\/sciencechina\/wp-content\/uploads\/sites\/16\/2026\/03\/pexels-soulofmurcidus-8843014.jpg?resize=700%2C400&ssl=1 2x"},"classes":[]}],"_links":{"self":[{"href":"https:\/\/scienceblog.com\/sciencechina\/wp-json\/wp\/v2\/posts\/67","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/scienceblog.com\/sciencechina\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/scienceblog.com\/sciencechina\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/scienceblog.com\/sciencechina\/wp-json\/wp\/v2\/users\/1299"}],"replies":[{"embeddable":true,"href":"https:\/\/scienceblog.com\/sciencechina\/wp-json\/wp\/v2\/comments?post=67"}],"version-history":[{"count":1,"href":"https:\/\/scienceblog.com\/sciencechina\/wp-json\/wp\/v2\/posts\/67\/revisions"}],"predecessor-version":[{"id":68,"href":"https:\/\/scienceblog.com\/sciencechina\/wp-json\/wp\/v2\/posts\/67\/revisions\/68"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/scienceblog.com\/sciencechina\/wp-json\/wp\/v2\/media\/69"}],"wp:attachment":[{"href":"https:\/\/scienceblog.com\/sciencechina\/wp-json\/wp\/v2\/media?parent=67"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/scienceblog.com\/sciencechina\/wp-json\/wp\/v2\/categories?post=67"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/scienceblog.com\/sciencechina\/wp-json\/wp\/v2\/tags?post=67"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}