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New mouse model could revolutionize Alzheimer’s research

Alzheimer's disease, the primary cause of dementia in the elderly, imposes a tremendous social and economic burden on modern society. In Japan, the burden...

Study shows where Alzheimer’s starts and how it spreads

Using high-resolution functional MRI (fMRI) imaging in patients with Alzheimer's disease and in mouse models of the disease, Columbia University Medical Center (CUMC) researchers...
Alzheimer's disease could be transmissable like prion illness

New drugs to find the right target to fight Alzheimer’s disease

The future is looking good for drugs designed to combat Alzheimer's disease. EPFL scientists have unveiled how two classes of drug compounds currently in clinical...

Unlocking the secret(ase) of building neural circuits

LA JOLLA, CA -- Mutant presenilin is infamous for its role in the most aggressive form of Alzheimer's disease -- early-onset familial Alzheimer's -- which can strike people as early as their 30s. In their latest study, researchers at the Sal...

Function found for Alzheimer’s protein

In people with Alzheimer's, the brain becomes riddled with clumps of protein, forming what are known as amyloid plaques. Now, a report appearing in the September 17th print issue of Cell appears to have found a function for the amyloid precursor pro...

Alzheimer's protein jams mitochondria; resulting 'energy crisis' kills neurons

Opening a new front in the battle against Alzheimer's disease, scientists at the University of Pennsylvania have found that a protein long associated with the disease inflicts grave damage in a previously unimagined way: It seals off mitochondria in affected neurons, resulting in an "energy crisis" and buildup of toxins that causes cells to die. This pathway, the first specific biochemical explanation for pathologies associated with Alzheimer's, is detailed in the April 14 issue of the Journal of Cell Biology.

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