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A key step in understanding the origins of familial breast cancer has been made by two teams of scientists at the University of California, Davis. The researchers have purified, for the first time, the protein produced by the breast cancer suscep...
BRCA-2, a gene linked with breast and ovarian cancer, cooperates with male sex hormones to enhance its ability to activate transcription of genes, which may suppress tumor formation in normal cells, Salk Institute researchers have found. The study, published in the June 10 Proceedings of the National Academy of Sciences, provides details on how the normal form of the gene may work, and how mutant forms of BRCA-2 may malfunction and therefore likely contribute to the development of breast cancer. It also gives greater insight into the causes of male breast cancer. BRCA-2 is one of two genes (the other is BRCA-1) linked to at least 10 percent of all breast cancers; the mutant form appears in nearly all male breast cancers.
Scientists at Tularik Inc. and Cold Spring Harbor Laboratory have discovered a new gene that is expressed at abnormally high levels in nearly 50% of the breast cancer specimens they examined, and is similarly overexpressed in a large proportion of lung cancers (35%).